Abstract:
:Dissolution profiles of various multiparticulate controlled-release dosage forms prepared by applying lipophilic materials using a hot-melt coating technique were analyzed to determine release kinetics. The dosage forms were prepared using a novel solid dispersion hot-melt fluid bed coating method. Various lipophilic materials were investigated and those showing promise as potential controlled-release coating agents were analyzed further. Dissolution data were used as the primary basis of comparison. A dual equation combining first-order and square-root-of-time release kinetics was used to fit data. The statistical output from nonlinear regression software suggests that this equation describes the data better than the individual equations alone. Particular parameters used to compare the various models include R2, the model selection criteria, and the coefficient of determination. The high degree of fit offered by the dual equation implies that two distinct kinetic processes may be involved in the release of drug from the dosage forms. A possible release mechanism based on this information is offered. The dual equation was shown to be a superior model for the controlled-release system chosen for study. The equation also appears to be applicable to a variety of other controlled-release systems reported in the literature.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Griffin EN,Niebergall PJdoi
10.1080/10837459908984231subject
Has Abstractpub_date
1999-01-01 00:00:00pages
117-24issue
1eissn
1083-7450issn
1097-9867journal_volume
4pub_type
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journal_title:Pharmaceutical development and technology
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doi:10.3109/10837450.2010.522585
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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abstract::Pharmaceutical aerosols have the potential to prevent pulmonary infectious diseases. Liposomal amphotericin B (LAMB, Ambisome, Astellas Pharma US, Deerfield, IL, USA) is approved as an intravenous infusion for empiric treatment of presumed fungal infections in neutropenic, febrile patients, as well as patients infecte...
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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更新日期:2013-05-01 00:00:00
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