Abstract:
CONTEXT:Bioadhesiviness of polyacrylic acid polymers make them promising hydrogels to design topical drug delivery systems, allowing a close contact with biological substrate as well as an enhanced local concentration gradient, both factors that may improve the biological performance of the drugs. AIM:Texture and bioadhesive properties of hydrogels were assessed by using texture analyzer and they were correlated with their rheological behavior and performance as drug delivery systems. METHODS:Aqueous dispersions of both polymers were prepared at 0.5%, 1.0% and 1.5% w/v. Hardness, compressibility, adhesiveness, cohesiveness, bioadhesion, continuous flow, oscillatory dynamic test and in vitro drug release were evaluated. RESULTS:Rheological and texture parameters were dependent on polymer concentration and C974P polymer built the strongest structures. Both 1.5% hydrogels presented high bioadhesion values. About 50% of the metronidazole (MTZ) was sustained released from hydrogels within 2 h with an initial burst release at early stage. After, the release rates were decreased and 10% of the MTZ was released in the next 10 h. The drug release process was driven by Fickian diffusion and complex mechanism for PP and C974P hydrogels, respectively. CONCLUSION:The set of results demonstrated that these hydrogels are promising to be used as topical controlled drug delivery system.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Calixto G,Yoshii AC,Rocha e Silva H,Stringhetti Ferreira Cury B,Chorilli Mdoi
10.3109/10837450.2014.882941subject
Has Abstractpub_date
2015-06-01 00:00:00pages
490-6issue
4eissn
1083-7450issn
1097-9867journal_volume
20pub_type
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