Mucoadhesive formulations: innovations, merits, drawbacks, and future outlook.

abstract：:Alendronate sodium (ALD) is a bisphosphonate medication used in the treatment and prevention of osteoporosis. Absorption of ALD as oral formulation is very poor (0.5%-1%). Its bioavailability can decrease with food effect. It has some gastrointestinal adverse effects such as gastritis, gastric ulcer, and esophagitis. ...

journal_title：Pharmaceutical development and technology

authors： Asikoğlu M,Ozguney I,Ozcan I,Orumlu O,Guneri T,Koseoğlu K,Ozkilic H

更新日期：2008-01-01 00:00:00

abstract：:The objective of this study was to develop and evaluate a novel microemulsion based gel formulation containing tazarotene for targeted topical therapy of acne. Psudoternary phase diagrams were constructed to obtain the concentration range of oil, surfactant, and co-surfactant for microemulsion formation. The optimized...

journal_title：Pharmaceutical development and technology

authors： Patel MR,Patel RB,Parikh JR,Patel BG

更新日期：2016-12-01 00:00:00

abstract：:A novel analytical procedure has been developed for quantitative determination of levodopa and carbidopa in aqueous binary solutions acidified by HCl and without any other sample pretreatment. The method is based partially on least squares treatment of data obtained by attenuated total reflectance Fourier transform in...

journal_title：Pharmaceutical development and technology

authors： Khanmohammadi M,Mobedi E,Garmarudi AB,Mobedi H,Kargosha K

更新日期：2007-01-01 00:00:00

abstract：:The present study was aimed to develop a matrix-type transdermal formulation of pentazocine using mixed polymeric grades of Eudragit RL/RS. The possible interaction between drug and polymer used were characterized by FTIR, DSC and X-RD. X-RD study indicates a change of state of drug from crystalline to amorphous in th...

journal_title：Pharmaceutical development and technology

authors： Chandak AR,Prasad Verma PR

更新日期：2010-06-01 00:00:00

abstract：:The purpose of this study was to improve the sensitivity and accuracy of quantitative analysis of polymorphic mixtures. Various techniques such as hand grinding and mixing (in mortar and pestle), air jet milling and ball milling for micronization of particle and mixing were used to prepare binary mixtures. Using these...

journal_title：Pharmaceutical development and technology

authors： Alam S,Patel S,Bansal AK

更新日期：2010-09-01 00:00:00

abstract：:Mechanically generated radicals were shown to affect short-term stability of a model pharmaceutical formulation during high-shear processing. A formulation containing an oxidatively sensitive drug, either amorphous or crystalline, and a polymeric excipient was high-shear mixed and the resulting short-term degradation ...

journal_title：Pharmaceutical development and technology

authors： Polizzi MA,Singhal D,Colvin J

更新日期：2008-01-01 00:00:00

abstract：:In pediatrics, it is crucial to ameliorate the unpleasant taste of oral pharmaceutical formulations in order to facilitate patient compliance. Scientists' attempt to develop modern products for children is included among the new trends in pharmaceutical technology. Designing the preparation procedures and selecting th...

journal_title：Pharmaceutical development and technology

authors： Karaiskou SG,Kouskoura MG,Markopoulou CK

更新日期：2020-01-01 00:00:00

abstract：:A carbopol 934P-based drug delivery system (AmDDS) was developed to achieve the dual-controlled delivery of Nonoxynol-9 (N-9), a spermicidal agent, and EDTA, a potentiator of spermicidal activity. This gel-type system made intimate contact with vaginal mucosa and maintained an effective drug concentration within the v...

journal_title：Pharmaceutical development and technology

authors： Lee CH,Chien YW

更新日期：1996-07-01 00:00:00

abstract：:The key for better antitumor efficacy is to improve the specificity of antitumor drugs for tumor cells and diminish their cytotoxicity to normal tissues. Targeted nanoparticles as antitumor drug delivery system can resolve this problem. In this study, we prepared folate and TAT (arginine-rich cell-penetrating peptide)...

journal_title：Pharmaceutical development and technology

authors： Zhang S,Liu Y,Gan Y,Qiu N,Gu Y,Zhu H

更新日期：2019-02-01 00:00:00

abstract：CONTEXT:Teicoplanin is a glycopeptide antibiotic consisting of a combination of different active components. Clinical equivalence between different batches of this drug is not guaranteed by the present pharmacopeial specification of chemical composition based on an HPLC chromatogram. OBJECTIVE:To test a modification o...

journal_title：Pharmaceutical development and technology

authors： Boix-Montañes A,Garcia-Arieta A

更新日期：2016-08-01 00:00:00

abstract：:Hypericin (Hyp), a natural hydrophobic and photoactive pigment, and methylene blue (MB), a hydrophilic cationic dye, are utilized as photosensitizer (PS) for photodynamic therapy of cancer. Bioadhesive and thermoresponsive polymeric systems can improve the drug availability by increasing the contact time between the s...

journal_title：Pharmaceutical development and technology

authors： Borghi-Pangoni FB,Junqueira MV,Bruschi ML

更新日期：2020-04-01 00:00:00

abstract：:The aim of this study was to investigate early formulation screening in small scale with a miniaturized fluid bed device. Altogether eight different batches were granulated in a Multipart Microscale Fluid bed Powder processor (MMFP) with constant process conditions using electrostatic atomization. Atomization voltage ...

journal_title：Pharmaceutical development and technology

authors： Kivikero N,Murtomaa M,Antikainen O,Hatara J,Juppo AM,Sandler N

更新日期：2011-08-01 00:00:00

abstract：:The present study was aimed to optimize capsulated unfolding type gastroretentive bilayer film constituting immediate release (IR) layer of amlodipine besylate and sustained release (SR) layer of atorvastatin calcium. A three-factor, three-level Box-Behnken-design was used to optimize bilayer film with dual-release ch...

journal_title：Pharmaceutical development and technology

authors： Porwal A,Dwivedi H,Pathak K

更新日期：2020-04-01 00:00:00

abstract：:The objective of this paper was to evaluate the mucoadhesive and sustained-release properties of the water-soluble gum obtained from Hakea gibbosa (hakea), for the formulation of buccal tablets. Flatfaced tablets containing hakea were formulated using chlorpheniramine maleate (CPM) as a model drug. Two types of tablet...

journal_title：Pharmaceutical development and technology

authors： Alur HH,Pather SI,Mitra AK,Johnston TP

更新日期：1999-08-01 00:00:00

abstract：:This study examines the effect of the degree of methoxylation (DM) and particle size on compression properties and compactibility of pectin powders. A powder classification system based on sequential handling of compression parameters was applied. A single size fraction (90-125 μm) of pectin powders with DM values ran...

journal_title：Pharmaceutical development and technology

authors： Salbu L,Bauer-Brandl A,Alderborn G,Tho I

更新日期：2012-05-01 00:00:00

abstract：:The objective of the present investigation was to formulate and evaluate orodispersible tablets (ODTs) of ondansetron HCl possessing sufficient mechanical strength by wet granulation or direct compression method. A combination of glycine and chitosan was employed for providing a sweet tasting disintegrating system. Th...

journal_title：Pharmaceutical development and technology

authors： Goel H,Vora N,Tiwary AK,Rana V

更新日期：2009-01-01 00:00:00

abstract：:The high initial burst release of a highly water-soluble drug from poly (D,L-lactide-co-glycolide) (PLGA) microparticles prepared by the multiple emulsion (w/o/w) solvent extraction/evaporation method was reduced by coating with an additional polymeric PLGA layer. Coating with high encapsulation efficiency was perform...

journal_title：Pharmaceutical development and technology

authors： Ahmed AR,Elkharraz K,Irfan M,Bodmeier R

更新日期：2012-01-01 00:00:00

abstract：CONTEXT:Skin delivery of Meloxicam (MX) offers several advantages over the oral route which is associated with potential side effects. OBJECTIVES:The aim of this study was to develop transdermal MX in niosomes. MATERIALS AND METHODS:Vesicles prepared by thin film hydration method were characterized and the acute anti...

journal_title：Pharmaceutical development and technology

authors： El-Menshawe SF,Hussein AK

更新日期：2013-07-01 00:00:00

abstract：:The aim of this research was to develop and assess a new dissolution apparatus for orodispersible films (ODFs). The new apparatus was based on a flow-through cell design which requires only a limited amount of dissolution medium and can automatically collect samples in short-time intervals. Compared with the dissoluti...

journal_title：Pharmaceutical development and technology

authors： Xia Y,Chen F,Zhang H,Luo C

更新日期：2015-05-01 00:00:00

abstract：CONTEXT:Development and evaluation of thermosensitive and bioadhesive liquid suppositories containing ketoprofen (KP). OBJECTIVE:This study was conducted to develope thermosensitive and bioadhesive liquid suppositories containing KP using poloxamer and different bioadhesive polymers and to investigate their gelation t...

journal_title：Pharmaceutical development and technology

authors： Ozgüney I,Kardhiqi A

更新日期：2014-12-01 00:00:00

abstract：:The main objective of the present study was to improve bioavailability of diltiazem hydrochloride and decrease the frequency of dosage form administration by increasing the encapsulation efficiency of the drug, residence time of the dosage form at the site of absorption and sustained release of the drug from the deliv...

journal_title：Pharmaceutical development and technology

authors： Sultana Y,Mall S,Maurya DP,Kumar D,Das M

更新日期：2009-01-01 00:00:00

abstract：:The physical stability of amorphous solid dispersions (SDs) is influenced by their storage conditions. The goal of this work was to investigate the factors affecting the recrystallization of drugs in SDs after storage under conditions of high temperature and high humidity. SDs of three drugs (dipyridamole, nifedipine ...

journal_title：Pharmaceutical development and technology

authors： Shibata Y,Fujii M,Suzuki A,Koizumi N,Kanada K,Yamada M,Watanabe Y

更新日期：2014-06-01 00:00:00

abstract：:The principal purpose of the present study was to prepare and characterize a complex drug delivery system consisting of Nafarelin-poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) in combination with sodium alginate/poloxamer 407 in situ gel. Nafarelin-loaded PHBV NPs were prepared via double em...

journal_title：Pharmaceutical development and technology

authors： Alizadeh B,Bahari Javan N,Akbari Javar H,Khoshayand MR,Dorkoosh F

更新日期：2018-02-01 00:00:00

abstract：:The fluorescence polarization technique was used to measure the microviscosity of a series of phospholipid-based emulsions. Fourteen different oil-in-water emulsions containing 20% medium chain length triglycerides, various concentrations and types of phospholipids, and 2.2% glycerin were prepared by microfluidization...

journal_title：Pharmaceutical development and technology

authors： Zhang X,Kirsch LE

更新日期：2004-01-01 00:00:00

abstract：:Dual drug nanocrystals loaded nano embedded microparticles (DNEMs) were prepared for fixed dose combination of simvastatin (SIM) and ezetimibe (EZE) using NanoCrySP technology. The purpose was to generate nanonized SIM and EZE dispersed in matrix of single crystallization inducing excipient and investigate their in vi...

journal_title：Pharmaceutical development and technology

authors： Nandi S,Kaur A,Bansal AK

更新日期：2020-01-01 00:00:00

abstract：:The taste of oral dosage forms is an important argument regarding patient's compliance and acceptability. For this reason, it is often necessary to mask an undesirable and unpleasant taste of an active pharmaceutical ingredient. The purpose of this study was to mask the taste of naproxen sodium by a new fluid-bed coat...

journal_title：Pharmaceutical development and technology

authors： Stange U,Führling C,Gieseler H

更新日期：2014-03-01 00:00:00

abstract：:In recent years, drug delivery systems such as liposomes and microparticles have been used in clinic for the treatment of different diseases and from a regulatory point of view, a parenterally applied drug and drug delivery systems must be sterile and pyrogen free. Radiation sterilization is a method recognized by pha...

journal_title：Pharmaceutical development and technology

authors： Sakar F,Özer AY,Erdogan S,Ekizoglu M,Kart D,Özalp M,Colak S,Zencir Y

更新日期：2017-09-01 00:00:00

abstract：:To develop an effective therapeutic treatment, the potential of poly (lactic-co-glycolic acid)-polyethylene glycol-retinoic acid (PLGA-PEG-RA) polymeric micelles for targeted delivery of irinotecan to hepatocellular carcinoma (HepG2) and colorectal cancer cell lines (HT-29) was evaluated. PLGA-PEG-RA was synthesized b...

journal_title：Pharmaceutical development and technology

authors： Emami J,Maghzi P,Hasanzadeh F,Sadeghi H,Mirian M,Rostami M

更新日期：2018-01-01 00:00:00

abstract：:Bupivacaine lipid microparticles were prepared and evaluated as a parenteral sustained-release dosage form for postoperative pain management. Bupivacaine free base was incorporated into a molten tristearin matrix and lipid micro-particles were subsequently formed from this molten mixture by a spray-congealing process....

journal_title：Pharmaceutical development and technology

authors： Li LC,Zhu L,Song JF,Deng JS,Bandopadhyay R,Wurster DE

更新日期：2005-01-01 00:00:00

abstract：:The present study details the development of a small-scale spray-drying approach for the routine screening of amorphous solid dispersions (ASDs). This strategy aims to overcome the limitations of standard screening methodologies like solvent casting and quench cooling to predict drug-polymer miscibility of spray-dried...

journal_title：Pharmaceutical development and technology

authors： Ousset A,Bassand C,Chavez PF,Meeus J,Robin F,Schubert MA,Somville P,Dodou K

更新日期：2019-06-01 00:00:00