Novel buccal adhesive system for anti-hypertensive agent nimodipine.

abstract：:The objective of the present investigation was to enhance skin permeation of diclofenac using water-in-oil microemulsion and to elucidate its skin permeation mechanism. The w/o microemulsion formulations were selected based on constructed pseudoternary phase diagrams depending on water solubilization capacity and ther...

journal_title：Pharmaceutical development and technology

authors： Thakkar PJ,Madan P,Lin S

更新日期：2014-05-01 00:00:00

abstract：:The objective of this investigation was to formulate ocular inserts of gatifloxacin sesquehydrate to achieve controlled drug release. Drug reservoir was prepared using hydrophilic polymers, namely polyvinyl alcohol and polyvinyl pyrrolidone. The rate controlling membrane was prepared using hydrophobic ethyl cellulose ...

journal_title：Pharmaceutical development and technology

authors： Patel UL,Chotai NP,Nagda CD

更新日期：2012-01-01 00:00:00

abstract：:The instability of protein and antigen(s) during encapsulation in biodegradable polymers by water-in-oil-in-water (w/o/w) encapsulation is well established. The aim of present study is to screen various additives to prevent the inactivation and loss of immunogenicity of HBsAg upon its exposure to the water/CH(2)Cl(2) ...

journal_title：Pharmaceutical development and technology

authors： Tomar P,Giri N,Karwasara VS,Pandey RS,Dixit VK

更新日期：2012-07-01 00:00:00

abstract：:A new approach to developing a drug-polymer mixed coat for highly water-soluble diltiazem pellets was investigated at different coating levels. Drug layering and the coating procedures were performed using a bottom spray fluidized bed coater. Drug pellets were coated with Eudragit NE40 (NE40) alone and in combination ...

journal_title：Pharmaceutical development and technology

authors： Nisar ur Rahman,Yuen KH,Khan NA,Wong JW

更新日期：2006-02-01 00:00:00

abstract：:The biopharmaceutical assessment of new drug candidates based on their chemical structure is important in drug discovery and development. The scope of this study is to focus on lipophilic drugs and to clarify the role of their chemical predictors on oral bioavailability in humans. First their chemical properties were ...

journal_title：Pharmaceutical development and technology

authors： Kuentz MT,Arnold Y

更新日期：2009-01-01 00:00:00

abstract：:The present work investigated the magnitude of microsphere-induced acute myotoxicity and determined whether this myotoxicity is related to microsphere size and/or reconstitution solvent. Using a high molecular weight poly(dl-lactide-co-glycolide) copolymer, the myotoxicity of two different size microsphere formulation...

journal_title：Pharmaceutical development and technology

authors： Brazeau GA,Sciame M,al-Suwayeh SA,Fattal E

更新日期：1996-10-01 00:00:00

abstract：:New microspheres containing hydrophilic core and hydrophobic coating as a controlled-release system with no toxic reagents were proposed. Water in oil in water (W/O/W) emulsion and solvent evaporation methods were used to make chitosan/ cellulose acetate (CCA) microspheres sized 200 - 400 microm. Ranitidine hydrochlor...

journal_title：Pharmaceutical development and technology

authors： Zhou HY,Chen XG,Liu CS,Meng XH,Yu LJ,Liu XY,Liu N

更新日期：2005-01-01 00:00:00

abstract：:Understanding variability in excipient physico-chemical properties is becoming an important aspect of Quality-by-Design drug product development. However, present experimental methods have only been able to study a few physico-chemical properties for a few excipient lots due to time, cost, and sample gathering conside...

journal_title：Pharmaceutical development and technology

authors： Kushner J 4th

更新日期：2013-03-01 00:00:00

abstract：:Elderly people, children and patients sometimes have difficulties swallowing tablets. To solve this problem, a novel method of preparing tablets that disintegrate rapidly in the mouth was developed. A tablet with high porosity is required for rapid disintegration, but such a tablet is generally fragile. To make a tabl...

journal_title：Pharmaceutical development and technology

authors： Sugimoto M,Matsubara K,Koida Y,Kobayashi M

更新日期：2001-11-01 00:00:00

abstract：:Pulmonary delivery of peptides remains an important, noninvasive route of administration that is attractive because it offers high bioavailability and patient compliance. Optimization of particle characteristics for deposition in the deep regions of the lung after inhalation and retention of peptide stability are key ...

journal_title：Pharmaceutical development and technology

authors： Poursina N,Vatanara A,Rouini MR,Gilani K,Rouholamini Najafabadi A

更新日期：2017-09-01 00:00:00

abstract：:Poor solubility and bioavailability of drugs are often affected by its microscopic structural properties. Nitrofurantoin (NF), a Biopharmaceutics Classification System class II item, has a low water solubility with low plasma concentrations. To improve its therapeutic efficacy, formulation strategy of solid dispersion...

journal_title：Pharmaceutical development and technology

authors： Teoh XY,Bt Mahyuddin FN,Ahmad W,Chan SY

更新日期：2020-02-01 00:00:00

abstract：:Mucosa has now been recognized as a potential site for both local and systemic delivery of therapeutics. Mucoadhesive drug delivery systems with customizable release profiles have recently gained considerable interest among formulation scientists to improve clinical outcomes of drugs. This review summarizes the curren...

journal_title：Pharmaceutical development and technology

authors： Kumar A,Naik PK,Pradhan D,Ghosh G,Rath G

更新日期：2020-09-01 00:00:00

abstract：:Two types of casein hydrolysates, casein A (mean peptide length 3.3) and casein B (mean peptide length 17.4) were prepared by the enzymatic hydrolysis of casein, and their effects on in vitro dissolution rates and oral bioavailability of drugs were evaluated. The in vitro dissolution behavior of the kneaded mixture of...

journal_title：Pharmaceutical development and technology

authors： Imai T,Nishiyama T,Shameem M,Otagiri M

更新日期：1998-05-01 00:00:00

abstract：:Bupivacaine lipid microparticles were prepared and evaluated as a parenteral sustained-release dosage form for postoperative pain management. Bupivacaine free base was incorporated into a molten tristearin matrix and lipid micro-particles were subsequently formed from this molten mixture by a spray-congealing process....

journal_title：Pharmaceutical development and technology

authors： Li LC,Zhu L,Song JF,Deng JS,Bandopadhyay R,Wurster DE

更新日期：2005-01-01 00:00:00

abstract：:Alendronate sodium (ALD) is a bisphosphonate medication used in the treatment and prevention of osteoporosis. Absorption of ALD as oral formulation is very poor (0.5%-1%). Its bioavailability can decrease with food effect. It has some gastrointestinal adverse effects such as gastritis, gastric ulcer, and esophagitis. ...

journal_title：Pharmaceutical development and technology

authors： Asikoğlu M,Ozguney I,Ozcan I,Orumlu O,Guneri T,Koseoğlu K,Ozkilic H

更新日期：2008-01-01 00:00:00

abstract：:A preliminary study of the feasibility of using near-infrared spectroscopy (NIRS) for the offline simultaneous determination of metoprolol tartrate (MTP) and hydrochlorothiazide (HTZ) in powders and tablets has been carried out. An industrial tableting process was simulated using an instrumented tablet press replicato...

journal_title：Pharmaceutical development and technology

authors： Vranic BZ,Vandamme TF

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Oxaliplatin has long been used for the treatment of colorectal cancer via intra-venous infusion. In order to improve patient compliance, a solid dosage form for oral administration of oxaliplatin was prepared as nano-sized particles. METHOD:Nano oxaliplatin was prepared employing Fat Employing Supercritical...

journal_title：Pharmaceutical development and technology

authors： Lee SJ,Kim YH,Lee SH,Hahn M

更新日期：2012-03-01 00:00:00

abstract：:The objective of this study was to prepare pellets of thyme (Thymus vulgaris L.), stinging nettle (Urtica dioica L.) and sage (Salvia officinalis L.) dry extracts by extrusion-spheronization technique to improve technological properties and investigate dissolution profiles of pellets covered different levels of pH-sen...

journal_title：Pharmaceutical development and technology

authors： Kaledaite R,Bernatoniene J,Dvořáčková K,Gajdziok J,Muselík J,Pečiūra R,Masteikova R

更新日期：2015-11-01 00:00:00

abstract：CONTEXT:Development and evaluation of thermosensitive and bioadhesive liquid suppositories containing ketoprofen (KP). OBJECTIVE:This study was conducted to develope thermosensitive and bioadhesive liquid suppositories containing KP using poloxamer and different bioadhesive polymers and to investigate their gelation t...

journal_title：Pharmaceutical development and technology

authors： Ozgüney I,Kardhiqi A

更新日期：2014-12-01 00:00:00

abstract：:The objective of this study was to compare the dissolution behavior of tablets prepared from solid dispersions with and without drug-carrier interactions. Diazepam and nifedipine were used as model drugs. Two types of carriers were used; polyvinylpyrrolidone (PVP K12, K30 and K60) and saccharides (inulin 1.8 kDa, 4 kD...

journal_title：Pharmaceutical development and technology

authors： Srinarong P,Kouwen S,Visser MR,Hinrichs WL,Frijlink HW

更新日期：2010-09-01 00:00:00

abstract：:Oily liquid drugs are not convenient for oral administration. We developed a powder containing clofibrate (CF), a model of an oily drug, using aminoalkyl methacrylate copolymer (EPO) or methacrylic acid copolymer (L100). CF or a mixture of CF and soybean oil was emulsified with EPO or L100 aqueous solution. Using a hi...

journal_title：Pharmaceutical development and technology

authors： Fujii M,Kawakami A,Saito A,Tuchiya H,Koizumi N,Watanabe Y

更新日期：2016-12-01 00:00:00

abstract：:This study examines the effect of the degree of methoxylation (DM) and particle size on compression properties and compactibility of pectin powders. A powder classification system based on sequential handling of compression parameters was applied. A single size fraction (90-125 μm) of pectin powders with DM values ran...

journal_title：Pharmaceutical development and technology

authors： Salbu L,Bauer-Brandl A,Alderborn G,Tho I

更新日期：2012-05-01 00:00:00

abstract：:In the current study, the influence of chitosan on the dissolution rate and bioavailability of acyclovir has been illustrated through the preparation of co-crystals by simple solvent change method. Chitosan was precipitated on acyclovir crystals using sodium citrate as the salting out agent. The pure drug and the prep...

journal_title：Pharmaceutical development and technology

authors： Allam AN,Naggar VF,El Gamal SS

更新日期：2013-07-01 00:00:00

abstract：:The objective of this paper was to evaluate the mucoadhesive and sustained-release properties of the water-soluble gum obtained from Hakea gibbosa (hakea), for the formulation of buccal tablets. Flatfaced tablets containing hakea were formulated using chlorpheniramine maleate (CPM) as a model drug. Two types of tablet...

journal_title：Pharmaceutical development and technology

authors： Alur HH,Pather SI,Mitra AK,Johnston TP

更新日期：1999-08-01 00:00:00

abstract：:The main objective of this research is to use the near-infrared diffuse reflectance method to evaluate and quantify the effects of hardness and porosity on the near-infrared spectras of tablets. To develop a model equation, validate the model and test the model predictive ability. Seven theophylline tablet formulation...

journal_title：Pharmaceutical development and technology

authors： Donoso M,Kildsig DO,Ghaly ES

更新日期：2003-01-01 00:00:00

abstract：:The principal purpose of the present study was to prepare and characterize a complex drug delivery system consisting of Nafarelin-poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) in combination with sodium alginate/poloxamer 407 in situ gel. Nafarelin-loaded PHBV NPs were prepared via double em...

journal_title：Pharmaceutical development and technology

authors： Alizadeh B,Bahari Javan N,Akbari Javar H,Khoshayand MR,Dorkoosh F

更新日期：2018-02-01 00:00:00

abstract：:A comprehensive analytical solution that accounts for many factors and assumptions affecting drug concentration profile in the gastrointestinal tract was presented. A sensitivity analysis approach was utilized in order to investigate the importance of different parameters in the model. The partition coefficient is fou...

journal_title：Pharmaceutical development and technology

authors： Idkaidek NM,Abdel-Jabbar N

更新日期：2001-01-01 00:00:00

abstract：:The present study was carried out in order to mask the bitter taste of the Etoricoxib by complexation with cation-exchange resin, Indion 204. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 mi...

journal_title：Pharmaceutical development and technology

authors： Patra S,Samantaray R,Pattnaik S,Barik BB

更新日期：2010-09-01 00:00:00

abstract：:A novel flavonoid-polysaccharide conjugate was synthesized by free radical grafting of quercetin on starch. The covalent insertion of quercetin in the polymeric chain was confirmed by FT-IR, DSC and fluorescence analyses, while an estimation of the amount of quercetin bound per g of polymer was obtained by the Folin-C...

journal_title：Pharmaceutical development and technology

authors： Cirillo G,Puoci F,Iemma F,Curcio M,Parisi OI,Spizzirri UG,Altimari I,Picci N

更新日期：2012-07-01 00:00:00

abstract：:Novel fast-disintegrating multi-unit tablets (FDMUTs) were prepared to modify the release of lornoxicam (a potent non-steroidal anti-inflammatory drug with a short half-life) as well as to combine the advantages of multi-unit systems with the cost-effectiveness of compressed tablets. The proposed FDMUTs consisted of s...

journal_title：Pharmaceutical development and technology

authors： Aburahma MH,Hamza Yel-S

更新日期：2011-08-01 00:00:00