Taste masking of Etoricoxib by using ion-exchange resin.

abstract：:The taste of oral dosage forms is an important argument regarding patient's compliance and acceptability. For this reason, it is often necessary to mask an undesirable and unpleasant taste of an active pharmaceutical ingredient. The purpose of this study was to mask the taste of naproxen sodium by a new fluid-bed coat...

journal_title：Pharmaceutical development and technology

authors： Stange U,Führling C,Gieseler H

更新日期：2014-03-01 00:00:00

abstract：:The aim of this study was to develop and characterize nanocrystal formulation containing nimesulide. Physical mixture of drug and excipient (nimesulide:pluronic F127, 1:0.5) was also prepared to compare the efficiency of formulations. The physicochemical characteristics of the formulations were determined by means of ...

journal_title：Pharmaceutical development and technology

authors： Gülsün T,Budak C,Vural I,Sahin S,Öner L

更新日期：2013-05-01 00:00:00

abstract：:This study investigates the physicochemical properties of glycyl-histidyl-lysine-copper (GHK-Cu) to support the development of a formulation for effective topical delivery. The solubility and distribution coefficients (log D) were investigated using conventional methods and GHK concentrations were quantified with a va...

journal_title：Pharmaceutical development and technology

authors： Badenhorst T,Svirskis D,Wu Z

更新日期：2016-03-01 00:00:00

abstract：:The investigation was aimed at developing thermodynamically stable topical delivery system of nanostructured lipid carrier of econazole nitrate (EN) for the treatment of deep seated fungal infection by improving its permeability. Fifteen formulations (F1-F15) of nanostructured lipid carriers (NLCs) were prepared by so...

journal_title：Pharmaceutical development and technology

authors： Keshri L,Pathak K

更新日期：2013-05-01 00:00:00

abstract：:New microspheres containing hydrophilic core and hydrophobic coating as a controlled-release system with no toxic reagents were proposed. Water in oil in water (W/O/W) emulsion and solvent evaporation methods were used to make chitosan/ cellulose acetate (CCA) microspheres sized 200 - 400 microm. Ranitidine hydrochlor...

journal_title：Pharmaceutical development and technology

authors： Zhou HY,Chen XG,Liu CS,Meng XH,Yu LJ,Liu XY,Liu N

更新日期：2005-01-01 00:00:00

abstract：:The main purpose of this work was to develop a supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) of carbamazepine (CBZ). S-SMEDDS of CBZ was prepared and drug precipitation behavior, dissolution rate in vitro and particle size distribution were evaluated. The relative bioavailability of S-SMEDDS f...

journal_title：Pharmaceutical development and technology

authors： Zhang N,Zhang W,Jin Y,Quan DQ

更新日期：2011-08-01 00:00:00

abstract：:Transdermal drug administration has a number of advantages that cannot be leveraged for therapeutic benefits because of the robust barrier provided by the stratum corneum. One of the promising techniques for circumventing the stratum corneum is sonophoresis - the use of ultrasound for facilitating transdermal drug del...

journal_title：Pharmaceutical development and technology

authors： Ita K

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present work was the development of vaginal sponge-like dressings based on chitosan ascorbate (CS) and on hyaluronic acid sodium salt/lysine acetate (HAS) combination. Sponge-like dressings were prepared by freeze-drying and characterized for mechanical resistance and mucoadhesion. CS dressings show hig...

journal_title：Pharmaceutical development and technology

authors： Rossi S,Marciello M,Ferrari F,Puccio A,Bonferoni C,Sandri G,Caramella C

更新日期：2012-03-01 00:00:00

abstract：:Drug release from hydroxypropyl methylcellulose (HPMC) hydrophilic matrix tablets is controlled by drug diffusion through the gel layer of the matrix-forming polymer upon hydration, matrix erosion or combination of diffusion and erosion mechanisms. In this study, the relationship between viscoelastic properties of the...

journal_title：Pharmaceutical development and technology

authors： Hamed R,Al Baraghthi T,Sunoqrot S

更新日期：2018-11-01 00:00:00

abstract：:Purpose: Intestinal drug absorption is one of the main factors that govern the fraction of oral dose absorbed (Fa) of drugs. It is reported that oral absorption of bortezomib (BTZ) can be restricted by its low intestinal permeability. In this study, we aimed to evaluate the impact of self-nanoemulsifying drug delivery...

journal_title：Pharmaceutical development and technology

authors： Mahmoudian M,Valizadeh H,Löbenberg R,Zakeri-Milani P

更新日期：2020-03-01 00:00:00

abstract：:Objective: A polymer-based nanoparticle was constructed to target sorafenib delivery to colorectal carcinoma cells and decrease the side effects of the drug.Methods: Sorafenib-loaded nanoparticles (S-NPs) based on PEG-PLGA were prepared using a double emulsion solvent evaporation method. The properties of S-NPs were e...

journal_title：Pharmaceutical development and technology

authors： Li N,Chen Y,Sun H,Huang T,Chen T,Jiang Y,Yang Q,Yan X,Wu M

更新日期：2020-06-01 00:00:00

abstract：:A high-pressure homogenization method for the production of aqueous suspensions of poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) was investigated. Depending on the production conditions it was possible to produce micro--as well as nanoparticulate systems without the use of organic solvents. The influence of dif...

journal_title：Pharmaceutical development and technology

authors： Calvör A,Müller BW

更新日期：1998-08-01 00:00:00

abstract：:This paper explores the utility of aqueous solubility of structurally similar drugs in predicting optimum conditions for extrusion and spheronization of pellets using response surface methodology. Pharmacologically active xanthine derivatives exhibiting widely varying aqueous solubility were used to determine optimum ...

journal_title：Pharmaceutical development and technology

authors： Hileman GA,Upadrashta SM,Neau SH

更新日期：1997-02-01 00:00:00

abstract：PURPOSE:To investigate the influence of the pH of the dissolution medium on immediate release 850 mg metformin hydrochloride tablets. METHODS:A traditional wet granulation method was used to manufacture metformin hydrochloride tablets with or without a disintegrant. Tablet dissolution was conducted using the USP appar...

journal_title：Pharmaceutical development and technology

authors： Desai D,Wong B,Huang Y,Tang D,Hemenway J,Paruchuri S,Guo H,Hsieh D,Timmins P

更新日期：2015-01-01 00:00:00

abstract：:This study reports on the impact of cyclodextrin addition on the phase behavior of microemulsion systems. Three distinct oil-in-water microemulsions were formulated and subjected to increasing concentrations of various cyclodextrins. The prepared formulations underwent visual, textural and microscopic characterization...

journal_title：Pharmaceutical development and technology

authors： Thakur SS,Solloway J,Stikkelman A,Seyfoddin A,Rupenthal ID

更新日期：2018-02-01 00:00:00

abstract：:Alendronate sodium (ALD) is a bisphosphonate medication used in the treatment and prevention of osteoporosis. Absorption of ALD as oral formulation is very poor (0.5%-1%). Its bioavailability can decrease with food effect. It has some gastrointestinal adverse effects such as gastritis, gastric ulcer, and esophagitis. ...

journal_title：Pharmaceutical development and technology

authors： Asikoğlu M,Ozguney I,Ozcan I,Orumlu O,Guneri T,Koseoğlu K,Ozkilic H

更新日期：2008-01-01 00:00:00

abstract：:Submicron colloidal suspensions of poly(epsilon-caprolactone) (PCL) were prepared by the solvent displacement method, using either the conventional form or a new recirculation device. In the latter case, a process that allows the recirculation of the aqueous phase into a device, providing a continuous flow, is propose...

journal_title：Pharmaceutical development and technology

authors： Piñón-Segundo E,Ganem-Quintanar A,Rafael Garibay-Bermúdez J,Juan Escobar-Chávez J,López-Cervantes M,Quintanar-Guerrero D

更新日期：2006-01-01 00:00:00

abstract：:A new approach to developing a drug-polymer mixed coat for highly water-soluble diltiazem pellets was investigated at different coating levels. Drug layering and the coating procedures were performed using a bottom spray fluidized bed coater. Drug pellets were coated with Eudragit NE40 (NE40) alone and in combination ...

journal_title：Pharmaceutical development and technology

authors： Nisar ur Rahman,Yuen KH,Khan NA,Wong JW

更新日期：2006-02-01 00:00:00

abstract：:Due to their light consistency and good spreadability, aqueous foams are considered as convenient and highly accepted drug carrier systems that are of great importance in the field of topical drug delivery. The production of a stable, easy to dose, preferably environmentally harmless foam formulation is challenging. T...

journal_title：Pharmaceutical development and technology

authors： Farkas D,Kállai-Szabó N,Sárádi-Kesztyűs Á,Lengyel M,Magramane S,Kiss É,Antal I

更新日期：2020-12-27 00:00:00

abstract：:The objective of this study was to develop a floating, pulsatile, multiparticulate drug delivery system intended for chronopharmacotherapy of arthritis. The floating pulsatile drug delivery has the advantage that a drug can be released in the upper gastrointestinal tract after a definite time period of no drug release...

journal_title：Pharmaceutical development and technology

authors： Gaikwad M,Belgamwar VS,Tekade A,Gattani S,Surana S

更新日期：2010-03-01 00:00:00

abstract：:An osmotic-controlled pulsatile delivery technology was developed for targeted drug delivery. This novel system consists of a tablet core surrounded by an osmotic coating that has been mechanically compromised in strategic locations to facilitate reliable drug release at a given time point after administration. The ta...

journal_title：Pharmaceutical development and technology

authors： Rahemba TR,Bell S,Connolly EK,Waterman KC

更新日期：2009-01-01 00:00:00

abstract：:The aim of this research was to develop and assess a new dissolution apparatus for orodispersible films (ODFs). The new apparatus was based on a flow-through cell design which requires only a limited amount of dissolution medium and can automatically collect samples in short-time intervals. Compared with the dissoluti...

journal_title：Pharmaceutical development and technology

authors： Xia Y,Chen F,Zhang H,Luo C

更新日期：2015-05-01 00:00:00

abstract：:Hypericin (Hyp), a natural hydrophobic and photoactive pigment, and methylene blue (MB), a hydrophilic cationic dye, are utilized as photosensitizer (PS) for photodynamic therapy of cancer. Bioadhesive and thermoresponsive polymeric systems can improve the drug availability by increasing the contact time between the s...

journal_title：Pharmaceutical development and technology

authors： Borghi-Pangoni FB,Junqueira MV,Bruschi ML

更新日期：2020-04-01 00:00:00

abstract：:The effect of six factors: spray gun, formulation, inlet temperature, atomizing air pressure, fan air pressure, and gun-bed distance, on the final adhesion of the film coat to the tablet core were assessed. The method used was based on an experimental design, Resolution IV, that allowed the main effects to be free fro...

journal_title：Pharmaceutical development and technology

authors： Khan H,Fell JT,Macleod GS

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:The purpose of this study is to investigate the mechanisms and thermodynamics of the interaction between hydroxypropyl beta-cyclodextrin (HPdetaCD) and [D-Trp6, des-Gly10] LHRH ethylamide (deslorelin), a peptide drug. METHODS:We used UV and fluorescence spectroscopy to study the interaction of HPbetaCD and des...

journal_title：Pharmaceutical development and technology

authors： Koushik KN,Bandi N,Kompella UB

更新日期：2001-11-01 00:00:00

abstract：:In this study, we designed a polymersome system for the controlled release of methotrexate (MTX) as an anticancer drug with the objective of improving the loading efficiency of the drug in polymersomes as well as achievement of an efficient control on the release rate of drug from nanocarriers. We synthesized mono met...

journal_title：Pharmaceutical development and technology

authors： Nosrati H,Adinehvand R,Manjili HK,Rostamizadeh K,Danafar H

更新日期：2019-01-01 00:00:00

abstract：:The physicochemical properties and enzymatic stability of esters of phenylephrone, synthesized on the basis of the chemical delivery system (CDS) concept, were studied as a new class of mydriatic agents. Potentiometrically determined ionization constants (pKa) of the novel compounds were in the range 7.19-7.21. The th...

journal_title：Pharmaceutical development and technology

authors： Goskonda VR,Khan MA,Bodor NS,Reddy IK

更新日期：1999-05-01 00:00:00

abstract：:Background: Clindamycin's bitter taste and odor is known to affect treatment adherence in children. Recently, a formulation of clindamycin HCl complexed with ion exchange resin IRP 69 was shown to mask the bitter taste. Because of the potential benefit of this formulation for children, a pilot study using a porcine mo...

journal_title：Pharmaceutical development and technology

authors： Goode GA,Wagh SJ,Irby DJ,Ma D,Jacobs RF,Kearns GL,Almoazen H

更新日期：2019-10-01 00:00:00

abstract：:We have proposed a theory indicating the correlation between the dissolution rate and the heat of solution of drug substances. The initial dissolution rates of the drug substances containing amorphous were predicted accurately from their heats of solution. In this report, the possibility for the theory to estimate the...

journal_title：Pharmaceutical development and technology

authors： Yoshihashi Y,Yonemochi E,Terada K

更新日期：2002-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of solid carriers and processing routes on the properties of amorphous solid dispersions of itraconazole. Three solid carriers with a range of surface properties were studied, (1) a mesoporous silicate, magnesium aluminum silicate (Neusilin US2), (2) a nonporous sil...

journal_title：Pharmaceutical development and technology

authors： Grobelny P,Kazakevich I,Zhang D,Bogner R

更新日期：2015-01-01 00:00:00