Development of an effective liposomal cholesterol ester transfer protein (CETP) vaccine for protecting against atherosclerosis in rabbit model.

abstract：:Seven potential impurities, including by-products, starting materials and intermediates were identified in pharmaceutical substance quetiapine fumarate and characterized by spectroscopic methods (MS, IR, NMR). Based on these methods the structures of the impurities were assigned or confirmed as: impurity I: 2-(phenylt...

journal_title：Pharmaceutical development and technology

authors： Stolarczyk EU,Kaczmarek L,Eksanow K,Kubiszewski M,Glice M,Kutner A

更新日期：2009-01-01 00:00:00

abstract：:Several processing and shipping stresses were investigated for their effect on the physical stability of recombinant human growth hormone (rhGH). These included exposure to air/water interfaces, adsorption to hydrophobic surfaces, freeze-thaw cycles, and temperature. The interfacially and thermally denatured hormone w...

journal_title：Pharmaceutical development and technology

authors： Katakam M,Banga AK

更新日期：1997-05-01 00:00:00

abstract：:The aim of the present study is to prepare risperidone-loaded poly lactic-co-glycolic acid (PLGA) microspheres within microfluidic system and to achieve a formulation with uniform size and monotonic and reproducible release profile. In comparison to batch method, T-junction and serpentine chips were utilized and optim...

journal_title：Pharmaceutical development and technology

authors： Jafarifar E,Hajialyani M,Akbari M,Rahimi M,Shokoohinia Y,Fattahi A

更新日期：2017-09-01 00:00:00

abstract：:The objective of the study was to mask the unpleasant taste of captopril (CPT). Taste masking was achieved by complexation of CPT with a basic ion exchange resin, Dowex® 66, using the batch method. Dowex® 66 was used for the adsorption of CPT, and physical and chemical parameters of the CPT resinates complex were eval...

journal_title：Pharmaceutical development and technology

authors： Chikukwa MTR,Wesoly M,Korzeniowska AB,Ciosek-Skibinska P,Walker RB,Khamanga SMM

更新日期：2020-03-01 00:00:00

abstract：:Background: Lymphatic formations that effectively eradicate the virus in the lymphatic system will be therapeutically advantagous in hepatitis B virus (HBV) infection. Lipid-based formulation is often used to deliver drug via the lymphatic system. Baicalin nanoemulsion may be a promising drug delivery system for impro...

journal_title：Pharmaceutical development and technology

authors： Xu Q,Zhou A,Wu H,Bi Y

更新日期：2019-11-01 00:00:00

abstract：:The aim of the present work was the development of vaginal sponge-like dressings based on chitosan ascorbate (CS) and on hyaluronic acid sodium salt/lysine acetate (HAS) combination. Sponge-like dressings were prepared by freeze-drying and characterized for mechanical resistance and mucoadhesion. CS dressings show hig...

journal_title：Pharmaceutical development and technology

authors： Rossi S,Marciello M,Ferrari F,Puccio A,Bonferoni C,Sandri G,Caramella C

更新日期：2012-03-01 00:00:00

abstract：:The main objective of this study was to design positively charged Levofloxacin Hemihydrate (Levo-h)-loaded nanoparticles with improved entrapment efficiency and antibacterial activity. PLGA alone or in combinations with Eudragit® RLPO or RS30D with or without positively charged inducing agent; 1,2-dioleoyl-3-trimethyl...

journal_title：Pharmaceutical development and technology

authors： Hasan AA,Sabry SA,Abdallah MH,El-Damasy DA

更新日期：2016-09-01 00:00:00

abstract：CONTEXT:Bioadhesiviness of polyacrylic acid polymers make them promising hydrogels to design topical drug delivery systems, allowing a close contact with biological substrate as well as an enhanced local concentration gradient, both factors that may improve the biological performance of the drugs. AIM:Texture and bioa...

journal_title：Pharmaceutical development and technology

authors： Calixto G,Yoshii AC,Rocha e Silva H,Stringhetti Ferreira Cury B,Chorilli M

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Theoretical models of the freeze-drying process are potentially useful to guide the design of a freeze-drying process as well as to obtain information not readily accessible by direct experimentation, such as moisture distribution and glass transition temperature, Tg, within a vial during processing. Previ...

journal_title：Pharmaceutical development and technology

authors： Pikal MJ,Cardon S,Bhugra C,Jameel F,Rambhatla S,Mascarenhas WJ,Akay HU

更新日期：2005-01-01 00:00:00

abstract：:The first-line therapy for moderate to severe benign prostatic hyperplasia is the oral therapy by alfuzosin hydrochloride. Unfortunately, the oral therapy of alfuzosin is associated with several route-specific systemic side-effects. The current study was aimed to develop a prototype transdermal patch system for alfuzo...

journal_title：Pharmaceutical development and technology

authors： Nair AB,Vaka SR,Gupta S,Repka MA,Murthy SN

更新日期：2012-03-01 00:00:00

abstract：CONTEXT:Teicoplanin is a glycopeptide antibiotic consisting of a combination of different active components. Clinical equivalence between different batches of this drug is not guaranteed by the present pharmacopeial specification of chemical composition based on an HPLC chromatogram. OBJECTIVE:To test a modification o...

journal_title：Pharmaceutical development and technology

authors： Boix-Montañes A,Garcia-Arieta A

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:BMS-196843 (Oncostatin M) is a therapeutic recombinant protein in development. Scale-up process changes led to unexpected instability of the bulk drug substance solution during storage. A product with an apparent higher MW than the parent protein was observed by the size-exclusion chromatography (SEC). This stu...

journal_title：Pharmaceutical development and technology

authors： Zhao F,Stein DJ,Paborji M,Cash PW,Root BJ,Wei Z,Knupp CJ

更新日期：2001-01-01 00:00:00

abstract：:The objective of the present work is to investigate the presence or absence of a critical concentration of maize starch according to the percolation theory for a truly ternary system with respect to a minimum disintegration time. The results of this study show that the application of percolation theory is not limited ...

journal_title：Pharmaceutical development and technology

authors： Kimura G,Puchkov M,Betz G,Leuenberger H

更新日期：2007-01-01 00:00:00

abstract：:Pulmonary delivery of peptides remains an important, noninvasive route of administration that is attractive because it offers high bioavailability and patient compliance. Optimization of particle characteristics for deposition in the deep regions of the lung after inhalation and retention of peptide stability are key ...

journal_title：Pharmaceutical development and technology

authors： Poursina N,Vatanara A,Rouini MR,Gilani K,Rouholamini Najafabadi A

更新日期：2017-09-01 00:00:00

abstract：:The aim of the present work was to investigate the possibility of achieving buccal delivery of a problematic drug, acyclovir, from films based on chitosan hydrochloride (HCS) and polyacrylic acid sodium salt (PAA). At first, the ionic interaction between HCS and PAA in distilled water was investigated by means of rheo...

journal_title：Pharmaceutical development and technology

authors： Rossi S,Sandri G,Ferrari F,Bonferoni MC,Caramella C

更新日期：2003-01-01 00:00:00

abstract：:Vardenafil hydrochloride (VAR) is an erectile dysfunction treating drug. VAR has a short elimination half-life (4-5 h) and suffers low oral bioavailability (15%). This work aimed to explore the dual potential of VAR-dendrimer complexes as drug release modulators and oral bioavailability enhancers. VAR-dendrimer comple...

journal_title：Pharmaceutical development and technology

authors： Tawfik MA,Tadros MI,Mohamed MI

更新日期：2019-03-01 00:00:00

abstract：:This paper explores the utility of aqueous solubility of structurally similar drugs in predicting optimum conditions for extrusion and spheronization of pellets using response surface methodology. Pharmacologically active xanthine derivatives exhibiting widely varying aqueous solubility were used to determine optimum ...

journal_title：Pharmaceutical development and technology

authors： Hileman GA,Upadrashta SM,Neau SH

更新日期：1997-02-01 00:00:00

abstract：:In the pharmaceutical industry, chemometrics is rapidly establishing itself as a tool that can be used at every step of product development and beyond: from early development to commercialization. This set of multivariate analysis methods allows the extraction of information contained in large, complex data sets thus ...

journal_title：Pharmaceutical development and technology

authors： Ferreira AP,Tobyn M

更新日期：2015-01-01 00:00:00

abstract：:Novel fast-disintegrating multi-unit tablets (FDMUTs) were prepared to modify the release of lornoxicam (a potent non-steroidal anti-inflammatory drug with a short half-life) as well as to combine the advantages of multi-unit systems with the cost-effectiveness of compressed tablets. The proposed FDMUTs consisted of s...

journal_title：Pharmaceutical development and technology

authors： Aburahma MH,Hamza Yel-S

更新日期：2011-08-01 00:00:00

abstract：:Films of gellan gum:pectin blends were prepared by solvent casting method. Gellan gum:pectin mass ratios were varied (4:1; 1:1; 1:4) at different concentrations (3% or 4%) and glycerol was used as plasticizer (1 or 2%). The films were thin (18-30 µm), translucent, flexible, and homogeneous. The surface pH was suitable...

journal_title：Pharmaceutical development and technology

authors： Prezotti FG,Siedle I,Boni FI,Chorilli M,Müller I,Cury BSF

更新日期：2020-02-01 00:00:00

abstract：:The binding mechanism of tablets prepared by single-step granulation/tabletting (SSGT), a novel technique for the production of tablets, was evaluated. SSGT yielded hard tablets having a short disintegration time due to their porous, spongelike internal structure. Calculation of the interaction factor and electrical c...

journal_title：Pharmaceutical development and technology

authors： Vermeire A,Keleb EI,Kiekens F,Van Driessche I,Hoste S,Remon JP,Vervaet C

更新日期：2005-01-01 00:00:00

abstract：:Our previous study reported that the Design Expert® Software showed a beneficial role in the development of microemulsions (ME) for transdermal drug delivery. To fully confirm the reproducibility and the reliability of simultaneous optimal ME formulations, the optimal ME formulations predicted by the Design Expert® So...

journal_title：Pharmaceutical development and technology

authors： Duangjit S,Chairat W,Opanasopit P,Rojanarata T,Ngawhirunpat T

更新日期：2016-09-01 00:00:00

abstract：:A colchicine release system utilizing biodegradable poly(phosphazenes) was investigated in vitro for intra-articular administration. Polymer degradation and drug release studies were performed on colchicine-loaded poly(phosphazenes) containing either imidazolyl (I-PPHOS) or ethyl glycinato (EG-PPHOS) side chain substi...

journal_title：Pharmaceutical development and technology

authors： Ibim SM,el-Amin SF,Goad ME,Ambrosio AM,Allcock HR,Laurencin CT

更新日期：1998-02-01 00:00:00

abstract：:The present study details the development of a small-scale spray-drying approach for the routine screening of amorphous solid dispersions (ASDs). This strategy aims to overcome the limitations of standard screening methodologies like solvent casting and quench cooling to predict drug-polymer miscibility of spray-dried...

journal_title：Pharmaceutical development and technology

authors： Ousset A,Bassand C,Chavez PF,Meeus J,Robin F,Schubert MA,Somville P,Dodou K

更新日期：2019-06-01 00:00:00

abstract：:Objective: Tanshinone IIA (TSN) and Tetramethylpyrazine (TMP) were combined in a composite, oil-in-water nanoemulsions (TSN/TMP O/W NEs) was prepared to prolong in vitro and vivo circulation time, and enhance the bioavailability of TSN. Material and methods: Physicochemical characterization of TSN/TMP O/W NEs was char...

journal_title：Pharmaceutical development and technology

authors： Wang B,Hong L,Liu Y,Bedingfield SK,Zhang C,Peng C,Qian J,Zha L

更新日期：2019-12-01 00:00:00

abstract：:The taste of oral dosage forms is an important argument regarding patient's compliance and acceptability. For this reason, it is often necessary to mask an undesirable and unpleasant taste of an active pharmaceutical ingredient. The purpose of this study was to mask the taste of naproxen sodium by a new fluid-bed coat...

journal_title：Pharmaceutical development and technology

authors： Stange U,Führling C,Gieseler H

更新日期：2014-03-01 00:00:00

abstract：:The objective of the study was to develop a mathematical model for predicting the disintegration time of fast disintegrating tablets (FDTs) by estimating the powder characteristics of powder blend prior to compression. A combination of chitosan-alginate complex and glycine in the ratio of 50:50 was used for preparing ...

journal_title：Pharmaceutical development and technology

authors： Goel H,Arora A,Tiwary AK,Rana V

更新日期：2011-02-01 00:00:00

abstract：:The objective of this study was to develop a floating, pulsatile, multiparticulate drug delivery system intended for chronopharmacotherapy of arthritis. The floating pulsatile drug delivery has the advantage that a drug can be released in the upper gastrointestinal tract after a definite time period of no drug release...

journal_title：Pharmaceutical development and technology

authors： Gaikwad M,Belgamwar VS,Tekade A,Gattani S,Surana S

更新日期：2010-03-01 00:00:00

abstract：:A new approach to developing a drug-polymer mixed coat for highly water-soluble diltiazem pellets was investigated at different coating levels. Drug layering and the coating procedures were performed using a bottom spray fluidized bed coater. Drug pellets were coated with Eudragit NE40 (NE40) alone and in combination ...

journal_title：Pharmaceutical development and technology

authors： Nisar ur Rahman,Yuen KH,Khan NA,Wong JW

更新日期：2006-02-01 00:00:00

abstract：:Letrozole (LTZ), an aromatase inhibitor used for the treatment of hormonally-positive breast cancer in postmenopausal women, has poor water solubility, rapid metabolism, and a range of side effects. In this study, polymer-based nanoparticles (NPs) incorporating the drug have been designed and characterized, aimed to c...

journal_title：Pharmaceutical development and technology

authors： Alemrayat B,Elhissi A,Younes HM

更新日期：2019-02-01 00:00:00