Abstract:
:It is well known that carriers can affect the dissolution of poorly soluble drugs. In this study, our aim was to investigate the dissolution enhancement of carbamazepine solid dispersed or mixed at different loading ratios in crospovidone, polyvinylpyrrolidone, and sodium starch glycolate. The physical state of the drug and the drug-polymer interactions in the solid state were investigated using differential scanning calorimetry (DSC) and x-ray diffraction analysis (XRD). Through the solubilization kinetics and dissolution rates studies, the in vitro drug availability of the systems was evaluated. An improved in vitro dissolution of the drug was obtained in all the binary systems that increased as the polymer content increased.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Moneghini M,Voinovich D,Perissutti B,Princivalle Fdoi
10.1081/pdt-120005725subject
Has Abstractpub_date
2002-01-01 00:00:00pages
289-96issue
3eissn
1083-7450issn
1097-9867journal_volume
7pub_type
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