Formulation strategy of nitrofurantoin: co-crystal or solid dispersion?

abstract：:Elderly people, children and patients sometimes have difficulties swallowing tablets. To solve this problem, a novel method of preparing tablets that disintegrate rapidly in the mouth was developed. A tablet with high porosity is required for rapid disintegration, but such a tablet is generally fragile. To make a tabl...

journal_title：Pharmaceutical development and technology

authors： Sugimoto M,Matsubara K,Koida Y,Kobayashi M

更新日期：2001-11-01 00:00:00

abstract：:In this study, we developed a one-step method to prepare ibuprofen fast- and sustained-release complex preparation. It was based on a double jets electrospinning process. Ibuprofen, a poorly water-soluble drug, was electrospun into fibers with polyvinyl pyrrolidone and hydroxypropyl methyl cellulose by two jets, respe...

journal_title：Pharmaceutical development and technology

authors： Che X,Xue J,Zhang J,Yang X,Wang L

更新日期：2020-07-01 00:00:00

abstract：:The investigation was aimed at developing thermodynamically stable topical delivery system of nanostructured lipid carrier of econazole nitrate (EN) for the treatment of deep seated fungal infection by improving its permeability. Fifteen formulations (F1-F15) of nanostructured lipid carriers (NLCs) were prepared by so...

journal_title：Pharmaceutical development and technology

authors： Keshri L,Pathak K

更新日期：2013-05-01 00:00:00

abstract：:The biopharmaceutical assessment of new drug candidates based on their chemical structure is important in drug discovery and development. The scope of this study is to focus on lipophilic drugs and to clarify the role of their chemical predictors on oral bioavailability in humans. First their chemical properties were ...

journal_title：Pharmaceutical development and technology

authors： Kuentz MT,Arnold Y

更新日期：2009-01-01 00:00:00

abstract：:The aim of this work is to evaluate the feasibility of hydrophilic silica aerogels as drug carriers and to investigate the influence of the aerogels properties on the release rate of poorly water-soluble drugs. Hydrophilic silica aerogels of different densities were loaded with two model drugs, ketoprofen and griseofu...

journal_title：Pharmaceutical development and technology

authors： Smirnova I,Suttiruengwong S,Seiler M,Arlt W

更新日期：2004-11-01 00:00:00

abstract：:The purpose of this study was to develop a benchtop apparatus to simulate the scale-up of the moist-heat sterilization process of sodium carboxymethylcellulose (CMC) gel and identify critical process parameters that affect the sterilized gel viscosity. A 600-ml benchtop Parr reactor was modified and used to achieve go...

journal_title：Pharmaceutical development and technology

authors： Chu PI,Doyle D

更新日期：1999-01-01 00:00:00

abstract：:This study examines the influence of off-bottom clearance on size and size distribution of pellets produced during melt pelletization at different postmelt impeller speeds and binder concentrations using lactose and polyethylene glycol. Melt pelletization of lactose powder 450 M in an 8-liter highshear mixer, the floo...

journal_title：Pharmaceutical development and technology

authors： Heng PW,Wan LS,Wong TW

更新日期：1999-01-01 00:00:00

abstract：:Aluminum hydroxide adjuvant was pretreated with six concentrations of potassium dihydrogen phosphate to produce a series of adjuvants with various degrees of phosphate substitution for surface hydroxyl. The adsorption of three phosphorylated proteins (alpha casein, dephosphorylated alpha casein, and ovalbumin) by the ...

journal_title：Pharmaceutical development and technology

authors： Iyer S,HogenEsch H,Hem SL

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Oxaliplatin has long been used for the treatment of colorectal cancer via intra-venous infusion. In order to improve patient compliance, a solid dosage form for oral administration of oxaliplatin was prepared as nano-sized particles. METHOD:Nano oxaliplatin was prepared employing Fat Employing Supercritical...

journal_title：Pharmaceutical development and technology

authors： Lee SJ,Kim YH,Lee SH,Hahn M

更新日期：2012-03-01 00:00:00

abstract：CONTEXT AND OBJECTIVE:The objective of the study was to develop a stable capsule formulation of ziprasidone hydrochloride which can be administered without regards to food intake. MATERIALS AND METHODS:The unstable anhydrous form of ziprasidone hydrochloride was stabilized employing hot-melt extrusion and further opti...

journal_title：Pharmaceutical development and technology

authors： Banerjee S,Shankar KR,Prasad Y R

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:The purpose of this study is to investigate the mechanisms and thermodynamics of the interaction between hydroxypropyl beta-cyclodextrin (HPdetaCD) and [D-Trp6, des-Gly10] LHRH ethylamide (deslorelin), a peptide drug. METHODS:We used UV and fluorescence spectroscopy to study the interaction of HPbetaCD and des...

journal_title：Pharmaceutical development and technology

authors： Koushik KN,Bandi N,Kompella UB

更新日期：2001-11-01 00:00:00

abstract：:Mechanically generated radicals were shown to affect short-term stability of a model pharmaceutical formulation during high-shear processing. A formulation containing an oxidatively sensitive drug, either amorphous or crystalline, and a polymeric excipient was high-shear mixed and the resulting short-term degradation ...

journal_title：Pharmaceutical development and technology

authors： Polizzi MA,Singhal D,Colvin J

更新日期：2008-01-01 00:00:00

abstract：:The binding mechanism of tablets prepared by single-step granulation/tabletting (SSGT), a novel technique for the production of tablets, was evaluated. SSGT yielded hard tablets having a short disintegration time due to their porous, spongelike internal structure. Calculation of the interaction factor and electrical c...

journal_title：Pharmaceutical development and technology

authors： Vermeire A,Keleb EI,Kiekens F,Van Driessche I,Hoste S,Remon JP,Vervaet C

更新日期：2005-01-01 00:00:00

abstract：:This work aimed to incorporate Dexibuprofen (DXI), the pharmacologically active and more potent form of ibuprofen, into polymeric micelles based tablets with enhanced oral bioavailability. Thin film hydration technique was employed to prepare DXI polymeric micelles using Pluronic® F127 and/or P123 solutions in differe...

journal_title：Pharmaceutical development and technology

authors： Abdelbary G,Makhlouf A

更新日期：2014-09-01 00:00:00

abstract：:Hypericin (Hyp), a natural hydrophobic and photoactive pigment, and methylene blue (MB), a hydrophilic cationic dye, are utilized as photosensitizer (PS) for photodynamic therapy of cancer. Bioadhesive and thermoresponsive polymeric systems can improve the drug availability by increasing the contact time between the s...

journal_title：Pharmaceutical development and technology

authors： Borghi-Pangoni FB,Junqueira MV,Bruschi ML

更新日期：2020-04-01 00:00:00

abstract：:The main objective of this study was to design positively charged Levofloxacin Hemihydrate (Levo-h)-loaded nanoparticles with improved entrapment efficiency and antibacterial activity. PLGA alone or in combinations with Eudragit® RLPO or RS30D with or without positively charged inducing agent; 1,2-dioleoyl-3-trimethyl...

journal_title：Pharmaceutical development and technology

authors： Hasan AA,Sabry SA,Abdallah MH,El-Damasy DA

更新日期：2016-09-01 00:00:00

abstract：:16-Dehydropregnenolone (16-DHP) is an active compound with an unsatisfied in vivo behavior and poor water-solubility, which limits its clinical application. To improve its in vivo behavior and water-solubility, a Hydroxypropyl-beta-Cyclodextrin (HP-β-CD) inclusion complex of 16-DHP was prepared in this paper. Pharmaco...

journal_title：Pharmaceutical development and technology

authors： Sun Y,Jia L,Zhou H,Mao M,Wang X,Wei L,Sun L

更新日期：2017-03-01 00:00:00

abstract：:The objective of the present work is to investigate the presence or absence of a critical concentration of maize starch according to the percolation theory for a truly ternary system with respect to a minimum disintegration time. The results of this study show that the application of percolation theory is not limited ...

journal_title：Pharmaceutical development and technology

authors： Kimura G,Puchkov M,Betz G,Leuenberger H

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Aerodynamically stable, nebulized aerosols are desirable to achieve optimum asthma therapy. Stabilizing droplet size using gel-forming polymers may assist in achieving this goal. Semisolid particles may be generated through aerosolization of a polymer solution. Gelatin was employed as a model polymer in a proce...

journal_title：Pharmaceutical development and technology

authors： Deaton AT,Jones LD,Dunbar CA,Hickey AJ,Williams DM

更新日期：2002-05-01 00:00:00

abstract：:The key for better antitumor efficacy is to improve the specificity of antitumor drugs for tumor cells and diminish their cytotoxicity to normal tissues. Targeted nanoparticles as antitumor drug delivery system can resolve this problem. In this study, we prepared folate and TAT (arginine-rich cell-penetrating peptide)...

journal_title：Pharmaceutical development and technology

authors： Zhang S,Liu Y,Gan Y,Qiu N,Gu Y,Zhu H

更新日期：2019-02-01 00:00:00

abstract：:Magnesium stearate (MgSt) is a widely used pharmaceutical lubricant in tablet manufacturing. However, batch-to-batch variability in hydrate form and surface area can lead to inconsistency in tablet performance. In this work, several unique MgSt samples were studied: traditional monohydrate samples with high surface ar...

journal_title：Pharmaceutical development and technology

authors： Calahan JL,Paul S,Yanez EG,DeNeve D,Sun CC,Munson EJ

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:BMS-196843 (Oncostatin M) is a therapeutic recombinant protein in development. Scale-up process changes led to unexpected instability of the bulk drug substance solution during storage. A product with an apparent higher MW than the parent protein was observed by the size-exclusion chromatography (SEC). This stu...

journal_title：Pharmaceutical development and technology

authors： Zhao F,Stein DJ,Paborji M,Cash PW,Root BJ,Wei Z,Knupp CJ

更新日期：2001-01-01 00:00:00

abstract：:The objective of this study was to compare the dissolution behavior of tablets prepared from solid dispersions with and without drug-carrier interactions. Diazepam and nifedipine were used as model drugs. Two types of carriers were used; polyvinylpyrrolidone (PVP K12, K30 and K60) and saccharides (inulin 1.8 kDa, 4 kD...

journal_title：Pharmaceutical development and technology

authors： Srinarong P,Kouwen S,Visser MR,Hinrichs WL,Frijlink HW

更新日期：2010-09-01 00:00:00

abstract：:Due to their light consistency and good spreadability, aqueous foams are considered as convenient and highly accepted drug carrier systems that are of great importance in the field of topical drug delivery. The production of a stable, easy to dose, preferably environmentally harmless foam formulation is challenging. T...

journal_title：Pharmaceutical development and technology

authors： Farkas D,Kállai-Szabó N,Sárádi-Kesztyűs Á,Lengyel M,Magramane S,Kiss É,Antal I

更新日期：2020-12-27 00:00:00

abstract：:In the present study, Simvastatin was incorporated in emulsion of soybean oil and propylene glycol monocaprylate as oily phase and Tween 80 and Cremophor EL as surfactants and also their mixtures. Dry adsorbed emulsions were prepared by using colloidal silicon dioxide in varying proportions to adsorb the liquid emulsi...

journal_title：Pharmaceutical development and technology

authors： Dixit RP,Nagarsenker MS

更新日期：2007-01-01 00:00:00

abstract：:Nucleic acids therapeutic efficiency is generally limited by their low stability and intracellular bioavailability, and by the toxicity of the carriers used to deliver them to the target sites. Aminated poly(glycerol methacrylate) polymers are biodegradable and pH-sensitive polymers that have been used previously to d...

journal_title：Pharmaceutical development and technology

authors： Morsi NG,Ali SM,Elsonbaty SS,Afifi AA,Hamad MA,Gao H,Elsabahy M

更新日期：2018-04-01 00:00:00

abstract：:A redox-responsive docetaxel (DTX) prodrug consisting of a disulfide linkage between DTX and vitamin E (DTX-SS-VE) was synthesized in our laboratory and was successfully formulated into liposomes. The aim of this study was to optimize the formulation and investigate the cellular uptake of DTX prodrug-loaded liposomes ...

journal_title：Pharmaceutical development and technology

authors： Ren G,Jiang M,Guo W,Sun B,Lian H,Wang Y,He Z

更新日期：2018-01-01 00:00:00

abstract：:A comprehensive analytical solution that accounts for many factors and assumptions affecting drug concentration profile in the gastrointestinal tract was presented. A sensitivity analysis approach was utilized in order to investigate the importance of different parameters in the model. The partition coefficient is fou...

journal_title：Pharmaceutical development and technology

authors： Idkaidek NM,Abdel-Jabbar N

更新日期：2001-01-01 00:00:00

abstract：:Drug-excipient compatibility studies lay the foundation for designing a chemically stable formulation for clinical and commercial development. This article describes the investigation of oxidative degradation encountered with compound A (a phenylalanine-drug complex) in a capsule dosage form. Two wet- granulation caps...

journal_title：Pharmaceutical development and technology

authors： Wu Y,Dali M,Gupta A,Raghavan K

更新日期：2009-01-01 00:00:00

abstract：:A novel analytical procedure has been developed for quantitative determination of levodopa and carbidopa in aqueous binary solutions acidified by HCl and without any other sample pretreatment. The method is based partially on least squares treatment of data obtained by attenuated total reflectance Fourier transform in...

journal_title：Pharmaceutical development and technology

authors： Khanmohammadi M,Mobedi E,Garmarudi AB,Mobedi H,Kargosha K

更新日期：2007-01-01 00:00:00