Abstract:
BACKGROUND:Oxaliplatin has long been used for the treatment of colorectal cancer via intra-venous infusion. In order to improve patient compliance, a solid dosage form for oral administration of oxaliplatin was prepared as nano-sized particles. METHOD:Nano oxaliplatin was prepared employing Fat Employing Supercritical Nano System (FESNS(®)) with Supercritical Fluid (SCF) apparatus by using myristyl alcohol as solvent. Morphology of nano oxaliplatin was examined by Scanning Electron Microscopy (SEM), and the particle size and zeta potential were confirmed with Dynamic Light Scattering (DLS). To characterize the nano oxaliplatin particles, solubility rate and in vitro efficacy study (MTS growth inhibition assay) were investigated compared to crude oxaliplatin as reference. RESULT:FESNS(®) provided reproducible nano oxaliplatin with high manufacturing yield (> 95%). SEM images showed that the particle size distribution of nano oxaliplatin ranged between 20 and 400 nm with the medium particle sizes (d(50)) of about 164 nm determined by DLS. Pertaining to the long-term stability, no recrystallization of the nano oxaliplatin was observed with negative zeta potential in the state of solution. Nano oxaliplatin was completely dissolved within a couple of minutes in pH 4.0 and pH 6.8 buffer solutions while crude oxaliplatin took a couple of hours to go into solution. In case of MTS growth inhibition assay, the average concentration required to inhibit 50% of cell growth (GI(50)) of nano oxaliplatin was decreased by about 45% in comparison to the crude oxaliplatin. CONCLUSION:These results lead us to conclude that nano oxaliplatin would have a great potential for the improvement of efficacy and toxicity in human colorectal cancer treatment compared to the crude oxaliplatin.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Lee SJ,Kim YH,Lee SH,Hahn Mdoi
10.3109/10837450.2010.531735subject
Has Abstractpub_date
2012-03-01 00:00:00pages
212-8issue
2eissn
1083-7450issn
1097-9867journal_volume
17pub_type
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