Novel platens to measure the hardness of a pentagonal shaped tablet.

abstract：:The objective of this study was to develop a floating, pulsatile, multiparticulate drug delivery system intended for chronopharmacotherapy of arthritis. The floating pulsatile drug delivery has the advantage that a drug can be released in the upper gastrointestinal tract after a definite time period of no drug release...

journal_title：Pharmaceutical development and technology

authors： Gaikwad M,Belgamwar VS,Tekade A,Gattani S,Surana S

更新日期：2010-03-01 00:00:00

abstract：:The physical-chemical processing variables affecting particle size following precipitation using the supercritical antisolvent (SAS) method were investigated by varying both the composition of the feed solvent and the structure of the solute, using a series of steroids. The key factor influencing particle size in thes...

journal_title：Pharmaceutical development and technology

authors： Sacha GA,Schmitt WJ,Nail SL

更新日期：2006-01-01 00:00:00

abstract：:The objective of this study was to compare the dissolution behavior of tablets prepared from solid dispersions with and without drug-carrier interactions. Diazepam and nifedipine were used as model drugs. Two types of carriers were used; polyvinylpyrrolidone (PVP K12, K30 and K60) and saccharides (inulin 1.8 kDa, 4 kD...

journal_title：Pharmaceutical development and technology

authors： Srinarong P,Kouwen S,Visser MR,Hinrichs WL,Frijlink HW

更新日期：2010-09-01 00:00:00

abstract：:It is well known that carriers can affect the dissolution of poorly soluble drugs. In this study, our aim was to investigate the dissolution enhancement of carbamazepine solid dispersed or mixed at different loading ratios in crospovidone, polyvinylpyrrolidone, and sodium starch glycolate. The physical state of the dr...

journal_title：Pharmaceutical development and technology

authors： Moneghini M,Voinovich D,Perissutti B,Princivalle F

更新日期：2002-01-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of the composition of a binary powder mixture on the bonding index, the brittle fracture index, and the strain index, as defined by Hiestand. The studies involved tensile strength and dynamic indentation hardness determinations of square compacts, the solid fract...

journal_title：Pharmaceutical development and technology

authors： Majuru S,Wurster DE

更新日期：1997-11-01 00:00:00

abstract：:The main purpose of this work was to develop a supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) of carbamazepine (CBZ). S-SMEDDS of CBZ was prepared and drug precipitation behavior, dissolution rate in vitro and particle size distribution were evaluated. The relative bioavailability of S-SMEDDS f...

journal_title：Pharmaceutical development and technology

authors： Zhang N,Zhang W,Jin Y,Quan DQ

更新日期：2011-08-01 00:00:00

abstract：:The purpose of this study was to assess the usefulness of waxy corn (maize) starch as a cofiller and diluent in pellets produced by aqueous extrusion-spheronization. Waxy corn starch was combined with microcrystalline cellulose (MCC) in the range of 20-50% of the entire composition. Pellets containing ordinary corn st...

journal_title：Pharmaceutical development and technology

authors： Junnila R,Palviainen P,Heinämäki J,Myllärinen P,Forssell P,Yliruusi J

更新日期：2000-01-01 00:00:00

abstract：:The first-line therapy for moderate to severe benign prostatic hyperplasia is the oral therapy by alfuzosin hydrochloride. Unfortunately, the oral therapy of alfuzosin is associated with several route-specific systemic side-effects. The current study was aimed to develop a prototype transdermal patch system for alfuzo...

journal_title：Pharmaceutical development and technology

authors： Nair AB,Vaka SR,Gupta S,Repka MA,Murthy SN

更新日期：2012-03-01 00:00:00

abstract：:In the current study, we demonstrate a structured approach to downstream process development for spray dried amorphous solid dispersions. Direct compression is generally not suitable due to typically poor flow of spray dried powders in tablets. Roller compaction (RC) is therefore the method of choice to enable spray d...

journal_title：Pharmaceutical development and technology

authors： Henriques J,Moreira J,Doktorovová S

更新日期：2021-01-04 00:00:00

abstract：:Bupivacaine lipid microparticles were prepared and evaluated as a parenteral sustained-release dosage form for postoperative pain management. Bupivacaine free base was incorporated into a molten tristearin matrix and lipid micro-particles were subsequently formed from this molten mixture by a spray-congealing process....

journal_title：Pharmaceutical development and technology

authors： Li LC,Zhu L,Song JF,Deng JS,Bandopadhyay R,Wurster DE

更新日期：2005-01-01 00:00:00

abstract：:In the present study, Simvastatin was incorporated in emulsion of soybean oil and propylene glycol monocaprylate as oily phase and Tween 80 and Cremophor EL as surfactants and also their mixtures. Dry adsorbed emulsions were prepared by using colloidal silicon dioxide in varying proportions to adsorb the liquid emulsi...

journal_title：Pharmaceutical development and technology

authors： Dixit RP,Nagarsenker MS

更新日期：2007-01-01 00:00:00

abstract：:Flecainide base is pharmaceutically active substance used for production of flecainide acetate which is known in market as Tambacor, Almarytm, Apocard, Ecrinal or Flecaine. It is determined that flecainide base forms four polymorphic forms abbreviated as Ib, IIb, IIIb and IVb. Flecainide base form Ib is thermodynamica...

journal_title：Pharmaceutical development and technology

authors： Veldre K,Eglīte Z,Actiņš A,Zvirgzdiņš A,Rozenberga L,Tamanis E

更新日期：2014-02-01 00:00:00

abstract：:A novel analytical procedure has been developed for quantitative determination of levodopa and carbidopa in aqueous binary solutions acidified by HCl and without any other sample pretreatment. The method is based partially on least squares treatment of data obtained by attenuated total reflectance Fourier transform in...

journal_title：Pharmaceutical development and technology

authors： Khanmohammadi M,Mobedi E,Garmarudi AB,Mobedi H,Kargosha K

更新日期：2007-01-01 00:00:00

abstract：:Dynamic image analysis (DIA) was used to measure particle diameter (D50) of in-process samples removed during fluid bed coating. A single, rapid measurement gave D50 to within 4 mum. Samples removed at intervals of 2% weight gain were readily distinguishable by DIA and by their drug release profiles. Drug release was ...

journal_title：Pharmaceutical development and technology

authors： Heinicke G,Schwartz JB

更新日期：2006-01-01 00:00:00

abstract：:The interaction of 5-nitro-2-furfurilylidene benzhydrazide (5NFB), potential anti-trypanosomal compound, with micellar solutions was studied. The results indicated that 50 mug of 5NFB completely kills 20 million T. cruzi epimastigote cells within 3 days, whereas the same amount of benznidazole kills 30% of the cells a...

journal_title：Pharmaceutical development and technology

authors： Rangel-Yagui CO,Hsu HW,Barbosa LR,Caetano W,Pessoa A Jr,Tavares LC,Itri R

更新日期：2007-01-01 00:00:00

abstract：:New microspheres containing hydrophilic core and hydrophobic coating as a controlled-release system with no toxic reagents were proposed. Water in oil in water (W/O/W) emulsion and solvent evaporation methods were used to make chitosan/ cellulose acetate (CCA) microspheres sized 200 - 400 microm. Ranitidine hydrochlor...

journal_title：Pharmaceutical development and technology

authors： Zhou HY,Chen XG,Liu CS,Meng XH,Yu LJ,Liu XY,Liu N

更新日期：2005-01-01 00:00:00

abstract：:The objective of the study was to mask the unpleasant taste of captopril (CPT). Taste masking was achieved by complexation of CPT with a basic ion exchange resin, Dowex® 66, using the batch method. Dowex® 66 was used for the adsorption of CPT, and physical and chemical parameters of the CPT resinates complex were eval...

journal_title：Pharmaceutical development and technology

authors： Chikukwa MTR,Wesoly M,Korzeniowska AB,Ciosek-Skibinska P,Walker RB,Khamanga SMM

更新日期：2020-03-01 00:00:00

abstract：:The binding mechanism of tablets prepared by single-step granulation/tabletting (SSGT), a novel technique for the production of tablets, was evaluated. SSGT yielded hard tablets having a short disintegration time due to their porous, spongelike internal structure. Calculation of the interaction factor and electrical c...

journal_title：Pharmaceutical development and technology

authors： Vermeire A,Keleb EI,Kiekens F,Van Driessche I,Hoste S,Remon JP,Vervaet C

更新日期：2005-01-01 00:00:00

abstract：:The effect of six factors: spray gun, formulation, inlet temperature, atomizing air pressure, fan air pressure, and gun-bed distance, on the final adhesion of the film coat to the tablet core were assessed. The method used was based on an experimental design, Resolution IV, that allowed the main effects to be free fro...

journal_title：Pharmaceutical development and technology

authors： Khan H,Fell JT,Macleod GS

更新日期：2005-01-01 00:00:00

abstract：:The purpose of this study was a comparative evaluation of miniaturized vs. University of Minnesota's (i.e., U of Minn. = Hiestand's) procedures for determining the tensile strength, indentation hardness, and bonding index (BI), one out of three Indices of Tableting Performance (ITP). Tableting properties of six direct...

journal_title：Pharmaceutical development and technology

authors： Lamey K,Schwartz J,Muller F

更新日期：2003-08-01 00:00:00

abstract：:This work aimed to incorporate Dexibuprofen (DXI), the pharmacologically active and more potent form of ibuprofen, into polymeric micelles based tablets with enhanced oral bioavailability. Thin film hydration technique was employed to prepare DXI polymeric micelles using Pluronic® F127 and/or P123 solutions in differe...

journal_title：Pharmaceutical development and technology

authors： Abdelbary G,Makhlouf A

更新日期：2014-09-01 00:00:00

abstract：:In the pharmaceutical industry, chemometrics is rapidly establishing itself as a tool that can be used at every step of product development and beyond: from early development to commercialization. This set of multivariate analysis methods allows the extraction of information contained in large, complex data sets thus ...

journal_title：Pharmaceutical development and technology

authors： Ferreira AP,Tobyn M

更新日期：2015-01-01 00:00:00

abstract：:The aim of this study was to prepare various types of solid dispersions (SDs) by the hot-melt extrusion technique. Next, process analytical technology (PAT) such as Fourier transform-infrared (FT-IR) and Raman and near infrared (NIR) spectroscopy were applied to determine the solubilization effect. The SDs and its tab...

journal_title：Pharmaceutical development and technology

authors： Hwang I,Renuka V,Lee JH,Weon KY,Kang CY,Lee BJ,Park JB

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Theoretical models of the freeze-drying process are potentially useful to guide the design of a freeze-drying process as well as to obtain information not readily accessible by direct experimentation, such as moisture distribution and glass transition temperature, Tg, within a vial during processing. Previ...

journal_title：Pharmaceutical development and technology

authors： Pikal MJ,Cardon S,Bhugra C,Jameel F,Rambhatla S,Mascarenhas WJ,Akay HU

更新日期：2005-01-01 00:00:00

abstract：:The key for better antitumor efficacy is to improve the specificity of antitumor drugs for tumor cells and diminish their cytotoxicity to normal tissues. Targeted nanoparticles as antitumor drug delivery system can resolve this problem. In this study, we prepared folate and TAT (arginine-rich cell-penetrating peptide)...

journal_title：Pharmaceutical development and technology

authors： Zhang S,Liu Y,Gan Y,Qiu N,Gu Y,Zhu H

更新日期：2019-02-01 00:00:00

abstract：:The instability of protein and antigen(s) during encapsulation in biodegradable polymers by water-in-oil-in-water (w/o/w) encapsulation is well established. The aim of present study is to screen various additives to prevent the inactivation and loss of immunogenicity of HBsAg upon its exposure to the water/CH(2)Cl(2) ...

journal_title：Pharmaceutical development and technology

authors： Tomar P,Giri N,Karwasara VS,Pandey RS,Dixit VK

更新日期：2012-07-01 00:00:00

abstract：:Aluminum hydroxide adjuvant was pretreated with six concentrations of potassium dihydrogen phosphate to produce a series of adjuvants with various degrees of phosphate substitution for surface hydroxyl. The adsorption of three phosphorylated proteins (alpha casein, dephosphorylated alpha casein, and ovalbumin) by the ...

journal_title：Pharmaceutical development and technology

authors： Iyer S,HogenEsch H,Hem SL

更新日期：2003-01-01 00:00:00

abstract：:Stability of captopril in a controlled release formulation has been a challenge for some time. The sustained release of captopril from floating matrices has been studied varying the antioxidant load, the sodium bicarbonate proportion and the compaction pressure. Although in many cases the effect of compaction pressure...

journal_title：Pharmaceutical development and technology

authors： Jiménez-Martínez I,Domínguez-Ramírez AM,Villafuerte-Robles L

更新日期：2009-07-22 00:00:00

abstract：:The aim of this work is development of a nontoxic, long-term stable solid lipid nanoparticles (SLN) formulation for the loading of Nimesulide (NiM) by a 22 factorial design. The optimized formulation was composed of 10 wt% of glyceryl behenate and 2.5 wt% of poloxamer 188. Immediately after production, Z-Ave of NiM-SL...

journal_title：Pharmaceutical development and technology

authors： Campos JR,Fernandes AR,Sousa R,Fangueiro JF,Boonme P,Garcia ML,Silva AM,Naveros BC,Souto EB

更新日期：2019-06-01 00:00:00

abstract：:Mefenamic acid (MA), a poorly water-soluble drug, was used as a model substance to investigate granules and tablet characteristics to be optimized for the loading volume of MA (0-74.1% v/v) in the formulation including lactose monohydrate/maize starch (7/3) as excipients. The compactibility of granules increased with ...

journal_title：Pharmaceutical development and technology

authors： Kimura G,Betz G,Leuenberger H

更新日期：2008-01-01 00:00:00