Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery.

Abstract:

:Films of gellan gum:pectin blends were prepared by solvent casting method. Gellan gum:pectin mass ratios were varied (4:1; 1:1; 1:4) at different concentrations (3% or 4%) and glycerol was used as plasticizer (1 or 2%). The films were thin (18-30 µm), translucent, flexible, and homogeneous. The surface pH was suitable for buccal application. All films reached high mechanical resistance and the mucoadhesive ability of them was evidenced. High ratio of gellan gum improved the mechanical resistance and the mucoadhesion of the films as well as the control of drug release rates. The films did not disintegrate in simulate saliva up to 24 h and curcumin release could be sustained up to 12 h. The set of data evidence that the films designed in this work represent a potential platform for buccal drug delivery.

journal_name

Pharm Dev Technol

authors

Prezotti FG,Siedle I,Boni FI,Chorilli M,Müller I,Cury BSF

doi

10.1080/10837450.2019.1682608

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

159-167

issue

2

eissn

1083-7450

issn

1097-9867

journal_volume

25

pub_type

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