A new method for evaluating the dissolution of orodispersible films.

abstract：:Multivesicular liposomes (MVLs) have been widely studied for encapsulation of hydrophilic drugs due to their structural properties and large aqueous inner cavities. In this study, to investigate MVLs and their potential application for incorporation of hydrophobic drugs, new drug delivery system for fluocinolone aceto...

journal_title：Pharmaceutical development and technology

authors： Vafaei SY,Dinarvand R,Esmaeili M,Mahjub R,Toliyat T

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To investigate the influence of the pH of the dissolution medium on immediate release 850 mg metformin hydrochloride tablets. METHODS:A traditional wet granulation method was used to manufacture metformin hydrochloride tablets with or without a disintegrant. Tablet dissolution was conducted using the USP appar...

journal_title：Pharmaceutical development and technology

authors： Desai D,Wong B,Huang Y,Tang D,Hemenway J,Paruchuri S,Guo H,Hsieh D,Timmins P

更新日期：2015-01-01 00:00:00

abstract：:Understanding variability in excipient physico-chemical properties is becoming an important aspect of Quality-by-Design drug product development. However, present experimental methods have only been able to study a few physico-chemical properties for a few excipient lots due to time, cost, and sample gathering conside...

journal_title：Pharmaceutical development and technology

authors： Kushner J 4th

更新日期：2013-03-01 00:00:00

abstract：:In this study, the degradation of Octastatin, a cyclic octapeptide analog of somatostatin, was examined as a function of pH, temperature, buffer, and ionic strength by reversed-phase gradient high-performance liquid chromatography. Degradation of Octastatin followed a first-order kinetics. Various buffer species such ...

journal_title：Pharmaceutical development and technology

authors： Jang SW,Woo BH,Lee JT,Moon SC,Lee KC,DeLuca PP

更新日期：1997-11-01 00:00:00

abstract：:The contact time of a vehicle on the cornea is of utmost importance for ophthalmic drug delivery. The poor bioavailability and therefore poor therapeutic response exhibited by the conventional ophthalmic solutions due to pre-corneal elimination of a drug may be overcome by the use of the in situ gel forming systems, w...

journal_title：Pharmaceutical development and technology

authors： Gupta S,Samanta MK

更新日期：2010-07-01 00:00:00

abstract：:This paper assesses the cause of particulate formation in vials of the experimental antitumor agent bisnafide and investigates pharmaceutical techniques to reduce the number of particulates in the product. Solution preparation and particulate isolation were performed under Class 100 laminar air flow. Reversed-phase HP...

journal_title：Pharmaceutical development and technology

authors： Rubino JT,Chan LL,Walker JT,Segretario J,Everlof JG,Hussain MA

更新日期：1999-08-01 00:00:00

abstract：:Orally dissolving tablets (ODTs) represent one of the recent advances in drug delivery. The foremost objective of this study was to optimize the utilization of lubricant sodium stearyl fumarate in the preparation of dextromethorphan hydrobromide ODTs with enhanced taste-masking properties. The simple blending of sodiu...

journal_title：Pharmaceutical development and technology

authors： Mahrous GM,Ibrahim MA,Mostafa HF,Elzayat EM

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:Aerodynamically stable, nebulized aerosols are desirable to achieve optimum asthma therapy. Stabilizing droplet size using gel-forming polymers may assist in achieving this goal. Semisolid particles may be generated through aerosolization of a polymer solution. Gelatin was employed as a model polymer in a proce...

journal_title：Pharmaceutical development and technology

authors： Deaton AT,Jones LD,Dunbar CA,Hickey AJ,Williams DM

更新日期：2002-05-01 00:00:00

abstract：:Objective: A polymer-based nanoparticle was constructed to target sorafenib delivery to colorectal carcinoma cells and decrease the side effects of the drug.Methods: Sorafenib-loaded nanoparticles (S-NPs) based on PEG-PLGA were prepared using a double emulsion solvent evaporation method. The properties of S-NPs were e...

journal_title：Pharmaceutical development and technology

authors： Li N,Chen Y,Sun H,Huang T,Chen T,Jiang Y,Yang Q,Yan X,Wu M

更新日期：2020-06-01 00:00:00

abstract：:Tablet hardness, a measure of the breaking force of a tablet, is based on numerous factors. These include the shape of the tablet and the mode of the application of force. For instance, when a pentagonal-shaped tablet was tested with a traditional hardness tester with flat platens, there was a large variation in hardn...

journal_title：Pharmaceutical development and technology

authors： Malladi J,Sidik K,Wu S,McCann R,Dougherty J,Parab P,Carragher T

更新日期：2017-03-01 00:00:00

abstract：:Clinical trials of cholesterol ester transfer protein (CETP) peptide vaccine were stopped after disappointing results in humans due to the inadequacy of adjuvant aluminum hydroxide in stimulating the immune response against the self-antigen of CETP. To increase the efficacy of the CETP vaccine, we developed a novel li...

journal_title：Pharmaceutical development and technology

authors： Aghebati T,Arabsalmani M,Mohammadpour AH,Afshar M,Jaafari MR,Abnous K,Nazemi S,Badiee A

更新日期：2020-04-01 00:00:00

abstract：:A novel flavonoid-polysaccharide conjugate was synthesized by free radical grafting of quercetin on starch. The covalent insertion of quercetin in the polymeric chain was confirmed by FT-IR, DSC and fluorescence analyses, while an estimation of the amount of quercetin bound per g of polymer was obtained by the Folin-C...

journal_title：Pharmaceutical development and technology

authors： Cirillo G,Puoci F,Iemma F,Curcio M,Parisi OI,Spizzirri UG,Altimari I,Picci N

更新日期：2012-07-01 00:00:00

abstract：:In this study, chlorhexidine-loaded poly(ε-caprolactone) nanospheres (CHX-NS) were prepared and successfully coated on the urinary catheters. Properties of CHX-NS were evaluated including drug loading content and the nanosphere size. Effects of different lyoprotectants for long-term storage of CHX-NS were also investi...

journal_title：Pharmaceutical development and technology

authors： Srisang S,Nasongkla N

更新日期：2019-04-01 00:00:00

abstract：:Mefenamic acid (MA), a poorly water-soluble drug, was used as a model substance to investigate granules and tablet characteristics to be optimized for the loading volume of MA (0-74.1% v/v) in the formulation including lactose monohydrate/maize starch (7/3) as excipients. The compactibility of granules increased with ...

journal_title：Pharmaceutical development and technology

authors： Kimura G,Betz G,Leuenberger H

更新日期：2008-01-01 00:00:00

abstract：:The present study was aimed to develop a matrix-type transdermal formulation of pentazocine using mixed polymeric grades of Eudragit RL/RS. The possible interaction between drug and polymer used were characterized by FTIR, DSC and X-RD. X-RD study indicates a change of state of drug from crystalline to amorphous in th...

journal_title：Pharmaceutical development and technology

authors： Chandak AR,Prasad Verma PR

更新日期：2010-06-01 00:00:00

abstract：:The objective of this investigation was to formulate ocular inserts of gatifloxacin sesquehydrate to achieve controlled drug release. Drug reservoir was prepared using hydrophilic polymers, namely polyvinyl alcohol and polyvinyl pyrrolidone. The rate controlling membrane was prepared using hydrophobic ethyl cellulose ...

journal_title：Pharmaceutical development and technology

authors： Patel UL,Chotai NP,Nagda CD

更新日期：2012-01-01 00:00:00

abstract：:The main purpose of this work was to develop a supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) of carbamazepine (CBZ). S-SMEDDS of CBZ was prepared and drug precipitation behavior, dissolution rate in vitro and particle size distribution were evaluated. The relative bioavailability of S-SMEDDS f...

journal_title：Pharmaceutical development and technology

authors： Zhang N,Zhang W,Jin Y,Quan DQ

更新日期：2011-08-01 00:00:00

abstract：:A paddle method for measurement of the disintegrating time of orally disintegrating tablets with rizatriptan benzoate as a model drug was evaluated. The paddle method employed a dissolution test assembly with tablets immersed in disintegrating medium through a fastened sinker. Paddle stirring rate, opening of the sink...

journal_title：Pharmaceutical development and technology

authors： Que L,Wu W,Cheng X,Hu T

更新日期：2006-01-01 00:00:00

abstract：:A redox-responsive docetaxel (DTX) prodrug consisting of a disulfide linkage between DTX and vitamin E (DTX-SS-VE) was synthesized in our laboratory and was successfully formulated into liposomes. The aim of this study was to optimize the formulation and investigate the cellular uptake of DTX prodrug-loaded liposomes ...

journal_title：Pharmaceutical development and technology

authors： Ren G,Jiang M,Guo W,Sun B,Lian H,Wang Y,He Z

更新日期：2018-01-01 00:00:00

abstract：:Poor solubility and bioavailability of drugs are often affected by its microscopic structural properties. Nitrofurantoin (NF), a Biopharmaceutics Classification System class II item, has a low water solubility with low plasma concentrations. To improve its therapeutic efficacy, formulation strategy of solid dispersion...

journal_title：Pharmaceutical development and technology

authors： Teoh XY,Bt Mahyuddin FN,Ahmad W,Chan SY

更新日期：2020-02-01 00:00:00

abstract：CONTEXT:Bioadhesiviness of polyacrylic acid polymers make them promising hydrogels to design topical drug delivery systems, allowing a close contact with biological substrate as well as an enhanced local concentration gradient, both factors that may improve the biological performance of the drugs. AIM:Texture and bioa...

journal_title：Pharmaceutical development and technology

authors： Calixto G,Yoshii AC,Rocha e Silva H,Stringhetti Ferreira Cury B,Chorilli M

更新日期：2015-06-01 00:00:00

abstract：:Owing to its limited aqueous solubility, Phytomenadione (vitamin K) undergoes a low bioavailability (50%) with a large inter-individual variability after oral administration. Therefore, the aim of this work was to incorporate vitamin K into nanostructure lipid carrier systems to improve its aqueous solubility and bioa...

journal_title：Pharmaceutical development and technology

authors： Aljaeid BM,Hosny KM

更新日期：2018-04-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cause of cancer-related death in both men and women. Often, surgical intervention remains the choice in treating CRC. Traditional dosage forms used for treating CRC deliver drug to wanted as well as unwanted sites of drug action resulting in several adverse side effects...

journal_title：Pharmaceutical development and technology

authors： Krishnaiah YS,Khan MA

更新日期：2012-09-01 00:00:00

abstract：:The aim of this study was to investigate early formulation screening in small scale with a miniaturized fluid bed device. Altogether eight different batches were granulated in a Multipart Microscale Fluid bed Powder processor (MMFP) with constant process conditions using electrostatic atomization. Atomization voltage ...

journal_title：Pharmaceutical development and technology

authors： Kivikero N,Murtomaa M,Antikainen O,Hatara J,Juppo AM,Sandler N

更新日期：2011-08-01 00:00:00

abstract：:Novel buccal adhesive system (NBAS) containing Nimodipine (N) was prepared and evaluated by different parameters such as weight uniformity, thickness, hardness, surface pH, swelling index, mucoadhesive strength (MS), in vitro drug release and ex vivo drug permeation. Different formulations containing 5-20% Carbopol 93...

journal_title：Pharmaceutical development and technology

authors： Hassan N,Ali M,Ali J

更新日期：2010-03-01 00:00:00

abstract：:The interaction of 5-nitro-2-furfurilylidene benzhydrazide (5NFB), potential anti-trypanosomal compound, with micellar solutions was studied. The results indicated that 50 mug of 5NFB completely kills 20 million T. cruzi epimastigote cells within 3 days, whereas the same amount of benznidazole kills 30% of the cells a...

journal_title：Pharmaceutical development and technology

authors： Rangel-Yagui CO,Hsu HW,Barbosa LR,Caetano W,Pessoa A Jr,Tavares LC,Itri R

更新日期：2007-01-01 00:00:00

abstract：:The objective of this paper was to evaluate the mucoadhesive and sustained-release properties of the water-soluble gum obtained from Hakea gibbosa (hakea), for the formulation of buccal tablets. Flatfaced tablets containing hakea were formulated using chlorpheniramine maleate (CPM) as a model drug. Two types of tablet...

journal_title：Pharmaceutical development and technology

authors： Alur HH,Pather SI,Mitra AK,Johnston TP

更新日期：1999-08-01 00:00:00

abstract：:Drug release from hydroxypropyl methylcellulose (HPMC) hydrophilic matrix tablets is controlled by drug diffusion through the gel layer of the matrix-forming polymer upon hydration, matrix erosion or combination of diffusion and erosion mechanisms. In this study, the relationship between viscoelastic properties of the...

journal_title：Pharmaceutical development and technology

authors： Hamed R,Al Baraghthi T,Sunoqrot S

更新日期：2018-11-01 00:00:00

abstract：:The general solubility equation (GSE) is the state-of-the-art method for estimating the aqueous solubilities of organic compounds. It is an extremely simple equation that expresses aqueous solubility as a function of only two inputs: the octanol-water partition coefficient calculated by readily available softwares lik...

journal_title：Pharmaceutical development and technology

authors： Alantary D,Yalkowsky S

更新日期：2018-09-01 00:00:00

abstract：:The purpose of this work was to prepare and characterize Angiopep-2 functionalized ginsenoside-Rg3 loaded nanoparticles (ANG-Rg3-NP) and evaluate the therapeutic effect on C6 glioma cells. Nanoparticles were prepared by the emulsion solvent evaporation method. Angiopep-2 was functionalized to nanoparticles via a malei...

journal_title：Pharmaceutical development and technology

authors： Su X,Zhang D,Zhang H,Zhao K,Hou W

更新日期：2020-03-01 00:00:00