Abstract：
:In the current study, the influence of chitosan on the dissolution rate and bioavailability of acyclovir has been illustrated through the preparation of co-crystals by simple solvent change method. Chitosan was precipitated on acyclovir crystals using sodium citrate as the salting out agent. The pure drug and the prepared co-crystals using different concentrations and molecular weights of chitosan were characterized in terms of drug content, particle size, thermal behavior, IR analysis, surface morphology, in vitro drug release and physical stability. The results obtained showed that the practical yield of the prepared co-crystals was found to be inversely proportional to chitosan concentration. The drug content of the co-crystals was uniform among the different batches. The prepared co-crystals showed a slower drug release when compared to that of pure drug. The considerable change in the dissolution rate of acyclovir from optimized crystal formulation was attributed to the wetting effect of chitosan, the reduction in drug crystallinity and the altered surface morphology. The thermograms showed a decrease in the melting enthalpy of acyclovir indicating a disorder in the crystalline content whereas IR spectroscopy studies revealed an interaction between acyclovir and chitosan. The optimized co-crystals were stable for three months at 40°C and 75 ± 5% RH.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Allam AN,Naggar VF,El Gamal SSdoi
10.3109/10837450.2011.595798subject
Has Abstractpub_date
2013-07-01 00:00:00pages
856-65issue
4eissn
1083-7450issn
1097-9867journal_volume
18pub_type
杂志文章abstract：:The aim of this study was to investigate isotropic mono- and diglyceride-based (MCMDG) systems, which are potential vehicles for injectable products containing both hydrophilic and lipophilic drugs. For two-component systems, MCMDG was mixed with various masses of water. For three-component systems, the samples were p...
journal_title：Pharmaceutical development and technology
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doi：10.1081/pdt-120027422
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abstract：:Several processing and shipping stresses were investigated for their effect on the physical stability of recombinant human growth hormone (rhGH). These included exposure to air/water interfaces, adsorption to hydrophobic surfaces, freeze-thaw cycles, and temperature. The interfacially and thermally denatured hormone w...
journal_title：Pharmaceutical development and technology
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doi：10.3109/10837459709022619
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abstract：:The objective of the study was to mask the unpleasant taste of captopril (CPT). Taste masking was achieved by complexation of CPT with a basic ion exchange resin, Dowex® 66, using the batch method. Dowex® 66 was used for the adsorption of CPT, and physical and chemical parameters of the CPT resinates complex were eval...
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journal_title：Pharmaceutical development and technology
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journal_title：Pharmaceutical development and technology
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journal_title：Pharmaceutical development and technology
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journal_title：Pharmaceutical development and technology
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更新日期：2012-11-01 00:00:00
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journal_title：Pharmaceutical development and technology
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journal_title：Pharmaceutical development and technology
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journal_title：Pharmaceutical development and technology
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doi：10.3109/10837450.2011.565347
更新日期：2012-09-01 00:00:00
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journal_title：Pharmaceutical development and technology
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journal_title：Pharmaceutical development and technology
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journal_title：Pharmaceutical development and technology
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journal_title：Pharmaceutical development and technology
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journal_title：Pharmaceutical development and technology
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更新日期：1998-05-01 00:00:00
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journal_title：Pharmaceutical development and technology
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journal_title：Pharmaceutical development and technology
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更新日期：2002-01-01 00:00:00
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journal_title：Pharmaceutical development and technology
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更新日期：2004-01-01 00:00:00
abstract：:A colchicine release system utilizing biodegradable poly(phosphazenes) was investigated in vitro for intra-articular administration. Polymer degradation and drug release studies were performed on colchicine-loaded poly(phosphazenes) containing either imidazolyl (I-PPHOS) or ethyl glycinato (EG-PPHOS) side chain substi...
journal_title：Pharmaceutical development and technology
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更新日期：1998-02-01 00:00:00
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journal_title：Pharmaceutical development and technology
pub_type： 杂志文章,评审
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更新日期：2017-06-01 00:00:00
