Abstract:
:Ternary complexes of meloxicam (ML), a poorly water-soluble anti-inflammatory drug, with β-cyclodextrin (βCD) and polyethylene glycol (PEG) 6000 were prepared from an equimolar (ML-βCD) and 10% of PEG. Characterization of the ternary complex was carried out by differential scanning calorimetry and X-ray diffractometry. The solubility of ML increased as a function of increasing the concentration of βCD and PEG 6000. Ternary system increased significantly ML solubility in water. Ternary complexes improved drug release compared with ML and ML-βCD. The oral bioavailability of ML-βCD-PEG was investigated by administration to rat and compared with ML and ML-βCD. The results confirmed that the oral bioavailability of ML was significantly improved by complexation with βCD in the presence of PEG.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Radia O,Rogalska E,Moulay-Hassane Gdoi
10.3109/10837450.2011.565347subject
Has Abstractpub_date
2012-09-01 00:00:00pages
632-7issue
5eissn
1083-7450issn
1097-9867journal_volume
17pub_type
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journal_title:Pharmaceutical development and technology
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