One-step preparation of ibuprofen fast- and sustained-release formulation by electrospinning with improved efficacy and reduced side effect.

abstract：:The objective of this study was to prepare pellets of thyme (Thymus vulgaris L.), stinging nettle (Urtica dioica L.) and sage (Salvia officinalis L.) dry extracts by extrusion-spheronization technique to improve technological properties and investigate dissolution profiles of pellets covered different levels of pH-sen...

journal_title：Pharmaceutical development and technology

authors： Kaledaite R,Bernatoniene J,Dvořáčková K,Gajdziok J,Muselík J,Pečiūra R,Masteikova R

更新日期：2015-11-01 00:00:00

abstract：:This study examines the effect of the degree of methoxylation (DM) and particle size on compression properties and compactibility of pectin powders. A powder classification system based on sequential handling of compression parameters was applied. A single size fraction (90-125 μm) of pectin powders with DM values ran...

journal_title：Pharmaceutical development and technology

authors： Salbu L,Bauer-Brandl A,Alderborn G,Tho I

更新日期：2012-05-01 00:00:00

abstract：:Bupivacaine lipid microparticles were prepared and evaluated as a parenteral sustained-release dosage form for postoperative pain management. Bupivacaine free base was incorporated into a molten tristearin matrix and lipid micro-particles were subsequently formed from this molten mixture by a spray-congealing process....

journal_title：Pharmaceutical development and technology

authors： Li LC,Zhu L,Song JF,Deng JS,Bandopadhyay R,Wurster DE

更新日期：2005-01-01 00:00:00

abstract：:Alpha lipoic acid (ALA), an active substance in anti-aging products and dietary supplements, need to be masked with an edible polymer to obscure its unpleasant taste. However, the high viscosity of the ALA molecules prevents them from forming microcomposites with masking materials even in supercritical carbon dioxide ...

journal_title：Pharmaceutical development and technology

authors： Mishima K,Honjo M,Sharmin T,Ito S,Kawakami R,Kato T,Misumi M,Suetsugu T,Orii H,Kawano H,Irie K,Sano K,Mishima K,Harada T,Ouchi M

更新日期：2016-09-01 00:00:00

abstract：:The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. Fluvastatin (FLV) samples were characterized by several techniqu...

journal_title：Pharmaceutical development and technology

authors： Borgmann SH,Bernardi LS,Rauber GS,Oliveira PR,Campos CE,Monti G,Cuffini SL,Cardoso SG

更新日期：2013-03-01 00:00:00

abstract：:The present work investigated the magnitude of microsphere-induced acute myotoxicity and determined whether this myotoxicity is related to microsphere size and/or reconstitution solvent. Using a high molecular weight poly(dl-lactide-co-glycolide) copolymer, the myotoxicity of two different size microsphere formulation...

journal_title：Pharmaceutical development and technology

authors： Brazeau GA,Sciame M,al-Suwayeh SA,Fattal E

更新日期：1996-10-01 00:00:00

abstract：:The present study was aimed to develop a matrix-type transdermal formulation of pentazocine using mixed polymeric grades of Eudragit RL/RS. The possible interaction between drug and polymer used were characterized by FTIR, DSC and X-RD. X-RD study indicates a change of state of drug from crystalline to amorphous in th...

journal_title：Pharmaceutical development and technology

authors： Chandak AR,Prasad Verma PR

更新日期：2010-06-01 00:00:00

abstract：CONTEXT:Freeze-drying in presence of excipients is a common practice to stabilize biomacromolecular formulations. The composition of this formulation is known to affect the quality of the final product. OBJECTIVE:The aim of this study was to evaluate freeze-drying in well-plates as a high throughput platform for formu...

journal_title：Pharmaceutical development and technology

authors： Trnka H,Rantanen J,Grohganz H

更新日期：2015-01-01 00:00:00

abstract：:Microporous polymeric matrices prepared from poly(ɛ-caprolactone) [PCL] were evaluated for controlled vaginal delivery of the antiprotozoal agent (tinidazole) in the treatment of the sexually transmitted infection, trichomoniasis. The matrices were produced by rapidly cooling co-solutions of PCL and tinidazole in acet...

journal_title：Pharmaceutical development and technology

authors： Fernando HV,Chan LL,Dang N,Santhanes D,Banneheke H,Nalliah S,Coombes AGA

更新日期：2019-03-01 00:00:00

abstract：:Objective: A polymer-based nanoparticle was constructed to target sorafenib delivery to colorectal carcinoma cells and decrease the side effects of the drug.Methods: Sorafenib-loaded nanoparticles (S-NPs) based on PEG-PLGA were prepared using a double emulsion solvent evaporation method. The properties of S-NPs were e...

journal_title：Pharmaceutical development and technology

authors： Li N,Chen Y,Sun H,Huang T,Chen T,Jiang Y,Yang Q,Yan X,Wu M

更新日期：2020-06-01 00:00:00

abstract：:The compendial method of evaluation of orodispersible tablets (ODT) is the same disintegration test as for conventional tablets. Since it does not reflect the disintegration process in the oral cavity, alternative methods are proposed that are more related to in vivo conditions, e.g. modified dissolution paddle appara...

journal_title：Pharmaceutical development and technology

authors： Brniak W,Jachowicz R,Krupa A,Skorka T,Niwinski K

更新日期：2013-03-01 00:00:00

abstract：:The dry coating process was evaluated in terms of storage stability investigating drug release and agglomeration tendency of the different coated oral dosage forms; hydroxypropyl methylcellulose acetate succinate (HPMCAS) was used with triethylcitrate (TEC) as plasticizer and acetylated monoglyceride (Myvacet) as wett...

journal_title：Pharmaceutical development and technology

authors： Kablitz CD,Urbanetz NA

更新日期：2009-01-01 00:00:00

abstract：:Dissolution profiles of various multiparticulate controlled-release dosage forms prepared by applying lipophilic materials using a hot-melt coating technique were analyzed to determine release kinetics. The dosage forms were prepared using a novel solid dispersion hot-melt fluid bed coating method. Various lipophilic ...

journal_title：Pharmaceutical development and technology

authors： Griffin EN,Niebergall PJ

更新日期：1999-01-01 00:00:00

abstract：:The purpose of this study was to assess the impact of impurities in formulation components, antioxidants, formulation pH, and processing/packaging on the extent of color change associated with oxidation of danofloxacin injectable. The methods used in this study include reversed-phase HPLC, UV-VIS spectrophotometry, at...

journal_title：Pharmaceutical development and technology

authors： Kasraian K,Kuzniar AA,Wilson GG,Wood JA

更新日期：1999-01-01 00:00:00

abstract：:A preliminary study of the feasibility of using near-infrared spectroscopy (NIRS) for the offline simultaneous determination of metoprolol tartrate (MTP) and hydrochlorothiazide (HTZ) in powders and tablets has been carried out. An industrial tableting process was simulated using an instrumented tablet press replicato...

journal_title：Pharmaceutical development and technology

authors： Vranic BZ,Vandamme TF

更新日期：2015-01-01 00:00:00

abstract：:The objective of this study was to develop and evaluate a novel microemulsion based gel formulation containing tazarotene for targeted topical therapy of acne. Psudoternary phase diagrams were constructed to obtain the concentration range of oil, surfactant, and co-surfactant for microemulsion formation. The optimized...

journal_title：Pharmaceutical development and technology

authors： Patel MR,Patel RB,Parikh JR,Patel BG

更新日期：2016-12-01 00:00:00

abstract：:The present study was aimed to optimize capsulated unfolding type gastroretentive bilayer film constituting immediate release (IR) layer of amlodipine besylate and sustained release (SR) layer of atorvastatin calcium. A three-factor, three-level Box-Behnken-design was used to optimize bilayer film with dual-release ch...

journal_title：Pharmaceutical development and technology

authors： Porwal A,Dwivedi H,Pathak K

更新日期：2020-04-01 00:00:00

abstract：:The purpose of this study was to improve the sensitivity and accuracy of quantitative analysis of polymorphic mixtures. Various techniques such as hand grinding and mixing (in mortar and pestle), air jet milling and ball milling for micronization of particle and mixing were used to prepare binary mixtures. Using these...

journal_title：Pharmaceutical development and technology

authors： Alam S,Patel S,Bansal AK

更新日期：2010-09-01 00:00:00

abstract：:A paddle method for measurement of the disintegrating time of orally disintegrating tablets with rizatriptan benzoate as a model drug was evaluated. The paddle method employed a dissolution test assembly with tablets immersed in disintegrating medium through a fastened sinker. Paddle stirring rate, opening of the sink...

journal_title：Pharmaceutical development and technology

authors： Que L,Wu W,Cheng X,Hu T

更新日期：2006-01-01 00:00:00

abstract：:Novel fast-disintegrating multi-unit tablets (FDMUTs) were prepared to modify the release of lornoxicam (a potent non-steroidal anti-inflammatory drug with a short half-life) as well as to combine the advantages of multi-unit systems with the cost-effectiveness of compressed tablets. The proposed FDMUTs consisted of s...

journal_title：Pharmaceutical development and technology

authors： Aburahma MH,Hamza Yel-S

更新日期：2011-08-01 00:00:00

abstract：:The formulation of betamethasone-17-valerate (BV) into topical medicines presents a significant challenge for the formulation chemist. The substance is susceptible to acid and base catalyzed isomerization in aqueous environments, which results in valerate transesterification from carbon 17 to carbon 21 of the steroid ...

journal_title：Pharmaceutical development and technology

authors： Byrne J,Wyraz A,Velasco-Torrijos T,Reinhardt R

更新日期：2017-06-01 00:00:00

abstract：:Our previous study reported that the Design Expert® Software showed a beneficial role in the development of microemulsions (ME) for transdermal drug delivery. To fully confirm the reproducibility and the reliability of simultaneous optimal ME formulations, the optimal ME formulations predicted by the Design Expert® So...

journal_title：Pharmaceutical development and technology

authors： Duangjit S,Chairat W,Opanasopit P,Rojanarata T,Ngawhirunpat T

更新日期：2016-09-01 00:00:00

abstract：:A novel flavonoid-polysaccharide conjugate was synthesized by free radical grafting of quercetin on starch. The covalent insertion of quercetin in the polymeric chain was confirmed by FT-IR, DSC and fluorescence analyses, while an estimation of the amount of quercetin bound per g of polymer was obtained by the Folin-C...

journal_title：Pharmaceutical development and technology

authors： Cirillo G,Puoci F,Iemma F,Curcio M,Parisi OI,Spizzirri UG,Altimari I,Picci N

更新日期：2012-07-01 00:00:00

abstract：:It is well known that carriers can affect the dissolution of poorly soluble drugs. In this study, our aim was to investigate the dissolution enhancement of carbamazepine solid dispersed or mixed at different loading ratios in crospovidone, polyvinylpyrrolidone, and sodium starch glycolate. The physical state of the dr...

journal_title：Pharmaceutical development and technology

authors： Moneghini M,Voinovich D,Perissutti B,Princivalle F

更新日期：2002-01-01 00:00:00

abstract：:The purpose of this research was to design and develop a novel controlled-release bead formulation for oral administration with buffer crystals as a carrier for loading of fenoldopam mesylate, an intravenous antihypertensive agent, which provides an in vitro release rate of 30-50 mg/hr for 6-8 hr. Buffer crystals were...

journal_title：Pharmaceutical development and technology

authors： Venkatesh GM

更新日期：1998-11-01 00:00:00

abstract：:Dynamic image analysis (DIA) was used to measure particle diameter (D50) of in-process samples removed during fluid bed coating. A single, rapid measurement gave D50 to within 4 mum. Samples removed at intervals of 2% weight gain were readily distinguishable by DIA and by their drug release profiles. Drug release was ...

journal_title：Pharmaceutical development and technology

authors： Heinicke G,Schwartz JB

更新日期：2006-01-01 00:00:00

abstract：:The objective of this study was to investigate the effect of the physiological parameters (pH, buffer capacity, and ionic strength) of the gastrointestinal (GI) fluid on the dissolution behavior of the class II weakly acidic (BCS class IIa) drug valsartan. A series of in vitro dissolution studies was carried out on Di...

journal_title：Pharmaceutical development and technology

authors： Hamed R

更新日期：2018-12-01 00:00:00

abstract：:A carbopol 934P-based drug delivery system (AmDDS) was developed to achieve the dual-controlled delivery of Nonoxynol-9 (N-9), a spermicidal agent, and EDTA, a potentiator of spermicidal activity. This gel-type system made intimate contact with vaginal mucosa and maintained an effective drug concentration within the v...

journal_title：Pharmaceutical development and technology

authors： Lee CH,Chien YW

更新日期：1996-07-01 00:00:00

abstract：:Pulmonary delivery of peptides remains an important, noninvasive route of administration that is attractive because it offers high bioavailability and patient compliance. Optimization of particle characteristics for deposition in the deep regions of the lung after inhalation and retention of peptide stability are key ...

journal_title：Pharmaceutical development and technology

authors： Poursina N,Vatanara A,Rouini MR,Gilani K,Rouholamini Najafabadi A

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Oxaliplatin has long been used for the treatment of colorectal cancer via intra-venous infusion. In order to improve patient compliance, a solid dosage form for oral administration of oxaliplatin was prepared as nano-sized particles. METHOD:Nano oxaliplatin was prepared employing Fat Employing Supercritical...

journal_title：Pharmaceutical development and technology

authors： Lee SJ,Kim YH,Lee SH,Hahn M

更新日期：2012-03-01 00:00:00