Design and evaluation of thermoreversible in situ gelling system of forskolin for the treatment of glaucoma.

abstract：:Alpha lipoic acid (ALA), an active substance in anti-aging products and dietary supplements, need to be masked with an edible polymer to obscure its unpleasant taste. However, the high viscosity of the ALA molecules prevents them from forming microcomposites with masking materials even in supercritical carbon dioxide ...

journal_title：Pharmaceutical development and technology

authors： Mishima K,Honjo M,Sharmin T,Ito S,Kawakami R,Kato T,Misumi M,Suetsugu T,Orii H,Kawano H,Irie K,Sano K,Mishima K,Harada T,Ouchi M

更新日期：2016-09-01 00:00:00

abstract：:In recent years, drug delivery systems such as liposomes and microparticles have been used in clinic for the treatment of different diseases and from a regulatory point of view, a parenterally applied drug and drug delivery systems must be sterile and pyrogen free. Radiation sterilization is a method recognized by pha...

journal_title：Pharmaceutical development and technology

authors： Sakar F,Özer AY,Erdogan S,Ekizoglu M,Kart D,Özalp M,Colak S,Zencir Y

更新日期：2017-09-01 00:00:00

abstract：:The present work investigated the magnitude of microsphere-induced acute myotoxicity and determined whether this myotoxicity is related to microsphere size and/or reconstitution solvent. Using a high molecular weight poly(dl-lactide-co-glycolide) copolymer, the myotoxicity of two different size microsphere formulation...

journal_title：Pharmaceutical development and technology

authors： Brazeau GA,Sciame M,al-Suwayeh SA,Fattal E

更新日期：1996-10-01 00:00:00

abstract：:Magnesium stearate (MgSt) is a widely used pharmaceutical lubricant in tablet manufacturing. However, batch-to-batch variability in hydrate form and surface area can lead to inconsistency in tablet performance. In this work, several unique MgSt samples were studied: traditional monohydrate samples with high surface ar...

journal_title：Pharmaceutical development and technology

authors： Calahan JL,Paul S,Yanez EG,DeNeve D,Sun CC,Munson EJ

更新日期：2021-02-01 00:00:00

abstract：:The purpose of this research was to prepare various injectable, protein (cytochrome c)-loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices by a novel microencapsulation method and to compare their characteristics. Syringeable mixtures of polymer and protein solidified upon injection when coming in contact w...

journal_title：Pharmaceutical development and technology

authors： Jain RA,Rhodes CT,Railkar AM,Malick AW,Shah NH

更新日期：2000-01-01 00:00:00

abstract：INTRODUCTION:Theoretical models of the freeze-drying process are potentially useful to guide the design of a freeze-drying process as well as to obtain information not readily accessible by direct experimentation, such as moisture distribution and glass transition temperature, Tg, within a vial during processing. Previ...

journal_title：Pharmaceutical development and technology

authors： Pikal MJ,Cardon S,Bhugra C,Jameel F,Rambhatla S,Mascarenhas WJ,Akay HU

更新日期：2005-01-01 00:00:00

abstract：:It is well known that carriers can affect the dissolution of poorly soluble drugs. In this study, our aim was to investigate the dissolution enhancement of carbamazepine solid dispersed or mixed at different loading ratios in crospovidone, polyvinylpyrrolidone, and sodium starch glycolate. The physical state of the dr...

journal_title：Pharmaceutical development and technology

authors： Moneghini M,Voinovich D,Perissutti B,Princivalle F

更新日期：2002-01-01 00:00:00

abstract：:Controlled release of a marker drug, 4,4'-bis(2-sulfostyryl) biphenyl (DSBP) from genipin crosslinked gelatin thin films, with application to drug delivery by transdermal patches is studied in this paper. A simple method for fabrication of nano-thin films, using basic lab equipment is introduced. This method consists ...

journal_title：Pharmaceutical development and technology

authors： Abbasi A,Eslamian M,Heyd D,Rousseau D

更新日期：2008-01-01 00:00:00

abstract：:ABSTRCT Felodipine has been widely used as a poorly water-soluble model drug for various studies to improve its oral bioavailability and in vivo efficacy. In this study, we developed amorphous solid dispersions (ASDs) via spray drying to enhance the bioavailability of felodipine through using natural zein protein as a...

journal_title：Pharmaceutical development and technology

authors： Zhang H,Liu X,Ma X

更新日期：2020-12-01 00:00:00

abstract：:Dissolution profiles of various multiparticulate controlled-release dosage forms prepared by applying lipophilic materials using a hot-melt coating technique were analyzed to determine release kinetics. The dosage forms were prepared using a novel solid dispersion hot-melt fluid bed coating method. Various lipophilic ...

journal_title：Pharmaceutical development and technology

authors： Griffin EN,Niebergall PJ

更新日期：1999-01-01 00:00:00

abstract：:The binding mechanism of tablets prepared by single-step granulation/tabletting (SSGT), a novel technique for the production of tablets, was evaluated. SSGT yielded hard tablets having a short disintegration time due to their porous, spongelike internal structure. Calculation of the interaction factor and electrical c...

journal_title：Pharmaceutical development and technology

authors： Vermeire A,Keleb EI,Kiekens F,Van Driessche I,Hoste S,Remon JP,Vervaet C

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To investigate the influence of the pH of the dissolution medium on immediate release 850 mg metformin hydrochloride tablets. METHODS:A traditional wet granulation method was used to manufacture metformin hydrochloride tablets with or without a disintegrant. Tablet dissolution was conducted using the USP appar...

journal_title：Pharmaceutical development and technology

authors： Desai D,Wong B,Huang Y,Tang D,Hemenway J,Paruchuri S,Guo H,Hsieh D,Timmins P

更新日期：2015-01-01 00:00:00

abstract：:Oily liquid drugs are not convenient for oral administration. We developed a powder containing clofibrate (CF), a model of an oily drug, using aminoalkyl methacrylate copolymer (EPO) or methacrylic acid copolymer (L100). CF or a mixture of CF and soybean oil was emulsified with EPO or L100 aqueous solution. Using a hi...

journal_title：Pharmaceutical development and technology

authors： Fujii M,Kawakami A,Saito A,Tuchiya H,Koizumi N,Watanabe Y

更新日期：2016-12-01 00:00:00

abstract：:Two polymorphs and three solvates of fluconazole were isolated and characterized by x-ray powder diffractometry, IR spectroscopy, differential scanning calorimetry (DSC), thermogravimetry, and their dissolution rates. The different forms were prepared by crystallization of the original powder in different solvents at ...

journal_title：Pharmaceutical development and technology

authors： Alkhamis KA,Obaidat AA,Nuseirat AF

更新日期：2002-11-01 00:00:00

abstract：:The hygroscopicity of Brequinar sodium, an organ transplant immunosuppressant, at 75% relative humidity highly depends on the crystal form or crystallinity of the drug substance. Hygroscopicity and ease of water uptake of three lots of Brequinar sodium were investigated. Those lots contained different impurities at le...

journal_title：Pharmaceutical development and technology

authors： Wu LS,Pang J,Hussain MA

更新日期：1996-04-01 00:00:00

abstract：:The high initial burst release of a highly water-soluble drug from poly (D,L-lactide-co-glycolide) (PLGA) microparticles prepared by the multiple emulsion (w/o/w) solvent extraction/evaporation method was reduced by coating with an additional polymeric PLGA layer. Coating with high encapsulation efficiency was perform...

journal_title：Pharmaceutical development and technology

authors： Ahmed AR,Elkharraz K,Irfan M,Bodmeier R

更新日期：2012-01-01 00:00:00

abstract：:The first-line therapy for moderate to severe benign prostatic hyperplasia is the oral therapy by alfuzosin hydrochloride. Unfortunately, the oral therapy of alfuzosin is associated with several route-specific systemic side-effects. The current study was aimed to develop a prototype transdermal patch system for alfuzo...

journal_title：Pharmaceutical development and technology

authors： Nair AB,Vaka SR,Gupta S,Repka MA,Murthy SN

更新日期：2012-03-01 00:00:00

abstract：:The objective of this study was to compare the dissolution behavior of tablets prepared from solid dispersions with and without drug-carrier interactions. Diazepam and nifedipine were used as model drugs. Two types of carriers were used; polyvinylpyrrolidone (PVP K12, K30 and K60) and saccharides (inulin 1.8 kDa, 4 kD...

journal_title：Pharmaceutical development and technology

authors： Srinarong P,Kouwen S,Visser MR,Hinrichs WL,Frijlink HW

更新日期：2010-09-01 00:00:00

abstract：:The aim of this study was to develop and characterize nanocrystal formulation containing nimesulide. Physical mixture of drug and excipient (nimesulide:pluronic F127, 1:0.5) was also prepared to compare the efficiency of formulations. The physicochemical characteristics of the formulations were determined by means of ...

journal_title：Pharmaceutical development and technology

authors： Gülsün T,Budak C,Vural I,Sahin S,Öner L

更新日期：2013-05-01 00:00:00

abstract：:In the present study, Simvastatin was incorporated in emulsion of soybean oil and propylene glycol monocaprylate as oily phase and Tween 80 and Cremophor EL as surfactants and also their mixtures. Dry adsorbed emulsions were prepared by using colloidal silicon dioxide in varying proportions to adsorb the liquid emulsi...

journal_title：Pharmaceutical development and technology

authors： Dixit RP,Nagarsenker MS

更新日期：2007-01-01 00:00:00

abstract：:Co-solvent solubilization approach has been used to enhance the solubility of seven antidiabetic drugs: gliclazide, glyburide, glipizide, glimepiride, repaglinide, pioglitazone, and roziglitazone. Solubility in water, phosphate buffer (pH 7.4), six co-solvent solutions prepared in water as well as phosphate buffer (pH...

journal_title：Pharmaceutical development and technology

authors： Seedher N,Kanojia M

更新日期：2009-01-01 00:00:00

abstract：:The oral administration route is considered to be the most widely used route because of its convenience of administration and manufacturing. Dosage forms, like orally disintegrating tablets (ODTs), mini tablets, and orally disintegrating mini tablets (ODMTs), are recognized as promising for use in pediatric patients. ...

journal_title：Pharmaceutical development and technology

authors： Comoglu T,Dilek Ozyilmaz E

更新日期：2019-09-01 00:00:00

abstract：:This paper explores the utility of aqueous solubility of structurally similar drugs in predicting optimum conditions for extrusion and spheronization of pellets using response surface methodology. Pharmacologically active xanthine derivatives exhibiting widely varying aqueous solubility were used to determine optimum ...

journal_title：Pharmaceutical development and technology

authors： Hileman GA,Upadrashta SM,Neau SH

更新日期：1997-02-01 00:00:00

abstract：:The aim of this study was to investigate intravitreal injection of silk fibroin nanoparticles (SFNs) encapsulating bio-macromolecules, achieving enhanced drug bioavailability, and extended retention in retina. SFNs were prepared with regenerated silk fibroin using desolvation method with fluorescein isothiocyanate lab...

journal_title：Pharmaceutical development and technology

authors： Yang P,Dong Y,Huang D,Zhu C,Liu H,Pan X,Wu C

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:The purpose of the present investigation was to prepare a plasma stable, pH-sensitive niosomal formulation to enhance Sirolimus efficacy and selectivity. MATERIALS AND METHODS:pH-sensitive niosomal formulations bearing PEG-Poly (monomethyl itaconate)-CholC6 (PEG-PMMI-CholC6) copolymers and cholesteryl hemisu...

journal_title：Pharmaceutical development and technology

authors： Ghanbarzadeh S,Khorrami A,Pourmoazzen Z,Arami S

更新日期：2015-05-01 00:00:00

abstract：:Orally dissolving tablets (ODTs) represent one of the recent advances in drug delivery. The foremost objective of this study was to optimize the utilization of lubricant sodium stearyl fumarate in the preparation of dextromethorphan hydrobromide ODTs with enhanced taste-masking properties. The simple blending of sodiu...

journal_title：Pharmaceutical development and technology

authors： Mahrous GM,Ibrahim MA,Mostafa HF,Elzayat EM

更新日期：2019-07-01 00:00:00

abstract：:The objective of this investigation was to formulate ocular inserts of gatifloxacin sesquehydrate to achieve controlled drug release. Drug reservoir was prepared using hydrophilic polymers, namely polyvinyl alcohol and polyvinyl pyrrolidone. The rate controlling membrane was prepared using hydrophobic ethyl cellulose ...

journal_title：Pharmaceutical development and technology

authors： Patel UL,Chotai NP,Nagda CD

更新日期：2012-01-01 00:00:00

abstract：:The present study was carried out in order to mask the bitter taste of the Etoricoxib by complexation with cation-exchange resin, Indion 204. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 mi...

journal_title：Pharmaceutical development and technology

authors： Patra S,Samantaray R,Pattnaik S,Barik BB

更新日期：2010-09-01 00:00:00

abstract：:A high-pressure homogenization method for the production of aqueous suspensions of poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) was investigated. Depending on the production conditions it was possible to produce micro--as well as nanoparticulate systems without the use of organic solvents. The influence of dif...

journal_title：Pharmaceutical development and technology

authors： Calvör A,Müller BW

更新日期：1998-08-01 00:00:00

abstract：:In this study, we developed a one-step method to prepare ibuprofen fast- and sustained-release complex preparation. It was based on a double jets electrospinning process. Ibuprofen, a poorly water-soluble drug, was electrospun into fibers with polyvinyl pyrrolidone and hydroxypropyl methyl cellulose by two jets, respe...

journal_title：Pharmaceutical development and technology

authors： Che X,Xue J,Zhang J,Yang X,Wang L

更新日期：2020-07-01 00:00:00