In vitro characterization of nebulizer delivery of liposomal amphotericin B aerosols.

Abstract:

:Pharmaceutical aerosols have the potential to prevent pulmonary infectious diseases. Liposomal amphotericin B (LAMB, Ambisome, Astellas Pharma US, Deerfield, IL, USA) is approved as an intravenous infusion for empiric treatment of presumed fungal infections in neutropenic, febrile patients, as well as patients infected with Aspergillus, Cryptococcus, and other fungal pathogens. In this study, four different nebulizers were tested for their ability to deliver LAMB in aerodynamic droplet-size ranges relevant to lung deposition by an inertial sampling technique Mass median aerodynamic diameter (MMAD) and fine particle fraction percent <3.3 μm (FPF(3.3)) and <5.8 μm (FPF(5.8)) were determined by cascade impaction during a 2 min sampling period for each of three trials of all nebulizers. The MMADs for all nebulizers ranged from 1.72 ± 0.11 μm to 2.89 ± 0.12 μm; FPF(3.3) and FPF(5.8) were approximately 80% and 90%, respectively. Although all nebulizers appear acceptable for delivery of LAMB, the Pari LC Star and the Aeroeclipse II were considered the best in terms of delivery of aerosol efficiently and the proportion suitable for lung deposition. Additional research on pulmonary delivery and clinical tolerability is warranted.

journal_name

Pharm Dev Technol

authors

Alexander BD,Winkler TP,Shi S,Dodds Ashley ES,Hickey AJ

doi

10.3109/10837450.2011.591803

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

577-82

issue

6

eissn

1083-7450

issn

1097-9867

journal_volume

16

pub_type

杂志文章
  • Gas-saturated solution process to obtain microcomposite particles of alpha lipoic acid/hydrogenated colza oil in supercritical carbon dioxide.

    abstract::Alpha lipoic acid (ALA), an active substance in anti-aging products and dietary supplements, need to be masked with an edible polymer to obscure its unpleasant taste. However, the high viscosity of the ALA molecules prevents them from forming microcomposites with masking materials even in supercritical carbon dioxide ...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837450.2015.1049707

    authors: Mishima K,Honjo M,Sharmin T,Ito S,Kawakami R,Kato T,Misumi M,Suetsugu T,Orii H,Kawano H,Irie K,Sano K,Mishima K,Harada T,Ouchi M

    更新日期:2016-09-01 00:00:00

  • Stability of dry coated solid dosage forms.

    abstract::The dry coating process was evaluated in terms of storage stability investigating drug release and agglomeration tendency of the different coated oral dosage forms; hydroxypropyl methylcellulose acetate succinate (HPMCAS) was used with triethylcitrate (TEC) as plasticizer and acetylated monoglyceride (Myvacet) as wett...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837450902882336

    authors: Kablitz CD,Urbanetz NA

    更新日期:2009-01-01 00:00:00

  • Effect of degree of methoxylation and particle size on compression properties and compactibility of pectin powders.

    abstract::This study examines the effect of the degree of methoxylation (DM) and particle size on compression properties and compactibility of pectin powders. A powder classification system based on sequential handling of compression parameters was applied. A single size fraction (90-125 μm) of pectin powders with DM values ran...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837450.2010.535831

    authors: Salbu L,Bauer-Brandl A,Alderborn G,Tho I

    更新日期:2012-05-01 00:00:00

  • Production of microparticles by high-pressure homogenization.

    abstract::A high-pressure homogenization method for the production of aqueous suspensions of poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) was investigated. Depending on the production conditions it was possible to produce micro--as well as nanoparticulate systems without the use of organic solvents. The influence of dif...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837459809009857

    authors: Calvör A,Müller BW

    更新日期:1998-08-01 00:00:00

  • In vitro permeation study of a mucoadhesive drug delivery system for controlled delivery of nonoxynol-9.

    abstract::A carbopol 934P-based drug delivery system (AmDDS) was developed to achieve the dual-controlled delivery of Nonoxynol-9 (N-9), a spermicidal agent, and EDTA, a potentiator of spermicidal activity. This gel-type system made intimate contact with vaginal mucosa and maintained an effective drug concentration within the v...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837459609029888

    authors: Lee CH,Chien YW

    更新日期:1996-07-01 00:00:00

  • Plasma stable, pH-sensitive non-ionic surfactant vesicles simultaneously enhance antiproliferative effect and selectivity of Sirolimus.

    abstract:OBJECTIVE:The purpose of the present investigation was to prepare a plasma stable, pH-sensitive niosomal formulation to enhance Sirolimus efficacy and selectivity. MATERIALS AND METHODS:pH-sensitive niosomal formulations bearing PEG-Poly (monomethyl itaconate)-CholC6 (PEG-PMMI-CholC6) copolymers and cholesteryl hemisu...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837450.2013.860553

    authors: Ghanbarzadeh S,Khorrami A,Pourmoazzen Z,Arami S

    更新日期:2015-05-01 00:00:00

  • Silk fibroin nanoparticles for enhanced bio-macromolecule delivery to the retina.

    abstract::The aim of this study was to investigate intravitreal injection of silk fibroin nanoparticles (SFNs) encapsulating bio-macromolecules, achieving enhanced drug bioavailability, and extended retention in retina. SFNs were prepared with regenerated silk fibroin using desolvation method with fluorescein isothiocyanate lab...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1080/10837450.2018.1545236

    authors: Yang P,Dong Y,Huang D,Zhu C,Liu H,Pan X,Wu C

    更新日期:2019-06-01 00:00:00

  • Iontophoretic enhancement of leuprolide acetate by fatty acids, limonene, and depilatory lotions through porcine epidermis.

    abstract::The effect of chemical enhancers (e.g., fatty acids, limonene, depilatory lotions) and iontophoresis was investigated on the in vitro permeability of leuprolide acetate through porcine epidermis. Franz diffusion cells and Scepter iontophoretic power source were used for the percutaneous absorption studies. Anodal iont...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1081/pdt-200032986

    authors: Rastogi SK,Singh J

    更新日期:2004-11-01 00:00:00

  • Characterization of acid modified Dioscorea starches as direct compression excipient.

    abstract::Starches obtained from four different Dioscorea species namely White (D. rotundata), Bitter (D. dumetorum), Chinese (D. oppositifolia) and Water yam (D. alata), were modified by acid hydrolysis and the physicochemical, material and tablet formation properties of the starches were investigated with the aim of determini...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1080/10837450802572367

    authors: Odeku OA,Picker-Freyer KM

    更新日期:2009-01-01 00:00:00

  • Preparation and optimization of glyceryl behenate-based highly porous pellets containing cilostazol.

    abstract::The aim of this study was to prepare a highly porous multiparticulate dosage form containing cilostazol for gastroretentive drug delivery. The floating pellets were prepared with glyceryl behenate as a matrix former and camphor as a sublimating agent by extrusion/spheronization and sublimation under vacuum. Granules p...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1080/10837450.2016.1245743

    authors: Hwang KM,Byun W,Cho CH,Park ES

    更新日期:2018-06-01 00:00:00

  • Pharmacokinetics of 16-dehydropregnenolone hydroxypropyl-β-cyclodextrin inclusion complex following peroral administration.

    abstract::16-Dehydropregnenolone (16-DHP) is an active compound with an unsatisfied in vivo behavior and poor water-solubility, which limits its clinical application. To improve its in vivo behavior and water-solubility, a Hydroxypropyl-beta-Cyclodextrin (HP-β-CD) inclusion complex of 16-DHP was prepared in this paper. Pharmaco...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1080/10837450.2016.1193192

    authors: Sun Y,Jia L,Zhou H,Mao M,Wang X,Wei L,Sun L

    更新日期:2017-03-01 00:00:00

  • Solid-state characterization of fluconazole.

    abstract::Two polymorphs and three solvates of fluconazole were isolated and characterized by x-ray powder diffractometry, IR spectroscopy, differential scanning calorimetry (DSC), thermogravimetry, and their dissolution rates. The different forms were prepared by crystallization of the original powder in different solvents at ...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1081/pdt-120015052

    authors: Alkhamis KA,Obaidat AA,Nuseirat AF

    更新日期:2002-11-01 00:00:00

  • Preparation of nanoparticles by solvent displacement using a novel recirculation system.

    abstract::Submicron colloidal suspensions of poly(epsilon-caprolactone) (PCL) were prepared by the solvent displacement method, using either the conventional form or a new recirculation device. In the latter case, a process that allows the recirculation of the aqueous phase into a device, providing a continuous flow, is propose...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1080/10837450600940824

    authors: Piñón-Segundo E,Ganem-Quintanar A,Rafael Garibay-Bermúdez J,Juan Escobar-Chávez J,López-Cervantes M,Quintanar-Guerrero D

    更新日期:2006-01-01 00:00:00

  • Complexation and solubility behavior of albendazole with some cyclodextrins.

    abstract::The main purpose of this work was to study the albendazole-cyclodextrins complexation equilibrium and to propose a suitable excipient to improve the solubility behavior and dissolution rate of albendazole. The complexation of albendazole with four cyclodextrins, alpha-CD, beta-CD, gamma-CD, and hydroxypropylated (HP)-...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837459809009867

    authors: Díaz D,Bernad Bernad MJ,Gracia Mora J,Escobar Llanos CM

    更新日期:1998-08-01 00:00:00

  • Preparation and in vitro characterization of diltiazem hydrochloride loaded alginate microspheres.

    abstract::The main objective of the present study was to improve bioavailability of diltiazem hydrochloride and decrease the frequency of dosage form administration by increasing the encapsulation efficiency of the drug, residence time of the dosage form at the site of absorption and sustained release of the drug from the deliv...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1080/10837450802626304

    authors: Sultana Y,Mall S,Maurya DP,Kumar D,Das M

    更新日期:2009-01-01 00:00:00

  • Effect of sample preparation method on quantification of polymorphs using PXRD.

    abstract::The purpose of this study was to improve the sensitivity and accuracy of quantitative analysis of polymorphic mixtures. Various techniques such as hand grinding and mixing (in mortar and pestle), air jet milling and ball milling for micronization of particle and mixing were used to prepare binary mixtures. Using these...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837450903286511

    authors: Alam S,Patel S,Bansal AK

    更新日期:2010-09-01 00:00:00

  • Isolation technology for research and development applications: from concept to production.

    abstract::A prototype parenteral manufacturing facility based on isolation technology was designed, constructed, and commissioned at Warner-Lambert Co., Morris Plains, NJ, with emphasis on its application to research and development (R&D) settings. The facility contains closed isolators for holding, transferring, and manufactur...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1081/pdt-100102034

    authors: Krishna AK,Lodhi SA,Harris MR

    更新日期:2000-01-01 00:00:00

  • Formulation and in vitro characterization of poly(dl-lactide-co-glycolide)/Eudragit RLPO or RS30D nanoparticles as an oral carrier of levofloxacin hemihydrate.

    abstract::The main objective of this study was to design positively charged Levofloxacin Hemihydrate (Levo-h)-loaded nanoparticles with improved entrapment efficiency and antibacterial activity. PLGA alone or in combinations with Eudragit® RLPO or RS30D with or without positively charged inducing agent; 1,2-dioleoyl-3-trimethyl...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837450.2015.1041044

    authors: Hasan AA,Sabry SA,Abdallah MH,El-Damasy DA

    更新日期:2016-09-01 00:00:00

  • Doxorubicin hydrochloride loaded nanotextured films as a novel drug delivery platform for ovarian cancer treatment.

    abstract::An approach for cancer treatment is modulation of tumor microenvironment. Based on the role of extracellular matrix in cell modulation, fabrication of textured materials mimicking extracellular matrix could provide novel opportunities such as determining cancer cell behaviour. With this background, in this work, we ha...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1080/10837450.2020.1823992

    authors: Yaşayan G,Mega Tiber P,Orun O,Alarçin E

    更新日期:2020-12-01 00:00:00

  • Novel organogels for topical delivery of naproxen: design, physicochemical characteristics and in vitro drug permeation.

    abstract::Taking into account possible irritation of the skin upon contact with naproxen (NPX) crystals and lower bioavailability after administration of the suspended or ionized drug, the aim of the work was to design and characterize novel and easy-to-formulate gels with the entirely dissolved drug in the acidic form. The for...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837450.2015.1135342

    authors: Osmałek T,Milanowski B,Froelich A,Górska S,Białas W,Szybowicz M,Kapela M

    更新日期:2017-06-01 00:00:00

  • The solution, solid state stability and kinetic investigation in degradation studies of lercanidipine: study of excipients compatibility of lercanidipine.

    abstract::The objectives of this research were to evaluate the stability of lercanidipine in solution state and solid state and explore the compatibility of drug with oils, surfactants and cosurfactants as excipients. The effect of pH on the degradation in solution state was studied through pH-rate profile of lercanidipine in c...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837450.2011.580758

    authors: Parmar N,Amin S,Singla N,Kohli K

    更新日期:2012-11-01 00:00:00

  • Formulation strategy of nitrofurantoin: co-crystal or solid dispersion?

    abstract::Poor solubility and bioavailability of drugs are often affected by its microscopic structural properties. Nitrofurantoin (NF), a Biopharmaceutics Classification System class II item, has a low water solubility with low plasma concentrations. To improve its therapeutic efficacy, formulation strategy of solid dispersion...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1080/10837450.2019.1689401

    authors: Teoh XY,Bt Mahyuddin FN,Ahmad W,Chan SY

    更新日期:2020-02-01 00:00:00

  • Formulation and physicochemical characterization of chitosan/acyclovir co-crystals.

    abstract::In the current study, the influence of chitosan on the dissolution rate and bioavailability of acyclovir has been illustrated through the preparation of co-crystals by simple solvent change method. Chitosan was precipitated on acyclovir crystals using sodium citrate as the salting out agent. The pure drug and the prep...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837450.2011.595798

    authors: Allam AN,Naggar VF,El Gamal SS

    更新日期:2013-07-01 00:00:00

  • Development of controlled-release SK&F 82526-J buffer bead formulations with tartaric acid as the buffer.

    abstract::The purpose of this research was to design and develop a novel controlled-release bead formulation for oral administration with buffer crystals as a carrier for loading of fenoldopam mesylate, an intravenous antihypertensive agent, which provides an in vitro release rate of 30-50 mg/hr for 6-8 hr. Buffer crystals were...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837459809028629

    authors: Venkatesh GM

    更新日期:1998-11-01 00:00:00

  • Alfuzosin hydrochloride-loaded low-density gastroretentive sponges: development, in vitro characterization and gastroretentive monitoring in healthy volunteers via MRI.

    abstract::The current work aimed to develop low-density gastroretentive sponges loaded with alfuzosin HCl (ALF) to sustain the rate of drug release, improve its oral bioavailability and deliver it to the main site of absorption. Sponges were developed, according to a 23 full factorial design, by compression of the lyophilized A...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1080/10837450.2020.1720235

    authors: Abd El-Aziz MF,Ismail S,Tadros MI,Elnabarawi MA

    更新日期:2020-06-01 00:00:00

  • Phase transition of a microemulsion upon addition of cyclodextrin - applications in drug delivery.

    abstract::This study reports on the impact of cyclodextrin addition on the phase behavior of microemulsion systems. Three distinct oil-in-water microemulsions were formulated and subjected to increasing concentrations of various cyclodextrins. The prepared formulations underwent visual, textural and microscopic characterization...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1080/10837450.2017.1371191

    authors: Thakur SS,Solloway J,Stikkelman A,Seyfoddin A,Rupenthal ID

    更新日期:2018-02-01 00:00:00

  • The effect of composition on the tableting indices of binary powder mixtures.

    abstract::The purpose of this study was to investigate the effect of the composition of a binary powder mixture on the bonding index, the brittle fracture index, and the strain index, as defined by Hiestand. The studies involved tensile strength and dynamic indentation hardness determinations of square compacts, the solid fract...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837459709022630

    authors: Majuru S,Wurster DE

    更新日期:1997-11-01 00:00:00

  • Physiological parameters of the gastrointestinal fluid impact the dissolution behavior of the BCS class IIa drug valsartan.

    abstract::The objective of this study was to investigate the effect of the physiological parameters (pH, buffer capacity, and ionic strength) of the gastrointestinal (GI) fluid on the dissolution behavior of the class II weakly acidic (BCS class IIa) drug valsartan. A series of in vitro dissolution studies was carried out on Di...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.1080/10837450.2018.1536996

    authors: Hamed R

    更新日期:2018-12-01 00:00:00

  • Bioavailability testing of a newly developed clindamycin oral suspension in a pediatric porcine model.

    abstract::Background: Clindamycin's bitter taste and odor is known to affect treatment adherence in children. Recently, a formulation of clindamycin HCl complexed with ion exchange resin IRP 69 was shown to mask the bitter taste. Because of the potential benefit of this formulation for children, a pilot study using a porcine mo...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/10837450.2019.1624771

    authors: Goode GA,Wagh SJ,Irby DJ,Ma D,Jacobs RF,Kearns GL,Almoazen H

    更新日期:2019-10-01 00:00:00

  • Improvement of the material motion in a rotary processor.

    abstract::The purpose of this paper is to reject or to confirm the hypothesis that the influence of the water addition rate on the size and size distribution of pellets is caused by insufficient spreading of the added water at higher water addition rates. To overcome insufficient spreading of the added water, the agitation in t...

    journal_title:Pharmaceutical development and technology

    pub_type: 杂志文章

    doi:10.3109/10837459609031431

    authors: Vertommen J,Jaucot B,Rombaut P,Kinget R

    更新日期:1996-12-01 00:00:00