Properties of bioadhesive ketoprofen liquid suppositories: preparation, determination of gelation temperature, viscosity studies and evaluation of mechanical properties using texture analyzer by 4 × 4 factorial design.

abstract：:Background: Clindamycin's bitter taste and odor is known to affect treatment adherence in children. Recently, a formulation of clindamycin HCl complexed with ion exchange resin IRP 69 was shown to mask the bitter taste. Because of the potential benefit of this formulation for children, a pilot study using a porcine mo...

journal_title：Pharmaceutical development and technology

authors： Goode GA,Wagh SJ,Irby DJ,Ma D,Jacobs RF,Kearns GL,Almoazen H

更新日期：2019-10-01 00:00:00

abstract：:This paper assesses the cause of particulate formation in vials of the experimental antitumor agent bisnafide and investigates pharmaceutical techniques to reduce the number of particulates in the product. Solution preparation and particulate isolation were performed under Class 100 laminar air flow. Reversed-phase HP...

journal_title：Pharmaceutical development and technology

authors： Rubino JT,Chan LL,Walker JT,Segretario J,Everlof JG,Hussain MA

更新日期：1999-08-01 00:00:00

abstract：:The high initial burst release of a highly water-soluble drug from poly (D,L-lactide-co-glycolide) (PLGA) microparticles prepared by the multiple emulsion (w/o/w) solvent extraction/evaporation method was reduced by coating with an additional polymeric PLGA layer. Coating with high encapsulation efficiency was perform...

journal_title：Pharmaceutical development and technology

authors： Ahmed AR,Elkharraz K,Irfan M,Bodmeier R

更新日期：2012-01-01 00:00:00

abstract：:Ranitidine tablets USP showed variable intra- and inter-lab dissolution results. In order to ascertain the reason for this behavior, ranitidine tablets USP produced by (BIPI) Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, and Zantac Tablets (brand of ranitidine USP), Glaxo Inc., Research Triangle, NC, were...

journal_title：Pharmaceutical development and technology

authors： Cappola ML

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:To evaluate four novel metrics that compare dissolution profiles and assess their performance characteristics by comparing dissolution profiles of FAST and SLOW immediate release metoprolol tartrate tablets. METHODS:The four novel metrics (rho, rho m, delta a, and delta s), along with f2, were applied to disso...

journal_title：Pharmaceutical development and technology

authors： Seo PR,Shah VP,Polli JE

更新日期：2002-05-01 00:00:00

abstract：:The dry coating process was evaluated in terms of storage stability investigating drug release and agglomeration tendency of the different coated oral dosage forms; hydroxypropyl methylcellulose acetate succinate (HPMCAS) was used with triethylcitrate (TEC) as plasticizer and acetylated monoglyceride (Myvacet) as wett...

journal_title：Pharmaceutical development and technology

authors： Kablitz CD,Urbanetz NA

更新日期：2009-01-01 00:00:00

abstract：:Hypericin (Hyp), a natural hydrophobic and photoactive pigment, and methylene blue (MB), a hydrophilic cationic dye, are utilized as photosensitizer (PS) for photodynamic therapy of cancer. Bioadhesive and thermoresponsive polymeric systems can improve the drug availability by increasing the contact time between the s...

journal_title：Pharmaceutical development and technology

authors： Borghi-Pangoni FB,Junqueira MV,Bruschi ML

更新日期：2020-04-01 00:00:00

abstract：:The objective of the present study was to coprocess 2 active pharmaceutical ingredients (APIs), nevirapine (NVP) and stavudine (STV), by spray drying technique to overcome the respective problems of poor solubility and poor content uniformity. The coprocessed product (NVP-STV CP) and untreated APIs were characterized ...

journal_title：Pharmaceutical development and technology

authors： Mohammed GA,Puri V,Bansal AK

更新日期：2008-01-01 00:00:00

abstract：:In the current study, the influence of chitosan on the dissolution rate and bioavailability of acyclovir has been illustrated through the preparation of co-crystals by simple solvent change method. Chitosan was precipitated on acyclovir crystals using sodium citrate as the salting out agent. The pure drug and the prep...

journal_title：Pharmaceutical development and technology

authors： Allam AN,Naggar VF,El Gamal SS

更新日期：2013-07-01 00:00:00

abstract：:Taking into account possible irritation of the skin upon contact with naproxen (NPX) crystals and lower bioavailability after administration of the suspended or ionized drug, the aim of the work was to design and characterize novel and easy-to-formulate gels with the entirely dissolved drug in the acidic form. The for...

journal_title：Pharmaceutical development and technology

authors： Osmałek T,Milanowski B,Froelich A,Górska S,Białas W,Szybowicz M,Kapela M

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:Theoretical models of the freeze-drying process are potentially useful to guide the design of a freeze-drying process as well as to obtain information not readily accessible by direct experimentation, such as moisture distribution and glass transition temperature, Tg, within a vial during processing. Previ...

journal_title：Pharmaceutical development and technology

authors： Pikal MJ,Cardon S,Bhugra C,Jameel F,Rambhatla S,Mascarenhas WJ,Akay HU

更新日期：2005-01-01 00:00:00

abstract：:The objective of the present investigation was to formulate and evaluate orodispersible tablets (ODTs) of ondansetron HCl possessing sufficient mechanical strength by wet granulation or direct compression method. A combination of glycine and chitosan was employed for providing a sweet tasting disintegrating system. Th...

journal_title：Pharmaceutical development and technology

authors： Goel H,Vora N,Tiwary AK,Rana V

更新日期：2009-01-01 00:00:00

abstract：:Purpose: Intestinal drug absorption is one of the main factors that govern the fraction of oral dose absorbed (Fa) of drugs. It is reported that oral absorption of bortezomib (BTZ) can be restricted by its low intestinal permeability. In this study, we aimed to evaluate the impact of self-nanoemulsifying drug delivery...

journal_title：Pharmaceutical development and technology

authors： Mahmoudian M,Valizadeh H,Löbenberg R,Zakeri-Milani P

更新日期：2020-03-01 00:00:00

abstract：:The contact time of a vehicle on the cornea is of utmost importance for ophthalmic drug delivery. The poor bioavailability and therefore poor therapeutic response exhibited by the conventional ophthalmic solutions due to pre-corneal elimination of a drug may be overcome by the use of the in situ gel forming systems, w...

journal_title：Pharmaceutical development and technology

authors： Gupta S,Samanta MK

更新日期：2010-07-01 00:00:00

abstract：:The oral administration route is considered to be the most widely used route because of its convenience of administration and manufacturing. Dosage forms, like orally disintegrating tablets (ODTs), mini tablets, and orally disintegrating mini tablets (ODMTs), are recognized as promising for use in pediatric patients. ...

journal_title：Pharmaceutical development and technology

authors： Comoglu T,Dilek Ozyilmaz E

更新日期：2019-09-01 00:00:00

abstract：:The formulation of betamethasone-17-valerate (BV) into topical medicines presents a significant challenge for the formulation chemist. The substance is susceptible to acid and base catalyzed isomerization in aqueous environments, which results in valerate transesterification from carbon 17 to carbon 21 of the steroid ...

journal_title：Pharmaceutical development and technology

authors： Byrne J,Wyraz A,Velasco-Torrijos T,Reinhardt R

更新日期：2017-06-01 00:00:00

abstract：:The main objective of this study was to design positively charged Levofloxacin Hemihydrate (Levo-h)-loaded nanoparticles with improved entrapment efficiency and antibacterial activity. PLGA alone or in combinations with Eudragit® RLPO or RS30D with or without positively charged inducing agent; 1,2-dioleoyl-3-trimethyl...

journal_title：Pharmaceutical development and technology

authors： Hasan AA,Sabry SA,Abdallah MH,El-Damasy DA

更新日期：2016-09-01 00:00:00

abstract：:The aim of this study was to investigate isotropic mono- and diglyceride-based (MCMDG) systems, which are potential vehicles for injectable products containing both hydrophilic and lipophilic drugs. For two-component systems, MCMDG was mixed with various masses of water. For three-component systems, the samples were p...

journal_title：Pharmaceutical development and technology

authors： Sari P,Razzak M,Tucker IG

更新日期：2004-01-01 00:00:00

abstract：:A carbopol 934P-based drug delivery system (AmDDS) was developed to achieve the dual-controlled delivery of Nonoxynol-9 (N-9), a spermicidal agent, and EDTA, a potentiator of spermicidal activity. This gel-type system made intimate contact with vaginal mucosa and maintained an effective drug concentration within the v...

journal_title：Pharmaceutical development and technology

authors： Lee CH,Chien YW

更新日期：1996-07-01 00:00:00

abstract：CONTEXT:Freeze-drying in presence of excipients is a common practice to stabilize biomacromolecular formulations. The composition of this formulation is known to affect the quality of the final product. OBJECTIVE:The aim of this study was to evaluate freeze-drying in well-plates as a high throughput platform for formu...

journal_title：Pharmaceutical development and technology

authors： Trnka H,Rantanen J,Grohganz H

更新日期：2015-01-01 00:00:00

abstract：:To develop an effective therapeutic treatment, the potential of poly (lactic-co-glycolic acid)-polyethylene glycol-retinoic acid (PLGA-PEG-RA) polymeric micelles for targeted delivery of irinotecan to hepatocellular carcinoma (HepG2) and colorectal cancer cell lines (HT-29) was evaluated. PLGA-PEG-RA was synthesized b...

journal_title：Pharmaceutical development and technology

authors： Emami J,Maghzi P,Hasanzadeh F,Sadeghi H,Mirian M,Rostami M

更新日期：2018-01-01 00:00:00

abstract：:The compendial method of evaluation of orodispersible tablets (ODT) is the same disintegration test as for conventional tablets. Since it does not reflect the disintegration process in the oral cavity, alternative methods are proposed that are more related to in vivo conditions, e.g. modified dissolution paddle appara...

journal_title：Pharmaceutical development and technology

authors： Brniak W,Jachowicz R,Krupa A,Skorka T,Niwinski K

更新日期：2013-03-01 00:00:00

abstract：:A paddle method for measurement of the disintegrating time of orally disintegrating tablets with rizatriptan benzoate as a model drug was evaluated. The paddle method employed a dissolution test assembly with tablets immersed in disintegrating medium through a fastened sinker. Paddle stirring rate, opening of the sink...

journal_title：Pharmaceutical development and technology

authors： Que L,Wu W,Cheng X,Hu T

更新日期：2006-01-01 00:00:00

abstract：:Photon correlation spectroscopy (PCS) is compared with classic rheological measurements using the cone-and-plate technique for the determination of the viscosity of protein solutions. The potential advantages using PCS are small sample volume and fast determination of zero-shear viscosity. The present study assesses p...

journal_title：Pharmaceutical development and technology

authors： Wagner M,Reiche K,Blume A,Garidel P

更新日期：2013-07-01 00:00:00

abstract：:A colchicine release system utilizing biodegradable poly(phosphazenes) was investigated in vitro for intra-articular administration. Polymer degradation and drug release studies were performed on colchicine-loaded poly(phosphazenes) containing either imidazolyl (I-PPHOS) or ethyl glycinato (EG-PPHOS) side chain substi...

journal_title：Pharmaceutical development and technology

authors： Ibim SM,el-Amin SF,Goad ME,Ambrosio AM,Allcock HR,Laurencin CT

更新日期：1998-02-01 00:00:00

abstract：:Multivesicular liposomes (MVLs) have been widely studied for encapsulation of hydrophilic drugs due to their structural properties and large aqueous inner cavities. In this study, to investigate MVLs and their potential application for incorporation of hydrophobic drugs, new drug delivery system for fluocinolone aceto...

journal_title：Pharmaceutical development and technology

authors： Vafaei SY,Dinarvand R,Esmaeili M,Mahjub R,Toliyat T

更新日期：2015-11-01 00:00:00

abstract：:The biopharmaceutical assessment of new drug candidates based on their chemical structure is important in drug discovery and development. The scope of this study is to focus on lipophilic drugs and to clarify the role of their chemical predictors on oral bioavailability in humans. First their chemical properties were ...

journal_title：Pharmaceutical development and technology

authors： Kuentz MT,Arnold Y

更新日期：2009-01-01 00:00:00

abstract：:The aim of this study was to prepare various types of solid dispersions (SDs) by the hot-melt extrusion technique. Next, process analytical technology (PAT) such as Fourier transform-infrared (FT-IR) and Raman and near infrared (NIR) spectroscopy were applied to determine the solubilization effect. The SDs and its tab...

journal_title：Pharmaceutical development and technology

authors： Hwang I,Renuka V,Lee JH,Weon KY,Kang CY,Lee BJ,Park JB

更新日期：2020-06-01 00:00:00

abstract：:Flecainide base is pharmaceutically active substance used for production of flecainide acetate which is known in market as Tambacor, Almarytm, Apocard, Ecrinal or Flecaine. It is determined that flecainide base forms four polymorphic forms abbreviated as Ib, IIb, IIIb and IVb. Flecainide base form Ib is thermodynamica...

journal_title：Pharmaceutical development and technology

authors： Veldre K,Eglīte Z,Actiņš A,Zvirgzdiņš A,Rozenberga L,Tamanis E

更新日期：2014-02-01 00:00:00

abstract：:The current work aimed to develop low-density gastroretentive sponges loaded with alfuzosin HCl (ALF) to sustain the rate of drug release, improve its oral bioavailability and deliver it to the main site of absorption. Sponges were developed, according to a 23 full factorial design, by compression of the lyophilized A...

journal_title：Pharmaceutical development and technology

authors： Abd El-Aziz MF,Ismail S,Tadros MI,Elnabarawi MA

更新日期：2020-06-01 00:00:00