Abstract:
:The objective of the study was to mask the unpleasant taste of captopril (CPT). Taste masking was achieved by complexation of CPT with a basic ion exchange resin, Dowex® 66, using the batch method. Dowex® 66 was used for the adsorption of CPT, and physical and chemical parameters of the CPT resinates complex were evaluated. A central composite design was used to generate the experiments for the manufacture of resinates using different process and formulation variables. In vitro dissolution studies were performed for 2 h in 0.01N HCl (pH 1.6) using USP Apparatus I. The compatibility of CPT and the resin was evaluated by Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD). The resinates were evaluated for micromeritic properties and further characterised using FTIR, DSC, and PXRD. Response surface methodology was used to determine the significance of input variables on the CPT content and release. The CPT resin ratio was found to have a significant impact on content of the resinates and on CPT release. The formulations were also studied for taste masking ability by means of an electronic gustatory system - electronic tongue.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Chikukwa MTR,Wesoly M,Korzeniowska AB,Ciosek-Skibinska P,Walker RB,Khamanga SMMdoi
10.1080/10837450.2019.1687520subject
Has Abstractpub_date
2020-03-01 00:00:00pages
281-289issue
3eissn
1083-7450issn
1097-9867journal_volume
25pub_type
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