The impact of solid-state form, water content and surface area of magnesium stearate on lubrication efficiency, tabletability, and dissolution.

abstract：CONTEXT AND OBJECTIVE:The objective of the study was to develop a stable capsule formulation of ziprasidone hydrochloride which can be administered without regards to food intake. MATERIALS AND METHODS:The unstable anhydrous form of ziprasidone hydrochloride was stabilized employing hot-melt extrusion and further opti...

journal_title：Pharmaceutical development and technology

authors： Banerjee S,Shankar KR,Prasad Y R

更新日期：2016-11-01 00:00:00

abstract：:The fluorescence polarization technique was used to measure the microviscosity of a series of phospholipid-based emulsions. Fourteen different oil-in-water emulsions containing 20% medium chain length triglycerides, various concentrations and types of phospholipids, and 2.2% glycerin were prepared by microfluidization...

journal_title：Pharmaceutical development and technology

authors： Zhang X,Kirsch LE

更新日期：2004-01-01 00:00:00

abstract：:Aluminum hydroxide adjuvant was pretreated with six concentrations of potassium dihydrogen phosphate to produce a series of adjuvants with various degrees of phosphate substitution for surface hydroxyl. The adsorption of three phosphorylated proteins (alpha casein, dephosphorylated alpha casein, and ovalbumin) by the ...

journal_title：Pharmaceutical development and technology

authors： Iyer S,HogenEsch H,Hem SL

更新日期：2003-01-01 00:00:00

abstract：:Orally dissolving tablets (ODTs) represent one of the recent advances in drug delivery. The foremost objective of this study was to optimize the utilization of lubricant sodium stearyl fumarate in the preparation of dextromethorphan hydrobromide ODTs with enhanced taste-masking properties. The simple blending of sodiu...

journal_title：Pharmaceutical development and technology

authors： Mahrous GM,Ibrahim MA,Mostafa HF,Elzayat EM

更新日期：2019-07-01 00:00:00

abstract：:This paper proposes the development of a drug product Manufacturing Classification System (MCS) based on processing route. It summarizes conclusions from a dedicated APS conference and subsequent discussion within APS focus groups and the MCS working party. The MCS is intended as a tool for pharmaceutical scientists t...

journal_title：Pharmaceutical development and technology

authors： Leane M,Pitt K,Reynolds G,Manufacturing Classification System (MCS) Working Group.

更新日期：2015-01-01 00:00:00

abstract：:Elderly people, children and patients sometimes have difficulties swallowing tablets. To solve this problem, a novel method of preparing tablets that disintegrate rapidly in the mouth was developed. A tablet with high porosity is required for rapid disintegration, but such a tablet is generally fragile. To make a tabl...

journal_title：Pharmaceutical development and technology

authors： Sugimoto M,Matsubara K,Koida Y,Kobayashi M

更新日期：2001-11-01 00:00:00

abstract：:The main objective of the present study was to improve bioavailability of diltiazem hydrochloride and decrease the frequency of dosage form administration by increasing the encapsulation efficiency of the drug, residence time of the dosage form at the site of absorption and sustained release of the drug from the deliv...

journal_title：Pharmaceutical development and technology

authors： Sultana Y,Mall S,Maurya DP,Kumar D,Das M

更新日期：2009-01-01 00:00:00

abstract：:The dry coating process was evaluated in terms of storage stability investigating drug release and agglomeration tendency of the different coated oral dosage forms; hydroxypropyl methylcellulose acetate succinate (HPMCAS) was used with triethylcitrate (TEC) as plasticizer and acetylated monoglyceride (Myvacet) as wett...

journal_title：Pharmaceutical development and technology

authors： Kablitz CD,Urbanetz NA

更新日期：2009-01-01 00:00:00

abstract：:The aim of this work is to evaluate the feasibility of hydrophilic silica aerogels as drug carriers and to investigate the influence of the aerogels properties on the release rate of poorly water-soluble drugs. Hydrophilic silica aerogels of different densities were loaded with two model drugs, ketoprofen and griseofu...

journal_title：Pharmaceutical development and technology

authors： Smirnova I,Suttiruengwong S,Seiler M,Arlt W

更新日期：2004-11-01 00:00:00

abstract：:In the pharmaceutical industry, chemometrics is rapidly establishing itself as a tool that can be used at every step of product development and beyond: from early development to commercialization. This set of multivariate analysis methods allows the extraction of information contained in large, complex data sets thus ...

journal_title：Pharmaceutical development and technology

authors： Ferreira AP,Tobyn M

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To evaluate four novel metrics that compare dissolution profiles and assess their performance characteristics by comparing dissolution profiles of FAST and SLOW immediate release metoprolol tartrate tablets. METHODS:The four novel metrics (rho, rho m, delta a, and delta s), along with f2, were applied to disso...

journal_title：Pharmaceutical development and technology

authors： Seo PR,Shah VP,Polli JE

更新日期：2002-05-01 00:00:00

abstract：:Controlled release of a marker drug, 4,4'-bis(2-sulfostyryl) biphenyl (DSBP) from genipin crosslinked gelatin thin films, with application to drug delivery by transdermal patches is studied in this paper. A simple method for fabrication of nano-thin films, using basic lab equipment is introduced. This method consists ...

journal_title：Pharmaceutical development and technology

authors： Abbasi A,Eslamian M,Heyd D,Rousseau D

更新日期：2008-01-01 00:00:00

abstract：:Substituting spacer by another in noninvasive ventilation (NIV) involves many variables, e.g. total emitted dose (TED), mass median aerodynamic diameter (MMAD), type of spacer, total lung deposition and total systemic absorption, which must be adjusted to ensure patient optimum therapy. Data mining based on artificial...

journal_title：Pharmaceutical development and technology

authors： Hussein RRS,M A Ali A,Salem HF,Abdelrahman MM,Said ASA,Abdelrahim MEA

更新日期：2017-11-01 00:00:00

abstract：:Mefenamic acid (MA), a poorly water-soluble drug, was used as a model substance to investigate granules and tablet characteristics to be optimized for the loading volume of MA (0-74.1% v/v) in the formulation including lactose monohydrate/maize starch (7/3) as excipients. The compactibility of granules increased with ...

journal_title：Pharmaceutical development and technology

authors： Kimura G,Betz G,Leuenberger H

更新日期：2008-01-01 00:00:00

abstract：:This paper assesses the cause of particulate formation in vials of the experimental antitumor agent bisnafide and investigates pharmaceutical techniques to reduce the number of particulates in the product. Solution preparation and particulate isolation were performed under Class 100 laminar air flow. Reversed-phase HP...

journal_title：Pharmaceutical development and technology

authors： Rubino JT,Chan LL,Walker JT,Segretario J,Everlof JG,Hussain MA

更新日期：1999-08-01 00:00:00

abstract：:The purpose of this study was to develop a method to prepare Metoprolol Succinate (MS) sustained release pellets and compress them into pellet-containing tablets without losing sustained release property. The drug layered pellets were coated with Eudragit NE 30D to obtain a sustained release (SR) property. The mechani...

journal_title：Pharmaceutical development and technology

authors： Yang Z,Yu J,Yang T,Xing H,Zhang J,Xian L,Ding P,Wang D

更新日期：2016-12-01 00:00:00

abstract：:An approach for cancer treatment is modulation of tumor microenvironment. Based on the role of extracellular matrix in cell modulation, fabrication of textured materials mimicking extracellular matrix could provide novel opportunities such as determining cancer cell behaviour. With this background, in this work, we ha...

journal_title：Pharmaceutical development and technology

authors： Yaşayan G,Mega Tiber P,Orun O,Alarçin E

更新日期：2020-12-01 00:00:00

abstract：:Nucleic acids therapeutic efficiency is generally limited by their low stability and intracellular bioavailability, and by the toxicity of the carriers used to deliver them to the target sites. Aminated poly(glycerol methacrylate) polymers are biodegradable and pH-sensitive polymers that have been used previously to d...

journal_title：Pharmaceutical development and technology

authors： Morsi NG,Ali SM,Elsonbaty SS,Afifi AA,Hamad MA,Gao H,Elsabahy M

更新日期：2018-04-01 00:00:00

abstract：:Poor solubility and bioavailability of drugs are often affected by its microscopic structural properties. Nitrofurantoin (NF), a Biopharmaceutics Classification System class II item, has a low water solubility with low plasma concentrations. To improve its therapeutic efficacy, formulation strategy of solid dispersion...

journal_title：Pharmaceutical development and technology

authors： Teoh XY,Bt Mahyuddin FN,Ahmad W,Chan SY

更新日期：2020-02-01 00:00:00

abstract：:The aim of this study was to investigate early formulation screening in small scale with a miniaturized fluid bed device. Altogether eight different batches were granulated in a Multipart Microscale Fluid bed Powder processor (MMFP) with constant process conditions using electrostatic atomization. Atomization voltage ...

journal_title：Pharmaceutical development and technology

authors： Kivikero N,Murtomaa M,Antikainen O,Hatara J,Juppo AM,Sandler N

更新日期：2011-08-01 00:00:00

abstract：:Background: Clindamycin's bitter taste and odor is known to affect treatment adherence in children. Recently, a formulation of clindamycin HCl complexed with ion exchange resin IRP 69 was shown to mask the bitter taste. Because of the potential benefit of this formulation for children, a pilot study using a porcine mo...

journal_title：Pharmaceutical development and technology

authors： Goode GA,Wagh SJ,Irby DJ,Ma D,Jacobs RF,Kearns GL,Almoazen H

更新日期：2019-10-01 00:00:00

abstract：:Two polymorphs and three solvates of fluconazole were isolated and characterized by x-ray powder diffractometry, IR spectroscopy, differential scanning calorimetry (DSC), thermogravimetry, and their dissolution rates. The different forms were prepared by crystallization of the original powder in different solvents at ...

journal_title：Pharmaceutical development and technology

authors： Alkhamis KA,Obaidat AA,Nuseirat AF

更新日期：2002-11-01 00:00:00

abstract：:The purpose of this study was to improve the sensitivity and accuracy of quantitative analysis of polymorphic mixtures. Various techniques such as hand grinding and mixing (in mortar and pestle), air jet milling and ball milling for micronization of particle and mixing were used to prepare binary mixtures. Using these...

journal_title：Pharmaceutical development and technology

authors： Alam S,Patel S,Bansal AK

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:Aerodynamically stable, nebulized aerosols are desirable to achieve optimum asthma therapy. Stabilizing droplet size using gel-forming polymers may assist in achieving this goal. Semisolid particles may be generated through aerosolization of a polymer solution. Gelatin was employed as a model polymer in a proce...

journal_title：Pharmaceutical development and technology

authors： Deaton AT,Jones LD,Dunbar CA,Hickey AJ,Williams DM

更新日期：2002-05-01 00:00:00

abstract：:Pharmaceutical aerosols have the potential to prevent pulmonary infectious diseases. Liposomal amphotericin B (LAMB, Ambisome, Astellas Pharma US, Deerfield, IL, USA) is approved as an intravenous infusion for empiric treatment of presumed fungal infections in neutropenic, febrile patients, as well as patients infecte...

journal_title：Pharmaceutical development and technology

authors： Alexander BD,Winkler TP,Shi S,Dodds Ashley ES,Hickey AJ

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:The purpose of the present investigation was to prepare a plasma stable, pH-sensitive niosomal formulation to enhance Sirolimus efficacy and selectivity. MATERIALS AND METHODS:pH-sensitive niosomal formulations bearing PEG-Poly (monomethyl itaconate)-CholC6 (PEG-PMMI-CholC6) copolymers and cholesteryl hemisu...

journal_title：Pharmaceutical development and technology

authors： Ghanbarzadeh S,Khorrami A,Pourmoazzen Z,Arami S

更新日期：2015-05-01 00:00:00

abstract：:Photon correlation spectroscopy (PCS) is compared with classic rheological measurements using the cone-and-plate technique for the determination of the viscosity of protein solutions. The potential advantages using PCS are small sample volume and fast determination of zero-shear viscosity. The present study assesses p...

journal_title：Pharmaceutical development and technology

authors： Wagner M,Reiche K,Blume A,Garidel P

更新日期：2013-07-01 00:00:00

abstract：:The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. Fluvastatin (FLV) samples were characterized by several techniqu...

journal_title：Pharmaceutical development and technology

authors： Borgmann SH,Bernardi LS,Rauber GS,Oliveira PR,Campos CE,Monti G,Cuffini SL,Cardoso SG

更新日期：2013-03-01 00:00:00

abstract：CONTEXT:Bioadhesiviness of polyacrylic acid polymers make them promising hydrogels to design topical drug delivery systems, allowing a close contact with biological substrate as well as an enhanced local concentration gradient, both factors that may improve the biological performance of the drugs. AIM:Texture and bioa...

journal_title：Pharmaceutical development and technology

authors： Calixto G,Yoshii AC,Rocha e Silva H,Stringhetti Ferreira Cury B,Chorilli M

更新日期：2015-06-01 00:00:00

abstract：:Oily liquid drugs are not convenient for oral administration. We developed a powder containing clofibrate (CF), a model of an oily drug, using aminoalkyl methacrylate copolymer (EPO) or methacrylic acid copolymer (L100). CF or a mixture of CF and soybean oil was emulsified with EPO or L100 aqueous solution. Using a hi...

journal_title：Pharmaceutical development and technology

authors： Fujii M,Kawakami A,Saito A,Tuchiya H,Koizumi N,Watanabe Y

更新日期：2016-12-01 00:00:00