Preparation of nanoparticles by solvent displacement using a novel recirculation system.

Abstract:

:Submicron colloidal suspensions of poly(epsilon-caprolactone) (PCL) were prepared by the solvent displacement method, using either the conventional form or a new recirculation device. In the latter case, a process that allows the recirculation of the aqueous phase into a device, providing a continuous flow, is proposed. The influence of the organic solution injection rate and polymer concentration on mean particle size and process yield were studied for both methods. The recirculation rate was also analyzed for the recirculation system. Nanoparticles (NPs) showed mean sizes that ranged from 156 to 381. The smallest particles were obtained when recirculation rate, injection rate and polymer concentration were maximized but at the expense of the yield. The only acceptable yields (83-96%) were obtained at the lowest PCL concentration (2.5% w/v). ANOVA tests (alpha = 0.05) showed that the variables implicated in the recirculation system significantly affected the mean particle size and the process yield. The entrapment efficiencies of NPs prepared by the conventional method were not significantly different (alpha = 0.05) from those obtained by the recirculation system.

journal_name

Pharm Dev Technol

authors

Piñón-Segundo E,Ganem-Quintanar A,Rafael Garibay-Bermúdez J,Juan Escobar-Chávez J,López-Cervantes M,Quintanar-Guerrero D

doi

10.1080/10837450600940824

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

493-501

issue

4

eissn

1083-7450

issn

1097-9867

pii

NG3M800852772710

journal_volume

11

pub_type

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