Abstract:
:The binding mechanism of tablets prepared by single-step granulation/tabletting (SSGT), a novel technique for the production of tablets, was evaluated. SSGT yielded hard tablets having a short disintegration time due to their porous, spongelike internal structure. Calculation of the interaction factor and electrical conductance tests confirmed the presence of solid bridges that provided a higher tensile strength to these compacts in comparison to tablets prepared by conventional tabletting techniques. At high relative humidity, moisture sorption and glass-to-rubber transition of the binder (polyvinylpyrrolidone), or condensation of moisture on the internal pore surface, reduced the tensile strength of the SSGT-manufactured tablets. Contrary to tablets prepared by granulation and compression, the SSGT tablets did not harden during storage under conditions of varying relative humidity (alternating the relative humidity every 24 hr between 33% and 75%).
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Vermeire A,Keleb EI,Kiekens F,Van Driessche I,Hoste S,Remon JP,Vervaet Cdoi
10.1081/pdt-65690subject
Has Abstractpub_date
2005-01-01 00:00:00pages
397-403issue
3eissn
1083-7450issn
1097-9867journal_volume
10pub_type
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