Understanding the mechanism for paradoxical effect of ionized and unionized chitosan: Orodispersible tablets of Ondansetron Hydrochloride.

abstract：:The compendial method of evaluation of orodispersible tablets (ODT) is the same disintegration test as for conventional tablets. Since it does not reflect the disintegration process in the oral cavity, alternative methods are proposed that are more related to in vivo conditions, e.g. modified dissolution paddle appara...

journal_title：Pharmaceutical development and technology

authors： Brniak W,Jachowicz R,Krupa A,Skorka T,Niwinski K

更新日期：2013-03-01 00:00:00

abstract：:The aim of the present work was the development of vaginal sponge-like dressings based on chitosan ascorbate (CS) and on hyaluronic acid sodium salt/lysine acetate (HAS) combination. Sponge-like dressings were prepared by freeze-drying and characterized for mechanical resistance and mucoadhesion. CS dressings show hig...

journal_title：Pharmaceutical development and technology

authors： Rossi S,Marciello M,Ferrari F,Puccio A,Bonferoni C,Sandri G,Caramella C

更新日期：2012-03-01 00:00:00

abstract：:The unstirred aqueous boundary layer (ABL) thickness was determined for modified Franz diffusion cells using three test compounds--parathion, 4-hexylresorcinol, and 2,4-dinitrochlorobenzene (DNCB). Steady-state fluxes through one, two, and three dialysis membranes in series were achieved in donor-saturated, infinite-d...

journal_title：Pharmaceutical development and technology

authors： Miller MA,Kasting G

更新日期：2012-11-01 00:00:00

abstract：:Bupivacaine lipid microparticles were prepared and evaluated as a parenteral sustained-release dosage form for postoperative pain management. Bupivacaine free base was incorporated into a molten tristearin matrix and lipid micro-particles were subsequently formed from this molten mixture by a spray-congealing process....

journal_title：Pharmaceutical development and technology

authors： Li LC,Zhu L,Song JF,Deng JS,Bandopadhyay R,Wurster DE

更新日期：2005-01-01 00:00:00

abstract：:There is as yet no commercialized preparation for oral administration of flecainide acetate (FA) to children. In such cases, manipulation of commercial tablets is the usual practice in pharmacy services of hospitals and compounding pharmacies, to provide a suitable dosage form for this vulnerable pediatric population ...

journal_title：Pharmaceutical development and technology

authors： Santoveña A,Charola I,Suárez-González J,Teigell-Pérez N,García-van Nood S,Soriano M,Fariña JB

更新日期：2018-12-01 00:00:00

abstract：:In recent years, drug delivery systems such as liposomes and microparticles have been used in clinic for the treatment of different diseases and from a regulatory point of view, a parenterally applied drug and drug delivery systems must be sterile and pyrogen free. Radiation sterilization is a method recognized by pha...

journal_title：Pharmaceutical development and technology

authors： Sakar F,Özer AY,Erdogan S,Ekizoglu M,Kart D,Özalp M,Colak S,Zencir Y

更新日期：2017-09-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cause of cancer-related death in both men and women. Often, surgical intervention remains the choice in treating CRC. Traditional dosage forms used for treating CRC deliver drug to wanted as well as unwanted sites of drug action resulting in several adverse side effects...

journal_title：Pharmaceutical development and technology

authors： Krishnaiah YS,Khan MA

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:The purpose of the present investigation was to prepare a plasma stable, pH-sensitive niosomal formulation to enhance Sirolimus efficacy and selectivity. MATERIALS AND METHODS:pH-sensitive niosomal formulations bearing PEG-Poly (monomethyl itaconate)-CholC6 (PEG-PMMI-CholC6) copolymers and cholesteryl hemisu...

journal_title：Pharmaceutical development and technology

authors： Ghanbarzadeh S,Khorrami A,Pourmoazzen Z,Arami S

更新日期：2015-05-01 00:00:00

abstract：:This study investigates the physicochemical properties of glycyl-histidyl-lysine-copper (GHK-Cu) to support the development of a formulation for effective topical delivery. The solubility and distribution coefficients (log D) were investigated using conventional methods and GHK concentrations were quantified with a va...

journal_title：Pharmaceutical development and technology

authors： Badenhorst T,Svirskis D,Wu Z

更新日期：2016-03-01 00:00:00

abstract：:This paper proposes the development of a drug product Manufacturing Classification System (MCS) based on processing route. It summarizes conclusions from a dedicated APS conference and subsequent discussion within APS focus groups and the MCS working party. The MCS is intended as a tool for pharmaceutical scientists t...

journal_title：Pharmaceutical development and technology

authors： Leane M,Pitt K,Reynolds G,Manufacturing Classification System (MCS) Working Group.

更新日期：2015-01-01 00:00:00

abstract：:The key for better antitumor efficacy is to improve the specificity of antitumor drugs for tumor cells and diminish their cytotoxicity to normal tissues. Targeted nanoparticles as antitumor drug delivery system can resolve this problem. In this study, we prepared folate and TAT (arginine-rich cell-penetrating peptide)...

journal_title：Pharmaceutical development and technology

authors： Zhang S,Liu Y,Gan Y,Qiu N,Gu Y,Zhu H

更新日期：2019-02-01 00:00:00

abstract：:This study explored the application of chitosan-alginate (CA) and chitosan-pectin (CP) complex films as drug release regulator for the preparation of multiunit controlled-release diclofenac sodium capsules. Pellets containing drug and microcrystalline cellulose, in a ratio of 3:5, were prepared in a fluidized rotary g...

journal_title：Pharmaceutical development and technology

authors： Mitrevej A,Sinchaipanid N,Rungvejhavuttivittaya Y,Kositchaiyong V

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Oxaliplatin has long been used for the treatment of colorectal cancer via intra-venous infusion. In order to improve patient compliance, a solid dosage form for oral administration of oxaliplatin was prepared as nano-sized particles. METHOD:Nano oxaliplatin was prepared employing Fat Employing Supercritical...

journal_title：Pharmaceutical development and technology

authors： Lee SJ,Kim YH,Lee SH,Hahn M

更新日期：2012-03-01 00:00:00

abstract：:The objective of this study was to develop a floating, pulsatile, multiparticulate drug delivery system intended for chronopharmacotherapy of arthritis. The floating pulsatile drug delivery has the advantage that a drug can be released in the upper gastrointestinal tract after a definite time period of no drug release...

journal_title：Pharmaceutical development and technology

authors： Gaikwad M,Belgamwar VS,Tekade A,Gattani S,Surana S

更新日期：2010-03-01 00:00:00

abstract：:The aim of the present study is to prepare risperidone-loaded poly lactic-co-glycolic acid (PLGA) microspheres within microfluidic system and to achieve a formulation with uniform size and monotonic and reproducible release profile. In comparison to batch method, T-junction and serpentine chips were utilized and optim...

journal_title：Pharmaceutical development and technology

authors： Jafarifar E,Hajialyani M,Akbari M,Rahimi M,Shokoohinia Y,Fattahi A

更新日期：2017-09-01 00:00:00

abstract：CONTEXT:The recent US Food and Drug Administration (FDA) legislation has introduced the evaluation of the Design Space of critical process parameters in manufacturing processes. In freeze-drying, a "formulation" is expected to be robust when minor deviations of the product temperature do not negatively affect the final...

journal_title：Pharmaceutical development and technology

authors： Schneid SC,Stärtzel PM,Lettner P,Gieseler H

更新日期：2011-11-01 00:00:00

abstract：:The aim of this study was to investigate early formulation screening in small scale with a miniaturized fluid bed device. Altogether eight different batches were granulated in a Multipart Microscale Fluid bed Powder processor (MMFP) with constant process conditions using electrostatic atomization. Atomization voltage ...

journal_title：Pharmaceutical development and technology

authors： Kivikero N,Murtomaa M,Antikainen O,Hatara J,Juppo AM,Sandler N

更新日期：2011-08-01 00:00:00

abstract：:A paddle method for measurement of the disintegrating time of orally disintegrating tablets with rizatriptan benzoate as a model drug was evaluated. The paddle method employed a dissolution test assembly with tablets immersed in disintegrating medium through a fastened sinker. Paddle stirring rate, opening of the sink...

journal_title：Pharmaceutical development and technology

authors： Que L,Wu W,Cheng X,Hu T

更新日期：2006-01-01 00:00:00

abstract：:The physical-chemical processing variables affecting particle size following precipitation using the supercritical antisolvent (SAS) method were investigated by varying both the composition of the feed solvent and the structure of the solute, using a series of steroids. The key factor influencing particle size in thes...

journal_title：Pharmaceutical development and technology

authors： Sacha GA,Schmitt WJ,Nail SL

更新日期：2006-01-01 00:00:00

abstract：:The purpose of this study was to assess the usefulness of waxy corn (maize) starch as a cofiller and diluent in pellets produced by aqueous extrusion-spheronization. Waxy corn starch was combined with microcrystalline cellulose (MCC) in the range of 20-50% of the entire composition. Pellets containing ordinary corn st...

journal_title：Pharmaceutical development and technology

authors： Junnila R,Palviainen P,Heinämäki J,Myllärinen P,Forssell P,Yliruusi J

更新日期：2000-01-01 00:00:00

abstract：:A prototype parenteral manufacturing facility based on isolation technology was designed, constructed, and commissioned at Warner-Lambert Co., Morris Plains, NJ, with emphasis on its application to research and development (R&D) settings. The facility contains closed isolators for holding, transferring, and manufactur...

journal_title：Pharmaceutical development and technology

authors： Krishna AK,Lodhi SA,Harris MR

更新日期：2000-01-01 00:00:00

abstract：:ABSTRCT Felodipine has been widely used as a poorly water-soluble model drug for various studies to improve its oral bioavailability and in vivo efficacy. In this study, we developed amorphous solid dispersions (ASDs) via spray drying to enhance the bioavailability of felodipine through using natural zein protein as a...

journal_title：Pharmaceutical development and technology

authors： Zhang H,Liu X,Ma X

更新日期：2020-12-01 00:00:00

abstract：:The hygroscopicity of Brequinar sodium, an organ transplant immunosuppressant, at 75% relative humidity highly depends on the crystal form or crystallinity of the drug substance. Hygroscopicity and ease of water uptake of three lots of Brequinar sodium were investigated. Those lots contained different impurities at le...

journal_title：Pharmaceutical development and technology

authors： Wu LS,Pang J,Hussain MA

更新日期：1996-04-01 00:00:00

abstract：:Drug-excipient compatibility studies lay the foundation for designing a chemically stable formulation for clinical and commercial development. This article describes the investigation of oxidative degradation encountered with compound A (a phenylalanine-drug complex) in a capsule dosage form. Two wet- granulation caps...

journal_title：Pharmaceutical development and technology

authors： Wu Y,Dali M,Gupta A,Raghavan K

更新日期：2009-01-01 00:00:00

abstract：:A comprehensive analytical solution that accounts for many factors and assumptions affecting drug concentration profile in the gastrointestinal tract was presented. A sensitivity analysis approach was utilized in order to investigate the importance of different parameters in the model. The partition coefficient is fou...

journal_title：Pharmaceutical development and technology

authors： Idkaidek NM,Abdel-Jabbar N

更新日期：2001-01-01 00:00:00

abstract：:Flecainide base is pharmaceutically active substance used for production of flecainide acetate which is known in market as Tambacor, Almarytm, Apocard, Ecrinal or Flecaine. It is determined that flecainide base forms four polymorphic forms abbreviated as Ib, IIb, IIIb and IVb. Flecainide base form Ib is thermodynamica...

journal_title：Pharmaceutical development and technology

authors： Veldre K,Eglīte Z,Actiņš A,Zvirgzdiņš A,Rozenberga L,Tamanis E

更新日期：2014-02-01 00:00:00

abstract：:Purpose: Intestinal drug absorption is one of the main factors that govern the fraction of oral dose absorbed (Fa) of drugs. It is reported that oral absorption of bortezomib (BTZ) can be restricted by its low intestinal permeability. In this study, we aimed to evaluate the impact of self-nanoemulsifying drug delivery...

journal_title：Pharmaceutical development and technology

authors： Mahmoudian M,Valizadeh H,Löbenberg R,Zakeri-Milani P

更新日期：2020-03-01 00:00:00

abstract：:Poor solubility and bioavailability of drugs are often affected by its microscopic structural properties. Nitrofurantoin (NF), a Biopharmaceutics Classification System class II item, has a low water solubility with low plasma concentrations. To improve its therapeutic efficacy, formulation strategy of solid dispersion...

journal_title：Pharmaceutical development and technology

authors： Teoh XY,Bt Mahyuddin FN,Ahmad W,Chan SY

更新日期：2020-02-01 00:00:00

abstract：:The physicochemical properties and enzymatic stability of esters of phenylephrone, synthesized on the basis of the chemical delivery system (CDS) concept, were studied as a new class of mydriatic agents. Potentiometrically determined ionization constants (pKa) of the novel compounds were in the range 7.19-7.21. The th...

journal_title：Pharmaceutical development and technology

authors： Goskonda VR,Khan MA,Bodor NS,Reddy IK

更新日期：1999-05-01 00:00:00

abstract：PURPOSE:To investigate the influence of the pH of the dissolution medium on immediate release 850 mg metformin hydrochloride tablets. METHODS:A traditional wet granulation method was used to manufacture metformin hydrochloride tablets with or without a disintegrant. Tablet dissolution was conducted using the USP appar...

journal_title：Pharmaceutical development and technology

authors： Desai D,Wong B,Huang Y,Tang D,Hemenway J,Paruchuri S,Guo H,Hsieh D,Timmins P

更新日期：2015-01-01 00:00:00