Abstract:
:The purpose of this paper was to investigate the effect of several experimental variables on the ability of a neural network to predict in vitro dissolution rate as a function of product formulation changes. Neural network software was trained with sets of hypothetical and experimental data consisting of 4-15 formulations with known in vitro drug dissolution profiles and the ability of the trained model to recognize patterns was validated against similar formations not used to train the neural network. The effect of selected variables, e.g., number of hidden-layer nodes and iterations, as well as the use of replicate or mean data on the accuracy of the predictions was investigated. The importance of optimizing the number of hidden-layer nodes and iterations was demonstrated. The prediction error increased for validation data sets that were outside the range of the training data set. Accurate predictions were obtained with as few as four formulations in the training set, provided the formulations were carefully chosen, and the number of formulation variables were small. Also, limiting the validation set to one formulation was not sufficient to validate the neural network model. Increasing the size of the training set, or replication of the input and output data, also provided more accurate predictions. The neural network accurately predicted in vitro drug release provided the neural network variables were optimized, and the training and validation data sets were appropriately selected.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Ebube NK,McCall T,Chen Y,Meyer MCdoi
10.3109/10837459709031442subject
Has Abstractpub_date
1997-08-01 00:00:00pages
225-32issue
3eissn
1083-7450issn
1097-9867journal_volume
2pub_type
杂志文章abstract::This paper proposes the development of a drug product Manufacturing Classification System (MCS) based on processing route. It summarizes conclusions from a dedicated APS conference and subsequent discussion within APS focus groups and the MCS working party. The MCS is intended as a tool for pharmaceutical scientists t...
journal_title:Pharmaceutical development and technology
pub_type: 杂志文章,评审
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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doi:10.3109/10837450.2014.920358
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abstract:PURPOSE:To evaluate four novel metrics that compare dissolution profiles and assess their performance characteristics by comparing dissolution profiles of FAST and SLOW immediate release metoprolol tartrate tablets. METHODS:The four novel metrics (rho, rho m, delta a, and delta s), along with f2, were applied to disso...
journal_title:Pharmaceutical development and technology
pub_type: 杂志文章
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abstract::The aim of this study was to investigate intravitreal injection of silk fibroin nanoparticles (SFNs) encapsulating bio-macromolecules, achieving enhanced drug bioavailability, and extended retention in retina. SFNs were prepared with regenerated silk fibroin using desolvation method with fluorescein isothiocyanate lab...
journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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abstract::Poor solubility and bioavailability of drugs are often affected by its microscopic structural properties. Nitrofurantoin (NF), a Biopharmaceutics Classification System class II item, has a low water solubility with low plasma concentrations. To improve its therapeutic efficacy, formulation strategy of solid dispersion...
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abstract::Novel fast-disintegrating multi-unit tablets (FDMUTs) were prepared to modify the release of lornoxicam (a potent non-steroidal anti-inflammatory drug with a short half-life) as well as to combine the advantages of multi-unit systems with the cost-effectiveness of compressed tablets. The proposed FDMUTs consisted of s...
journal_title:Pharmaceutical development and technology
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abstract::The aim of this study was to prepare a highly porous multiparticulate dosage form containing cilostazol for gastroretentive drug delivery. The floating pellets were prepared with glyceryl behenate as a matrix former and camphor as a sublimating agent by extrusion/spheronization and sublimation under vacuum. Granules p...
journal_title:Pharmaceutical development and technology
pub_type: 杂志文章
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journal_title:Pharmaceutical development and technology
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doi:10.1080/10837450.2017.1312440
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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abstract::The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. Fluvastatin (FLV) samples were characterized by several techniqu...
journal_title:Pharmaceutical development and technology
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doi:10.3109/10837450.2012.727000
更新日期:2013-03-01 00:00:00
abstract::A colchicine release system utilizing biodegradable poly(phosphazenes) was investigated in vitro for intra-articular administration. Polymer degradation and drug release studies were performed on colchicine-loaded poly(phosphazenes) containing either imidazolyl (I-PPHOS) or ethyl glycinato (EG-PPHOS) side chain substi...
journal_title:Pharmaceutical development and technology
pub_type: 杂志文章
doi:10.3109/10837459809028479
更新日期:1998-02-01 00:00:00
abstract::Purpose: Intestinal drug absorption is one of the main factors that govern the fraction of oral dose absorbed (Fa) of drugs. It is reported that oral absorption of bortezomib (BTZ) can be restricted by its low intestinal permeability. In this study, we aimed to evaluate the impact of self-nanoemulsifying drug delivery...
journal_title:Pharmaceutical development and technology
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abstract::Taking into account possible irritation of the skin upon contact with naproxen (NPX) crystals and lower bioavailability after administration of the suspended or ionized drug, the aim of the work was to design and characterize novel and easy-to-formulate gels with the entirely dissolved drug in the acidic form. The for...
journal_title:Pharmaceutical development and technology
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doi:10.3109/10837450.2015.1135342
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abstract::The utility of microcalorimetry as a rapid screening tool for assessing the solution stability of high molecular weight pharmaceutical proteins was evaluated by using model recombinant antibodies, Protein I and Protein II. Changes in the transition midpoint, T(m), were monitored as a function of pH and/or in the prese...
journal_title:Pharmaceutical development and technology
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
abstract::It is well known that carriers can affect the dissolution of poorly soluble drugs. In this study, our aim was to investigate the dissolution enhancement of carbamazepine solid dispersed or mixed at different loading ratios in crospovidone, polyvinylpyrrolidone, and sodium starch glycolate. The physical state of the dr...
journal_title:Pharmaceutical development and technology
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更新日期:2002-01-01 00:00:00
abstract::The present work investigated the magnitude of microsphere-induced acute myotoxicity and determined whether this myotoxicity is related to microsphere size and/or reconstitution solvent. Using a high molecular weight poly(dl-lactide-co-glycolide) copolymer, the myotoxicity of two different size microsphere formulation...
journal_title:Pharmaceutical development and technology
pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
abstract::The current work aimed to develop low-density gastroretentive sponges loaded with alfuzosin HCl (ALF) to sustain the rate of drug release, improve its oral bioavailability and deliver it to the main site of absorption. Sponges were developed, according to a 23 full factorial design, by compression of the lyophilized A...
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