Chemical delivery systems: evaluation of physicochemical properties and enzymatic stability of phenylephrone derivatives.

abstract：PURPOSE:BMS-196843 (Oncostatin M) is a therapeutic recombinant protein in development. Scale-up process changes led to unexpected instability of the bulk drug substance solution during storage. A product with an apparent higher MW than the parent protein was observed by the size-exclusion chromatography (SEC). This stu...

journal_title：Pharmaceutical development and technology

authors： Zhao F,Stein DJ,Paborji M,Cash PW,Root BJ,Wei Z,Knupp CJ

更新日期：2001-01-01 00:00:00

abstract：:ABSTRCT Felodipine has been widely used as a poorly water-soluble model drug for various studies to improve its oral bioavailability and in vivo efficacy. In this study, we developed amorphous solid dispersions (ASDs) via spray drying to enhance the bioavailability of felodipine through using natural zein protein as a...

journal_title：Pharmaceutical development and technology

authors： Zhang H,Liu X,Ma X

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:Teicoplanin is a glycopeptide antibiotic consisting of a combination of different active components. Clinical equivalence between different batches of this drug is not guaranteed by the present pharmacopeial specification of chemical composition based on an HPLC chromatogram. OBJECTIVE:To test a modification o...

journal_title：Pharmaceutical development and technology

authors： Boix-Montañes A,Garcia-Arieta A

更新日期：2016-08-01 00:00:00

abstract：:The aim of this study was to investigate isotropic mono- and diglyceride-based (MCMDG) systems, which are potential vehicles for injectable products containing both hydrophilic and lipophilic drugs. For two-component systems, MCMDG was mixed with various masses of water. For three-component systems, the samples were p...

journal_title：Pharmaceutical development and technology

authors： Sari P,Razzak M,Tucker IG

更新日期：2004-01-01 00:00:00

abstract：:In pediatrics, it is crucial to ameliorate the unpleasant taste of oral pharmaceutical formulations in order to facilitate patient compliance. Scientists' attempt to develop modern products for children is included among the new trends in pharmaceutical technology. Designing the preparation procedures and selecting th...

journal_title：Pharmaceutical development and technology

authors： Karaiskou SG,Kouskoura MG,Markopoulou CK

更新日期：2020-01-01 00:00:00

abstract：:The main purpose of this work was to develop a supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) of carbamazepine (CBZ). S-SMEDDS of CBZ was prepared and drug precipitation behavior, dissolution rate in vitro and particle size distribution were evaluated. The relative bioavailability of S-SMEDDS f...

journal_title：Pharmaceutical development and technology

authors： Zhang N,Zhang W,Jin Y,Quan DQ

更新日期：2011-08-01 00:00:00

abstract：:The purpose of this research was to design and develop a novel controlled-release bead formulation for oral administration with buffer crystals as a carrier for loading of fenoldopam mesylate, an intravenous antihypertensive agent, which provides an in vitro release rate of 30-50 mg/hr for 6-8 hr. Buffer crystals were...

journal_title：Pharmaceutical development and technology

authors： Venkatesh GM

更新日期：1998-11-01 00:00:00

abstract：:It is well known that carriers can affect the dissolution of poorly soluble drugs. In this study, our aim was to investigate the dissolution enhancement of carbamazepine solid dispersed or mixed at different loading ratios in crospovidone, polyvinylpyrrolidone, and sodium starch glycolate. The physical state of the dr...

journal_title：Pharmaceutical development and technology

authors： Moneghini M,Voinovich D,Perissutti B,Princivalle F

更新日期：2002-01-01 00:00:00

abstract：:The effect of some processing and formulation variables on the stability of tablets containing a crystalline salt of a triazine derivative was studied. The salt has a relatively low melting point and a low microenvironmental pH due to the weakly basic nature of the parent compound (pKa = 4.0). This compound decomposes...

journal_title：Pharmaceutical development and technology

authors： Badawy S,Vickery R,Shah K,Hussain M

更新日期：2004-08-01 00:00:00

abstract：:The purpose of this paper was to investigate the effect of several experimental variables on the ability of a neural network to predict in vitro dissolution rate as a function of product formulation changes. Neural network software was trained with sets of hypothetical and experimental data consisting of 4-15 formulat...

journal_title：Pharmaceutical development and technology

authors： Ebube NK,McCall T,Chen Y,Meyer MC

更新日期：1997-08-01 00:00:00

abstract：:The contact time of a vehicle on the cornea is of utmost importance for ophthalmic drug delivery. The poor bioavailability and therefore poor therapeutic response exhibited by the conventional ophthalmic solutions due to pre-corneal elimination of a drug may be overcome by the use of the in situ gel forming systems, w...

journal_title：Pharmaceutical development and technology

authors： Gupta S,Samanta MK

更新日期：2010-07-01 00:00:00

abstract：:The present study was carried out in order to mask the bitter taste of the Etoricoxib by complexation with cation-exchange resin, Indion 204. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 mi...

journal_title：Pharmaceutical development and technology

authors： Patra S,Samantaray R,Pattnaik S,Barik BB

更新日期：2010-09-01 00:00:00

abstract：:To develop an effective therapeutic treatment, the potential of poly (lactic-co-glycolic acid)-polyethylene glycol-retinoic acid (PLGA-PEG-RA) polymeric micelles for targeted delivery of irinotecan to hepatocellular carcinoma (HepG2) and colorectal cancer cell lines (HT-29) was evaluated. PLGA-PEG-RA was synthesized b...

journal_title：Pharmaceutical development and technology

authors： Emami J,Maghzi P,Hasanzadeh F,Sadeghi H,Mirian M,Rostami M

更新日期：2018-01-01 00:00:00

abstract：:New microspheres containing hydrophilic core and hydrophobic coating as a controlled-release system with no toxic reagents were proposed. Water in oil in water (W/O/W) emulsion and solvent evaporation methods were used to make chitosan/ cellulose acetate (CCA) microspheres sized 200 - 400 microm. Ranitidine hydrochlor...

journal_title：Pharmaceutical development and technology

authors： Zhou HY,Chen XG,Liu CS,Meng XH,Yu LJ,Liu XY,Liu N

更新日期：2005-01-01 00:00:00

abstract：:The taste of oral dosage forms is an important argument regarding patient's compliance and acceptability. For this reason, it is often necessary to mask an undesirable and unpleasant taste of an active pharmaceutical ingredient. The purpose of this study was to mask the taste of naproxen sodium by a new fluid-bed coat...

journal_title：Pharmaceutical development and technology

authors： Stange U,Führling C,Gieseler H

更新日期：2014-03-01 00:00:00

abstract：:Photon correlation spectroscopy (PCS) is compared with classic rheological measurements using the cone-and-plate technique for the determination of the viscosity of protein solutions. The potential advantages using PCS are small sample volume and fast determination of zero-shear viscosity. The present study assesses p...

journal_title：Pharmaceutical development and technology

authors： Wagner M,Reiche K,Blume A,Garidel P

更新日期：2013-07-01 00:00:00

abstract：:In the present study, Simvastatin was incorporated in emulsion of soybean oil and propylene glycol monocaprylate as oily phase and Tween 80 and Cremophor EL as surfactants and also their mixtures. Dry adsorbed emulsions were prepared by using colloidal silicon dioxide in varying proportions to adsorb the liquid emulsi...

journal_title：Pharmaceutical development and technology

authors： Dixit RP,Nagarsenker MS

更新日期：2007-01-01 00:00:00

abstract：:The present work investigated the magnitude of microsphere-induced acute myotoxicity and determined whether this myotoxicity is related to microsphere size and/or reconstitution solvent. Using a high molecular weight poly(dl-lactide-co-glycolide) copolymer, the myotoxicity of two different size microsphere formulation...

journal_title：Pharmaceutical development and technology

authors： Brazeau GA,Sciame M,al-Suwayeh SA,Fattal E

更新日期：1996-10-01 00:00:00

abstract：:Clinical trials of cholesterol ester transfer protein (CETP) peptide vaccine were stopped after disappointing results in humans due to the inadequacy of adjuvant aluminum hydroxide in stimulating the immune response against the self-antigen of CETP. To increase the efficacy of the CETP vaccine, we developed a novel li...

journal_title：Pharmaceutical development and technology

authors： Aghebati T,Arabsalmani M,Mohammadpour AH,Afshar M,Jaafari MR,Abnous K,Nazemi S,Badiee A

更新日期：2020-04-01 00:00:00

abstract：:This paper proposes the development of a drug product Manufacturing Classification System (MCS) based on processing route. It summarizes conclusions from a dedicated APS conference and subsequent discussion within APS focus groups and the MCS working party. The MCS is intended as a tool for pharmaceutical scientists t...

journal_title：Pharmaceutical development and technology

authors： Leane M,Pitt K,Reynolds G,Manufacturing Classification System (MCS) Working Group.

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To investigate the influence of the pH of the dissolution medium on immediate release 850 mg metformin hydrochloride tablets. METHODS:A traditional wet granulation method was used to manufacture metformin hydrochloride tablets with or without a disintegrant. Tablet dissolution was conducted using the USP appar...

journal_title：Pharmaceutical development and technology

authors： Desai D,Wong B,Huang Y,Tang D,Hemenway J,Paruchuri S,Guo H,Hsieh D,Timmins P

更新日期：2015-01-01 00:00:00

abstract：:Mucosa has now been recognized as a potential site for both local and systemic delivery of therapeutics. Mucoadhesive drug delivery systems with customizable release profiles have recently gained considerable interest among formulation scientists to improve clinical outcomes of drugs. This review summarizes the curren...

journal_title：Pharmaceutical development and technology

authors： Kumar A,Naik PK,Pradhan D,Ghosh G,Rath G

更新日期：2020-09-01 00:00:00

abstract：:Co-solvent solubilization approach has been used to enhance the solubility of seven antidiabetic drugs: gliclazide, glyburide, glipizide, glimepiride, repaglinide, pioglitazone, and roziglitazone. Solubility in water, phosphate buffer (pH 7.4), six co-solvent solutions prepared in water as well as phosphate buffer (pH...

journal_title：Pharmaceutical development and technology

authors： Seedher N,Kanojia M

更新日期：2009-01-01 00:00:00

abstract：:Aluminum hydroxide adjuvant was pretreated with six concentrations of potassium dihydrogen phosphate to produce a series of adjuvants with various degrees of phosphate substitution for surface hydroxyl. The adsorption of three phosphorylated proteins (alpha casein, dephosphorylated alpha casein, and ovalbumin) by the ...

journal_title：Pharmaceutical development and technology

authors： Iyer S,HogenEsch H,Hem SL

更新日期：2003-01-01 00:00:00

abstract：:The main objective of the present study was to improve bioavailability of diltiazem hydrochloride and decrease the frequency of dosage form administration by increasing the encapsulation efficiency of the drug, residence time of the dosage form at the site of absorption and sustained release of the drug from the deliv...

journal_title：Pharmaceutical development and technology

authors： Sultana Y,Mall S,Maurya DP,Kumar D,Das M

更新日期：2009-01-01 00:00:00

abstract：:The objective of the study was to develop a mathematical model for predicting the disintegration time of fast disintegrating tablets (FDTs) by estimating the powder characteristics of powder blend prior to compression. A combination of chitosan-alginate complex and glycine in the ratio of 50:50 was used for preparing ...

journal_title：Pharmaceutical development and technology

authors： Goel H,Arora A,Tiwary AK,Rana V

更新日期：2011-02-01 00:00:00

abstract：:The objective of this study was to develop and evaluate a novel microemulsion based gel formulation containing tazarotene for targeted topical therapy of acne. Psudoternary phase diagrams were constructed to obtain the concentration range of oil, surfactant, and co-surfactant for microemulsion formation. The optimized...

journal_title：Pharmaceutical development and technology

authors： Patel MR,Patel RB,Parikh JR,Patel BG

更新日期：2016-12-01 00:00:00

abstract：:A comprehensive analytical solution that accounts for many factors and assumptions affecting drug concentration profile in the gastrointestinal tract was presented. A sensitivity analysis approach was utilized in order to investigate the importance of different parameters in the model. The partition coefficient is fou...

journal_title：Pharmaceutical development and technology

authors： Idkaidek NM,Abdel-Jabbar N

更新日期：2001-01-01 00:00:00

abstract：:A high-pressure homogenization method for the production of aqueous suspensions of poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) was investigated. Depending on the production conditions it was possible to produce micro--as well as nanoparticulate systems without the use of organic solvents. The influence of dif...

journal_title：Pharmaceutical development and technology

authors： Calvör A,Müller BW

更新日期：1998-08-01 00:00:00

abstract：:The aim of this work is development of a nontoxic, long-term stable solid lipid nanoparticles (SLN) formulation for the loading of Nimesulide (NiM) by a 22 factorial design. The optimized formulation was composed of 10 wt% of glyceryl behenate and 2.5 wt% of poloxamer 188. Immediately after production, Z-Ave of NiM-SL...

journal_title：Pharmaceutical development and technology

authors： Campos JR,Fernandes AR,Sousa R,Fangueiro JF,Boonme P,Garcia ML,Silva AM,Naveros BC,Souto EB

更新日期：2019-06-01 00:00:00