Abstract:
:Films of gellan gum:pectin blends were prepared by solvent casting method. Gellan gum:pectin mass ratios were varied (4:1; 1:1; 1:4) at different concentrations (3% or 4%) and glycerol was used as plasticizer (1 or 2%). The films were thin (18-30 µm), translucent, flexible, and homogeneous. The surface pH was suitable for buccal application. All films reached high mechanical resistance and the mucoadhesive ability of them was evidenced. High ratio of gellan gum improved the mechanical resistance and the mucoadhesion of the films as well as the control of drug release rates. The films did not disintegrate in simulate saliva up to 24 h and curcumin release could be sustained up to 12 h. The set of data evidence that the films designed in this work represent a potential platform for buccal drug delivery.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Prezotti FG,Siedle I,Boni FI,Chorilli M,Müller I,Cury BSFdoi
10.1080/10837450.2019.1682608subject
Has Abstractpub_date
2020-02-01 00:00:00pages
159-167issue
2eissn
1083-7450issn
1097-9867journal_volume
25pub_type
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