Abstract：
:The current work aimed to develop low-density gastroretentive sponges loaded with alfuzosin HCl (ALF) to sustain the rate of drug release, improve its oral bioavailability and deliver it to the main site of absorption. Sponges were developed, according to a 23 full factorial design, by compression of the lyophilized ALF-loaded hydroxypropylmethylcellulose (HPMC) or chitosan (CH) solutions. The influences of the polymer type, grade and concentration on the appearance, topography, porosity, density, in vitro ALF release, floating behavior, swelling, erosion, and mucoadhesive potential of the developed sponges were explored. Based on the desirability value, the best achieved system was selected. The gastroretentive potential of this system was evaluated in healthy male volunteers via MRI. Soft and flexible sponges were developed. They were characterized with interconnecting pores and channels and had excellent floating properties with respect to floating lag time and duration. Compared to HPMC-based sponges, CH-based ones exhibited higher porosity, larger pore diameters, lower bulk densities, higher drug release rates, larger swelling ratios, faster erosion rates and better mucoadhesive properties. MRI of magnetite-loaded best-achieved CH-based system (F8) ascertained the development of a promising gastroretentive system; exhibiting a gastric residence period of at least 5 h.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Abd El-Aziz MF,Ismail S,Tadros MI,Elnabarawi MAdoi
10.1080/10837450.2020.1720235subject
Has Abstractpub_date
2020-06-01 00:00:00pages
566-578issue
5eissn
1083-7450issn
1097-9867journal_volume
25pub_type
杂志文章abstract：:The purpose of this study was to develop a benchtop apparatus to simulate the scale-up of the moist-heat sterilization process of sodium carboxymethylcellulose (CMC) gel and identify critical process parameters that affect the sterilized gel viscosity. A 600-ml benchtop Parr reactor was modified and used to achieve go...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1081/pdt-100101394
更新日期：1999-01-01 00:00:00
abstract：:Understanding variability in excipient physico-chemical properties is becoming an important aspect of Quality-by-Design drug product development. However, present experimental methods have only been able to study a few physico-chemical properties for a few excipient lots due to time, cost, and sample gathering conside...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2011.604784
更新日期：2013-03-01 00:00:00
abstract：:ABSTRCT Felodipine has been widely used as a poorly water-soluble model drug for various studies to improve its oral bioavailability and in vivo efficacy. In this study, we developed amorphous solid dispersions (ASDs) via spray drying to enhance the bioavailability of felodipine through using natural zein protein as a...
journal_title：Pharmaceutical development and technology
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doi：10.1080/10837450.2020.1809456
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journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450903055494
更新日期：2010-03-01 00:00:00
abstract：:Preterm labor is the main cause of death and serious illness of both infants and pregnant women in Africa and worldwide. Parenteral and oral salbutamol sulfate as a B2 antagonist has been used for the treatment of preterm labor. The study aims are to formulate salbutamol sulfate non-invasive vaginal bioadhesive tablet...
journal_title：Pharmaceutical development and technology
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doi：10.1080/10837450.2020.1767129
更新日期：2020-10-01 00:00:00
abstract：:An approach for cancer treatment is modulation of tumor microenvironment. Based on the role of extracellular matrix in cell modulation, fabrication of textured materials mimicking extracellular matrix could provide novel opportunities such as determining cancer cell behaviour. With this background, in this work, we ha...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450.2020.1823992
更新日期：2020-12-01 00:00:00
abstract：:This study investigates the physicochemical properties of glycyl-histidyl-lysine-copper (GHK-Cu) to support the development of a formulation for effective topical delivery. The solubility and distribution coefficients (log D) were investigated using conventional methods and GHK concentrations were quantified with a va...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2014.979944
更新日期：2016-03-01 00:00:00
abstract：:Submicron colloidal suspensions of poly(epsilon-caprolactone) (PCL) were prepared by the solvent displacement method, using either the conventional form or a new recirculation device. In the latter case, a process that allows the recirculation of the aqueous phase into a device, providing a continuous flow, is propose...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450600940824
更新日期：2006-01-01 00:00:00
abstract：:In pediatrics, it is crucial to ameliorate the unpleasant taste of oral pharmaceutical formulations in order to facilitate patient compliance. Scientists' attempt to develop modern products for children is included among the new trends in pharmaceutical technology. Designing the preparation procedures and selecting th...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450.2019.1609499
更新日期：2020-01-01 00:00:00
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journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2015.1081612
更新日期：2016-12-01 00:00:00
abstract：:The effect of some processing and formulation variables on the stability of tablets containing a crystalline salt of a triazine derivative was studied. The salt has a relatively low melting point and a low microenvironmental pH due to the weakly basic nature of the parent compound (pKa = 4.0). This compound decomposes...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1081/pdt-200031417
更新日期：2004-08-01 00:00:00
abstract：:In this study, we designed a polymersome system for the controlled release of methotrexate (MTX) as an anticancer drug with the objective of improving the loading efficiency of the drug in polymersomes as well as achievement of an efficient control on the release rate of drug from nanocarriers. We synthesized mono met...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450.2018.1425433
更新日期：2019-01-01 00:00:00
abstract：:Alendronate sodium (ALD) is a bisphosphonate medication used in the treatment and prevention of osteoporosis. Absorption of ALD as oral formulation is very poor (0.5%-1%). Its bioavailability can decrease with food effect. It has some gastrointestinal adverse effects such as gastritis, gastric ulcer, and esophagitis. ...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450801949509
更新日期：2008-01-01 00:00:00
abstract：:Magnesium stearate (MgSt) is a widely used pharmaceutical lubricant in tablet manufacturing. However, batch-to-batch variability in hydrate form and surface area can lead to inconsistency in tablet performance. In this work, several unique MgSt samples were studied: traditional monohydrate samples with high surface ar...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450.2020.1839763
更新日期：2021-02-01 00:00:00
abstract：:The aim of the present investigation was to develop and study topical gel delivery of curcumin for its anti-inflammatory effects. Carbopol 934P (CRB) and hydroxypropylcellulose (HPC) were used for the preparation of gels. The penetration enhancing effect of menthol (0-12.5% w/w) on the percutaneous flux of curcumin th...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450802409438
更新日期：2009-01-01 00:00:00
abstract：:A prototype parenteral manufacturing facility based on isolation technology was designed, constructed, and commissioned at Warner-Lambert Co., Morris Plains, NJ, with emphasis on its application to research and development (R&D) settings. The facility contains closed isolators for holding, transferring, and manufactur...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1081/pdt-100102034
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:The purpose of the present investigation was to prepare a plasma stable, pH-sensitive niosomal formulation to enhance Sirolimus efficacy and selectivity. MATERIALS AND METHODS:pH-sensitive niosomal formulations bearing PEG-Poly (monomethyl itaconate)-CholC6 (PEG-PMMI-CholC6) copolymers and cholesteryl hemisu...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2013.860553
更新日期：2015-05-01 00:00:00
abstract：:Microgels were prepared by cinnamic acid-gelatin (type B) conjugate (CA-GelB) and cinnamic acid-Pluronic F127 conjugate (CA-Plur). (1)H NMR confirmed that CA was conjugated to gelatin and the gelatin to CA residue molar ratio was estimated to be 1:4.7 by a colorimetric method. CA-Plur of which the CA residue to Plur m...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2014.999787
更新日期：2016-01-01 00:00:00
abstract：:In the pharmaceutical industry, chemometrics is rapidly establishing itself as a tool that can be used at every step of product development and beyond: from early development to commercialization. This set of multivariate analysis methods allows the extraction of information contained in large, complex data sets thus ...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章,评审
doi：10.3109/10837450.2014.898656
更新日期：2015-01-01 00:00:00
abstract：CONTEXT:Development and evaluation of thermosensitive and bioadhesive liquid suppositories containing ketoprofen (KP). OBJECTIVE:This study was conducted to develope thermosensitive and bioadhesive liquid suppositories containing KP using poloxamer and different bioadhesive polymers and to investigate their gelation t...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2013.846373
更新日期：2014-12-01 00:00:00
abstract：:Several processing and shipping stresses were investigated for their effect on the physical stability of recombinant human growth hormone (rhGH). These included exposure to air/water interfaces, adsorption to hydrophobic surfaces, freeze-thaw cycles, and temperature. The interfacially and thermally denatured hormone w...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837459709022619
更新日期：1997-05-01 00:00:00
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journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837459709022608
更新日期：1997-02-01 00:00:00
abstract：:The compendial method of evaluation of orodispersible tablets (ODT) is the same disintegration test as for conventional tablets. Since it does not reflect the disintegration process in the oral cavity, alternative methods are proposed that are more related to in vivo conditions, e.g. modified dissolution paddle appara...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2012.710238
更新日期：2013-03-01 00:00:00
abstract：:In this study, the degradation of Octastatin, a cyclic octapeptide analog of somatostatin, was examined as a function of pH, temperature, buffer, and ionic strength by reversed-phase gradient high-performance liquid chromatography. Degradation of Octastatin followed a first-order kinetics. Various buffer species such ...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837459709022640
更新日期：1997-11-01 00:00:00
abstract：:The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. Fluvastatin (FLV) samples were characterized by several techniqu...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2012.727000
更新日期：2013-03-01 00:00:00
abstract：:The present study was aimed to develop a matrix-type transdermal formulation of pentazocine using mixed polymeric grades of Eudragit RL/RS. The possible interaction between drug and polymer used were characterized by FTIR, DSC and X-RD. X-RD study indicates a change of state of drug from crystalline to amorphous in th...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450903188501
更新日期：2010-06-01 00:00:00
abstract：:The general solubility equation (GSE) is the state-of-the-art method for estimating the aqueous solubilities of organic compounds. It is an extremely simple equation that expresses aqueous solubility as a function of only two inputs: the octanol-water partition coefficient calculated by readily available softwares lik...
journal_title：Pharmaceutical development and technology
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doi：10.1080/10837450.2017.1321663
更新日期：2018-09-01 00:00:00
abstract：:A redox-responsive docetaxel (DTX) prodrug consisting of a disulfide linkage between DTX and vitamin E (DTX-SS-VE) was synthesized in our laboratory and was successfully formulated into liposomes. The aim of this study was to optimize the formulation and investigate the cellular uptake of DTX prodrug-loaded liposomes ...
journal_title：Pharmaceutical development and technology
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更新日期：2018-01-01 00:00:00
abstract：:Objective: Tanshinone IIA (TSN) and Tetramethylpyrazine (TMP) were combined in a composite, oil-in-water nanoemulsions (TSN/TMP O/W NEs) was prepared to prolong in vitro and vivo circulation time, and enhance the bioavailability of TSN. Material and methods: Physicochemical characterization of TSN/TMP O/W NEs was char...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450.2019.1656237
更新日期：2019-12-01 00:00:00
abstract：:The physicochemical properties and enzymatic stability of esters of phenylephrone, synthesized on the basis of the chemical delivery system (CDS) concept, were studied as a new class of mydriatic agents. Potentiometrically determined ionization constants (pKa) of the novel compounds were in the range 7.19-7.21. The th...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1081/pdt-100101353
更新日期：1999-05-01 00:00:00
