Preparation, preliminary pharmacokinetics and brain tissue distribution of Tanshinone IIA and Tetramethylpyrazine composite nanoemulsions.

abstract：:Fixed dose combination (FDC) products are common in the treatment of hypertension, diabetes, human immunodeficiency virus, and tuberculosis. They make it possible to combine two or more drug molecules with different modes of pharmacological actions in a single dosing unit and optimize the treatment. From a patient per...

journal_title：Pharmaceutical development and technology

authors： Desai D,Wang J,Wen H,Li X,Timmins P

更新日期：2013-11-01 00:00:00

abstract：:The effect of six factors: spray gun, formulation, inlet temperature, atomizing air pressure, fan air pressure, and gun-bed distance, on the final adhesion of the film coat to the tablet core were assessed. The method used was based on an experimental design, Resolution IV, that allowed the main effects to be free fro...

journal_title：Pharmaceutical development and technology

authors： Khan H,Fell JT,Macleod GS

更新日期：2005-01-01 00:00:00

abstract：:The objective of this study was to investigate the effect of the physiological parameters (pH, buffer capacity, and ionic strength) of the gastrointestinal (GI) fluid on the dissolution behavior of the class II weakly acidic (BCS class IIa) drug valsartan. A series of in vitro dissolution studies was carried out on Di...

journal_title：Pharmaceutical development and technology

authors： Hamed R

更新日期：2018-12-01 00:00:00

abstract：:The main objective of the present study was to improve bioavailability of diltiazem hydrochloride and decrease the frequency of dosage form administration by increasing the encapsulation efficiency of the drug, residence time of the dosage form at the site of absorption and sustained release of the drug from the deliv...

journal_title：Pharmaceutical development and technology

authors： Sultana Y,Mall S,Maurya DP,Kumar D,Das M

更新日期：2009-01-01 00:00:00

abstract：:Poor solubility and bioavailability of drugs are often affected by its microscopic structural properties. Nitrofurantoin (NF), a Biopharmaceutics Classification System class II item, has a low water solubility with low plasma concentrations. To improve its therapeutic efficacy, formulation strategy of solid dispersion...

journal_title：Pharmaceutical development and technology

authors： Teoh XY,Bt Mahyuddin FN,Ahmad W,Chan SY

更新日期：2020-02-01 00:00:00

abstract：:Letrozole (LTZ), an aromatase inhibitor used for the treatment of hormonally-positive breast cancer in postmenopausal women, has poor water solubility, rapid metabolism, and a range of side effects. In this study, polymer-based nanoparticles (NPs) incorporating the drug have been designed and characterized, aimed to c...

journal_title：Pharmaceutical development and technology

authors： Alemrayat B,Elhissi A,Younes HM

更新日期：2019-02-01 00:00:00

abstract：:The purpose of this study was to develop a method to prepare Metoprolol Succinate (MS) sustained release pellets and compress them into pellet-containing tablets without losing sustained release property. The drug layered pellets were coated with Eudragit NE 30D to obtain a sustained release (SR) property. The mechani...

journal_title：Pharmaceutical development and technology

authors： Yang Z,Yu J,Yang T,Xing H,Zhang J,Xian L,Ding P,Wang D

更新日期：2016-12-01 00:00:00

abstract：:Co-solvent solubilization approach has been used to enhance the solubility of seven antidiabetic drugs: gliclazide, glyburide, glipizide, glimepiride, repaglinide, pioglitazone, and roziglitazone. Solubility in water, phosphate buffer (pH 7.4), six co-solvent solutions prepared in water as well as phosphate buffer (pH...

journal_title：Pharmaceutical development and technology

authors： Seedher N,Kanojia M

更新日期：2009-01-01 00:00:00

abstract：:The dry coating process was evaluated in terms of storage stability investigating drug release and agglomeration tendency of the different coated oral dosage forms; hydroxypropyl methylcellulose acetate succinate (HPMCAS) was used with triethylcitrate (TEC) as plasticizer and acetylated monoglyceride (Myvacet) as wett...

journal_title：Pharmaceutical development and technology

authors： Kablitz CD,Urbanetz NA

更新日期：2009-01-01 00:00:00

abstract：:Preterm labor is the main cause of death and serious illness of both infants and pregnant women in Africa and worldwide. Parenteral and oral salbutamol sulfate as a B2 antagonist has been used for the treatment of preterm labor. The study aims are to formulate salbutamol sulfate non-invasive vaginal bioadhesive tablet...

journal_title：Pharmaceutical development and technology

authors： El-Enin ASMA,Elbakry AM,Hosary RE,Lotfy MAF

更新日期：2020-10-01 00:00:00

abstract：:Effects of various factors, such as light intensity, polarizability of n-alcohol solvents, addition of colorants, and viscosity of solutions on the kinetics of the photoisomerization of therapeutically effective E-isomer of sorivudine to its less effective Z-isomer were studied. Solutions of known concentrations of E-...

journal_title：Pharmaceutical development and technology

authors： Desai D,Li D,Janjikhel R,Lang B,Jain N

更新日期：2001-01-01 00:00:00

abstract：CONTEXT:Teicoplanin is a glycopeptide antibiotic consisting of a combination of different active components. Clinical equivalence between different batches of this drug is not guaranteed by the present pharmacopeial specification of chemical composition based on an HPLC chromatogram. OBJECTIVE:To test a modification o...

journal_title：Pharmaceutical development and technology

authors： Boix-Montañes A,Garcia-Arieta A

更新日期：2016-08-01 00:00:00

abstract：:The purpose of this study was to develop a benchtop apparatus to simulate the scale-up of the moist-heat sterilization process of sodium carboxymethylcellulose (CMC) gel and identify critical process parameters that affect the sterilized gel viscosity. A 600-ml benchtop Parr reactor was modified and used to achieve go...

journal_title：Pharmaceutical development and technology

authors： Chu PI,Doyle D

更新日期：1999-01-01 00:00:00

abstract：:The aim of this study was to prepare a highly porous multiparticulate dosage form containing cilostazol for gastroretentive drug delivery. The floating pellets were prepared with glyceryl behenate as a matrix former and camphor as a sublimating agent by extrusion/spheronization and sublimation under vacuum. Granules p...

journal_title：Pharmaceutical development and technology

authors： Hwang KM,Byun W,Cho CH,Park ES

更新日期：2018-06-01 00:00:00

abstract：:Alpha lipoic acid (ALA), an active substance in anti-aging products and dietary supplements, need to be masked with an edible polymer to obscure its unpleasant taste. However, the high viscosity of the ALA molecules prevents them from forming microcomposites with masking materials even in supercritical carbon dioxide ...

journal_title：Pharmaceutical development and technology

authors： Mishima K,Honjo M,Sharmin T,Ito S,Kawakami R,Kato T,Misumi M,Suetsugu T,Orii H,Kawano H,Irie K,Sano K,Mishima K,Harada T,Ouchi M

更新日期：2016-09-01 00:00:00

abstract：:16-Dehydropregnenolone (16-DHP) is an active compound with an unsatisfied in vivo behavior and poor water-solubility, which limits its clinical application. To improve its in vivo behavior and water-solubility, a Hydroxypropyl-beta-Cyclodextrin (HP-β-CD) inclusion complex of 16-DHP was prepared in this paper. Pharmaco...

journal_title：Pharmaceutical development and technology

authors： Sun Y,Jia L,Zhou H,Mao M,Wang X,Wei L,Sun L

更新日期：2017-03-01 00:00:00

abstract：:Drug-excipient compatibility studies lay the foundation for designing a chemically stable formulation for clinical and commercial development. This article describes the investigation of oxidative degradation encountered with compound A (a phenylalanine-drug complex) in a capsule dosage form. Two wet- granulation caps...

journal_title：Pharmaceutical development and technology

authors： Wu Y,Dali M,Gupta A,Raghavan K

更新日期：2009-01-01 00:00:00

abstract：:Flecainide base is pharmaceutically active substance used for production of flecainide acetate which is known in market as Tambacor, Almarytm, Apocard, Ecrinal or Flecaine. It is determined that flecainide base forms four polymorphic forms abbreviated as Ib, IIb, IIIb and IVb. Flecainide base form Ib is thermodynamica...

journal_title：Pharmaceutical development and technology

authors： Veldre K,Eglīte Z,Actiņš A,Zvirgzdiņš A,Rozenberga L,Tamanis E

更新日期：2014-02-01 00:00:00

abstract：:This study reports on the impact of cyclodextrin addition on the phase behavior of microemulsion systems. Three distinct oil-in-water microemulsions were formulated and subjected to increasing concentrations of various cyclodextrins. The prepared formulations underwent visual, textural and microscopic characterization...

journal_title：Pharmaceutical development and technology

authors： Thakur SS,Solloway J,Stikkelman A,Seyfoddin A,Rupenthal ID

更新日期：2018-02-01 00:00:00

abstract：:The present study was aimed to develop a matrix-type transdermal formulation of pentazocine using mixed polymeric grades of Eudragit RL/RS. The possible interaction between drug and polymer used were characterized by FTIR, DSC and X-RD. X-RD study indicates a change of state of drug from crystalline to amorphous in th...

journal_title：Pharmaceutical development and technology

authors： Chandak AR,Prasad Verma PR

更新日期：2010-06-01 00:00:00

abstract：:The present study was carried out in order to mask the bitter taste of the Etoricoxib by complexation with cation-exchange resin, Indion 204. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 mi...

journal_title：Pharmaceutical development and technology

authors： Patra S,Samantaray R,Pattnaik S,Barik BB

更新日期：2010-09-01 00:00:00

abstract：:In this study, we developed a one-step method to prepare ibuprofen fast- and sustained-release complex preparation. It was based on a double jets electrospinning process. Ibuprofen, a poorly water-soluble drug, was electrospun into fibers with polyvinyl pyrrolidone and hydroxypropyl methyl cellulose by two jets, respe...

journal_title：Pharmaceutical development and technology

authors： Che X,Xue J,Zhang J,Yang X,Wang L

更新日期：2020-07-01 00:00:00

abstract：:The aim of the present study is to prepare risperidone-loaded poly lactic-co-glycolic acid (PLGA) microspheres within microfluidic system and to achieve a formulation with uniform size and monotonic and reproducible release profile. In comparison to batch method, T-junction and serpentine chips were utilized and optim...

journal_title：Pharmaceutical development and technology

authors： Jafarifar E,Hajialyani M,Akbari M,Rahimi M,Shokoohinia Y,Fattahi A

更新日期：2017-09-01 00:00:00

abstract：:The purpose of this research was to design and develop a novel controlled-release bead formulation for oral administration with buffer crystals as a carrier for loading of fenoldopam mesylate, an intravenous antihypertensive agent, which provides an in vitro release rate of 30-50 mg/hr for 6-8 hr. Buffer crystals were...

journal_title：Pharmaceutical development and technology

authors： Venkatesh GM

更新日期：1998-11-01 00:00:00

abstract：:The objective of this investigation was to formulate ocular inserts of gatifloxacin sesquehydrate to achieve controlled drug release. Drug reservoir was prepared using hydrophilic polymers, namely polyvinyl alcohol and polyvinyl pyrrolidone. The rate controlling membrane was prepared using hydrophobic ethyl cellulose ...

journal_title：Pharmaceutical development and technology

authors： Patel UL,Chotai NP,Nagda CD

更新日期：2012-01-01 00:00:00

abstract：:The aim of the present investigation was to develop and study topical gel delivery of curcumin for its anti-inflammatory effects. Carbopol 934P (CRB) and hydroxypropylcellulose (HPC) were used for the preparation of gels. The penetration enhancing effect of menthol (0-12.5% w/w) on the percutaneous flux of curcumin th...

journal_title：Pharmaceutical development and technology

authors： Patel NA,Patel NJ,Patel RP

更新日期：2009-01-01 00:00:00

abstract：:A comprehensive analytical solution that accounts for many factors and assumptions affecting drug concentration profile in the gastrointestinal tract was presented. A sensitivity analysis approach was utilized in order to investigate the importance of different parameters in the model. The partition coefficient is fou...

journal_title：Pharmaceutical development and technology

authors： Idkaidek NM,Abdel-Jabbar N

更新日期：2001-01-01 00:00:00

abstract：:The physical stability of amorphous solid dispersions (SDs) is influenced by their storage conditions. The goal of this work was to investigate the factors affecting the recrystallization of drugs in SDs after storage under conditions of high temperature and high humidity. SDs of three drugs (dipyridamole, nifedipine ...

journal_title：Pharmaceutical development and technology

authors： Shibata Y,Fujii M,Suzuki A,Koizumi N,Kanada K,Yamada M,Watanabe Y

更新日期：2014-06-01 00:00:00

abstract：:This study explored the application of chitosan-alginate (CA) and chitosan-pectin (CP) complex films as drug release regulator for the preparation of multiunit controlled-release diclofenac sodium capsules. Pellets containing drug and microcrystalline cellulose, in a ratio of 3:5, were prepared in a fluidized rotary g...

journal_title：Pharmaceutical development and technology

authors： Mitrevej A,Sinchaipanid N,Rungvejhavuttivittaya Y,Kositchaiyong V

更新日期：2001-08-01 00:00:00

abstract：:The aim of this work is development of a nontoxic, long-term stable solid lipid nanoparticles (SLN) formulation for the loading of Nimesulide (NiM) by a 22 factorial design. The optimized formulation was composed of 10 wt% of glyceryl behenate and 2.5 wt% of poloxamer 188. Immediately after production, Z-Ave of NiM-SL...

journal_title：Pharmaceutical development and technology

authors： Campos JR,Fernandes AR,Sousa R,Fangueiro JF,Boonme P,Garcia ML,Silva AM,Naveros BC,Souto EB

更新日期：2019-06-01 00:00:00