Application of Design Expert for the investigation of capsaicin-loaded microemulsions for transdermal delivery.

abstract：:The purpose of this study was to investigate the effect of the composition of a binary powder mixture on the bonding index, the brittle fracture index, and the strain index, as defined by Hiestand. The studies involved tensile strength and dynamic indentation hardness determinations of square compacts, the solid fract...

journal_title：Pharmaceutical development and technology

authors： Majuru S,Wurster DE

更新日期：1997-11-01 00:00:00

abstract：:The aim of this study was to prepare electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats and to incorporate plai oil (Zingiber Cassumunar Roxb.). The plai oil with 10, 20 and 30% wt to polymer were incorporated in the PVP/HPβCD solution and electrospun to obtain nanofibers. The...

journal_title：Pharmaceutical development and technology

authors： Tonglairoum P,Chuchote T,Ngawhirunpat T,Rojanarata T,Opanasopit P

更新日期：2014-06-01 00:00:00

abstract：:This paper proposes the development of a drug product Manufacturing Classification System (MCS) based on processing route. It summarizes conclusions from a dedicated APS conference and subsequent discussion within APS focus groups and the MCS working party. The MCS is intended as a tool for pharmaceutical scientists t...

journal_title：Pharmaceutical development and technology

authors： Leane M,Pitt K,Reynolds G,Manufacturing Classification System (MCS) Working Group.

更新日期：2015-01-01 00:00:00

abstract：:The objective of this study was to prepare pellets of thyme (Thymus vulgaris L.), stinging nettle (Urtica dioica L.) and sage (Salvia officinalis L.) dry extracts by extrusion-spheronization technique to improve technological properties and investigate dissolution profiles of pellets covered different levels of pH-sen...

journal_title：Pharmaceutical development and technology

authors： Kaledaite R,Bernatoniene J,Dvořáčková K,Gajdziok J,Muselík J,Pečiūra R,Masteikova R

更新日期：2015-11-01 00:00:00

abstract：:Novel fast-disintegrating multi-unit tablets (FDMUTs) were prepared to modify the release of lornoxicam (a potent non-steroidal anti-inflammatory drug with a short half-life) as well as to combine the advantages of multi-unit systems with the cost-effectiveness of compressed tablets. The proposed FDMUTs consisted of s...

journal_title：Pharmaceutical development and technology

authors： Aburahma MH,Hamza Yel-S

更新日期：2011-08-01 00:00:00

abstract：:Co-solvent solubilization approach has been used to enhance the solubility of seven antidiabetic drugs: gliclazide, glyburide, glipizide, glimepiride, repaglinide, pioglitazone, and roziglitazone. Solubility in water, phosphate buffer (pH 7.4), six co-solvent solutions prepared in water as well as phosphate buffer (pH...

journal_title：Pharmaceutical development and technology

authors： Seedher N,Kanojia M

更新日期：2009-01-01 00:00:00

abstract：:Fixed dose combination (FDC) products are common in the treatment of hypertension, diabetes, human immunodeficiency virus, and tuberculosis. They make it possible to combine two or more drug molecules with different modes of pharmacological actions in a single dosing unit and optimize the treatment. From a patient per...

journal_title：Pharmaceutical development and technology

authors： Desai D,Wang J,Wen H,Li X,Timmins P

更新日期：2013-11-01 00:00:00

abstract：:When a nebulizer is evaluated by the Andersen Cascade Impactor (ACI), the flow rate is generally maintained at 28.3 L/min, as recommended by the manufacturer. However, the nebulizer flow rate that a patient inhales is only around 18 L/min. Because the drive flow of a nebulizer is approximately 6-8 L/min, the nebulized...

journal_title：Pharmaceutical development and technology

authors： Zhou Y,Brasel TL,Kracko D,Cheng YS,Ahuja A,Norenberg JP,Kelly HW

更新日期：2007-01-01 00:00:00

abstract：:The key for better antitumor efficacy is to improve the specificity of antitumor drugs for tumor cells and diminish their cytotoxicity to normal tissues. Targeted nanoparticles as antitumor drug delivery system can resolve this problem. In this study, we prepared folate and TAT (arginine-rich cell-penetrating peptide)...

journal_title：Pharmaceutical development and technology

authors： Zhang S,Liu Y,Gan Y,Qiu N,Gu Y,Zhu H

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:The purpose of the present investigation was to prepare a plasma stable, pH-sensitive niosomal formulation to enhance Sirolimus efficacy and selectivity. MATERIALS AND METHODS:pH-sensitive niosomal formulations bearing PEG-Poly (monomethyl itaconate)-CholC6 (PEG-PMMI-CholC6) copolymers and cholesteryl hemisu...

journal_title：Pharmaceutical development and technology

authors： Ghanbarzadeh S,Khorrami A,Pourmoazzen Z,Arami S

更新日期：2015-05-01 00:00:00

abstract：:The objective of the present work is to investigate the presence or absence of a critical concentration of maize starch according to the percolation theory for a truly ternary system with respect to a minimum disintegration time. The results of this study show that the application of percolation theory is not limited ...

journal_title：Pharmaceutical development and technology

authors： Kimura G,Puchkov M,Betz G,Leuenberger H

更新日期：2007-01-01 00:00:00

abstract：:The present study details the development of a small-scale spray-drying approach for the routine screening of amorphous solid dispersions (ASDs). This strategy aims to overcome the limitations of standard screening methodologies like solvent casting and quench cooling to predict drug-polymer miscibility of spray-dried...

journal_title：Pharmaceutical development and technology

authors： Ousset A,Bassand C,Chavez PF,Meeus J,Robin F,Schubert MA,Somville P,Dodou K

更新日期：2019-06-01 00:00:00

abstract：:The main objective of the present study was to improve bioavailability of diltiazem hydrochloride and decrease the frequency of dosage form administration by increasing the encapsulation efficiency of the drug, residence time of the dosage form at the site of absorption and sustained release of the drug from the deliv...

journal_title：Pharmaceutical development and technology

authors： Sultana Y,Mall S,Maurya DP,Kumar D,Das M

更新日期：2009-01-01 00:00:00

abstract：:Understanding variability in excipient physico-chemical properties is becoming an important aspect of Quality-by-Design drug product development. However, present experimental methods have only been able to study a few physico-chemical properties for a few excipient lots due to time, cost, and sample gathering conside...

journal_title：Pharmaceutical development and technology

authors： Kushner J 4th

更新日期：2013-03-01 00:00:00

abstract：:To improve the solubility and bioavailability of oridonin (ORI), glycerol monooleate lipid (GMO)- or phytantriol (PYT)-Poloxamer 407-propylene glycol-water systems were firstly used to develop cubosomes containing ORI for oral delivery. These cubosomes prepared through the fragmentation of bulk gels under homogenizati...

journal_title：Pharmaceutical development and technology

authors： Shi X,Peng T,Huang Y,Mei L,Gu Y,Huang J,Han K,Li G,Hu C,Pan X,Wu C

更新日期：2017-05-01 00:00:00

abstract：:In this study, chlorhexidine-loaded poly(ε-caprolactone) nanospheres (CHX-NS) were prepared and successfully coated on the urinary catheters. Properties of CHX-NS were evaluated including drug loading content and the nanosphere size. Effects of different lyoprotectants for long-term storage of CHX-NS were also investi...

journal_title：Pharmaceutical development and technology

authors： Srisang S,Nasongkla N

更新日期：2019-04-01 00:00:00

abstract：:The main purpose of this work was to study the albendazole-cyclodextrins complexation equilibrium and to propose a suitable excipient to improve the solubility behavior and dissolution rate of albendazole. The complexation of albendazole with four cyclodextrins, alpha-CD, beta-CD, gamma-CD, and hydroxypropylated (HP)-...

journal_title：Pharmaceutical development and technology

authors： Díaz D,Bernad Bernad MJ,Gracia Mora J,Escobar Llanos CM

更新日期：1998-08-01 00:00:00

abstract：:The present study was aimed to optimize capsulated unfolding type gastroretentive bilayer film constituting immediate release (IR) layer of amlodipine besylate and sustained release (SR) layer of atorvastatin calcium. A three-factor, three-level Box-Behnken-design was used to optimize bilayer film with dual-release ch...

journal_title：Pharmaceutical development and technology

authors： Porwal A,Dwivedi H,Pathak K

更新日期：2020-04-01 00:00:00

abstract：:The physical stability of amorphous solid dispersions (SDs) is influenced by their storage conditions. The goal of this work was to investigate the factors affecting the recrystallization of drugs in SDs after storage under conditions of high temperature and high humidity. SDs of three drugs (dipyridamole, nifedipine ...

journal_title：Pharmaceutical development and technology

authors： Shibata Y,Fujii M,Suzuki A,Koizumi N,Kanada K,Yamada M,Watanabe Y

更新日期：2014-06-01 00:00:00

abstract：:Drug-excipient compatibility studies lay the foundation for designing a chemically stable formulation for clinical and commercial development. This article describes the investigation of oxidative degradation encountered with compound A (a phenylalanine-drug complex) in a capsule dosage form. Two wet- granulation caps...

journal_title：Pharmaceutical development and technology

authors： Wu Y,Dali M,Gupta A,Raghavan K

更新日期：2009-01-01 00:00:00

abstract：:The aim of this study was to prepare various types of solid dispersions (SDs) by the hot-melt extrusion technique. Next, process analytical technology (PAT) such as Fourier transform-infrared (FT-IR) and Raman and near infrared (NIR) spectroscopy were applied to determine the solubilization effect. The SDs and its tab...

journal_title：Pharmaceutical development and technology

authors： Hwang I,Renuka V,Lee JH,Weon KY,Kang CY,Lee BJ,Park JB

更新日期：2020-06-01 00:00:00

abstract：:The utility of microcalorimetry as a rapid screening tool for assessing the solution stability of high molecular weight pharmaceutical proteins was evaluated by using model recombinant antibodies, Protein I and Protein II. Changes in the transition midpoint, T(m), were monitored as a function of pH and/or in the prese...

journal_title：Pharmaceutical development and technology

authors： Burton L,Gandhi R,Duke G,Paborji M

更新日期：2007-01-01 00:00:00

abstract：:This article describes a method to quantitatively track the solvation of HPC in a non-aqueous solvent system during topical gel manufacture. Where visual observation and microscopy could not establish a trend, straight-forward rheological profiling demonstrated a correlation between increased solvation of hydroxypropy...

journal_title：Pharmaceutical development and technology

authors： Potuck A,Leming R,Lam S

更新日期：2019-04-01 00:00:00

abstract：:Submicron colloidal suspensions of poly(epsilon-caprolactone) (PCL) were prepared by the solvent displacement method, using either the conventional form or a new recirculation device. In the latter case, a process that allows the recirculation of the aqueous phase into a device, providing a continuous flow, is propose...

journal_title：Pharmaceutical development and technology

authors： Piñón-Segundo E,Ganem-Quintanar A,Rafael Garibay-Bermúdez J,Juan Escobar-Chávez J,López-Cervantes M,Quintanar-Guerrero D

更新日期：2006-01-01 00:00:00

abstract：:Nucleic acids therapeutic efficiency is generally limited by their low stability and intracellular bioavailability, and by the toxicity of the carriers used to deliver them to the target sites. Aminated poly(glycerol methacrylate) polymers are biodegradable and pH-sensitive polymers that have been used previously to d...

journal_title：Pharmaceutical development and technology

authors： Morsi NG,Ali SM,Elsonbaty SS,Afifi AA,Hamad MA,Gao H,Elsabahy M

更新日期：2018-04-01 00:00:00

abstract：:Due to their light consistency and good spreadability, aqueous foams are considered as convenient and highly accepted drug carrier systems that are of great importance in the field of topical drug delivery. The production of a stable, easy to dose, preferably environmentally harmless foam formulation is challenging. T...

journal_title：Pharmaceutical development and technology

authors： Farkas D,Kállai-Szabó N,Sárádi-Kesztyűs Á,Lengyel M,Magramane S,Kiss É,Antal I

更新日期：2020-12-27 00:00:00

abstract：:Films of gellan gum:pectin blends were prepared by solvent casting method. Gellan gum:pectin mass ratios were varied (4:1; 1:1; 1:4) at different concentrations (3% or 4%) and glycerol was used as plasticizer (1 or 2%). The films were thin (18-30 µm), translucent, flexible, and homogeneous. The surface pH was suitable...

journal_title：Pharmaceutical development and technology

authors： Prezotti FG,Siedle I,Boni FI,Chorilli M,Müller I,Cury BSF

更新日期：2020-02-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cause of cancer-related death in both men and women. Often, surgical intervention remains the choice in treating CRC. Traditional dosage forms used for treating CRC deliver drug to wanted as well as unwanted sites of drug action resulting in several adverse side effects...

journal_title：Pharmaceutical development and technology

authors： Krishnaiah YS,Khan MA

更新日期：2012-09-01 00:00:00

abstract：:The compendial method of evaluation of orodispersible tablets (ODT) is the same disintegration test as for conventional tablets. Since it does not reflect the disintegration process in the oral cavity, alternative methods are proposed that are more related to in vivo conditions, e.g. modified dissolution paddle appara...

journal_title：Pharmaceutical development and technology

authors： Brniak W,Jachowicz R,Krupa A,Skorka T,Niwinski K

更新日期：2013-03-01 00:00:00

abstract：:Drug solubility testing in biorelevant media has become an indispensable tool in pharmaceutical development. Despite this importance, there is still an incomplete understanding of how poorly soluble compounds interact with these media. The aim of this study was to apply the concept of the apparent solubilization capac...

journal_title：Pharmaceutical development and technology

authors： Schwebel HJ,van Hoogevest P,Leigh ML,Kuentz M

更新日期：2011-06-01 00:00:00