Abstract:
:Flecainide base is pharmaceutically active substance used for production of flecainide acetate which is known in market as Tambacor, Almarytm, Apocard, Ecrinal or Flecaine. It is determined that flecainide base forms four polymorphic forms abbreviated as Ib, IIb, IIIb and IVb. Flecainide base form Ib is thermodynamically stable form at laboratory temperature while form IIIb is stable at higher temperatures. Flecainide form Ib absorbs water in its structure between layers and forms non-stoichiometric hydrate. Flecainide base binds with organic solvents and form monosolvates. Flecainide base form Ib crystallizes in orthorhombic crystals with lattice parameters a = 27.88 Å, b = 13.78 Å, c = 9.98 Å and two independent molecules in unit cell (Z' = 2; Z = 8). Molecule arrangement in flecainide base form Ib structure is not dense and it forms a channel-type structure, where molecules of water and alcohols are placed.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Veldre K,Eglīte Z,Actiņš A,Zvirgzdiņš A,Rozenberga L,Tamanis Edoi
10.3109/10837450.2013.763259subject
Has Abstractpub_date
2014-02-01 00:00:00pages
116-24issue
1eissn
1083-7450issn
1097-9867journal_volume
19pub_type
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