Abstract:
:In this study, chlorhexidine-loaded poly(ε-caprolactone) nanospheres (CHX-NS) were prepared and successfully coated on the urinary catheters. Properties of CHX-NS were evaluated including drug loading content and the nanosphere size. Effects of different lyoprotectants for long-term storage of CHX-NS were also investigated. In vitro release study and antibacterial activity were also conducted using 20 cycles coated-urinary catheters. Results showed that the high-pressure emulsification-solvent evaporation technique provided the drug loading content at 1.14 ± 0.16% and the size of nanospheres was 152 ± 37 nm. The suitable lyoprotectant for long-term storage of CHX-NS was sucrose which provided noticeably no aggregation at the degree of reconstitution at 89.95%. The amount of CHX loading on coated catheters was at 4.55 ± 0.31 mg. Drug release from the coated catheters in artificial urine could be prolonged up to 2 weeks and bacteria proliferation was inhibited up to 14 days. These results suggest that the antimicrobial activity of CHX-NS reduces the adherence of the uropathogens to the catheter surface. Chlorhexidine-loaded polymeric nanospheres were fabricated which can be successfully coated on urinary catheters. These systems have potential use for prolonged antimicrobial applications.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Srisang S,Nasongkla Ndoi
10.1080/10837450.2018.1502317subject
Has Abstractpub_date
2019-04-01 00:00:00pages
402-409issue
4eissn
1083-7450issn
1097-9867journal_volume
24pub_type
杂志文章abstract::A high-pressure homogenization method for the production of aqueous suspensions of poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) was investigated. Depending on the production conditions it was possible to produce micro--as well as nanoparticulate systems without the use of organic solvents. The influence of dif...
journal_title:Pharmaceutical development and technology
pub_type: 杂志文章
doi:10.3109/10837459809009857
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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doi:10.3109/10837450.2011.649851
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journal_title:Pharmaceutical development and technology
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doi:10.3109/10837450.2010.513989
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
pub_type: 杂志文章
doi:10.1081/pdt-100101370
更新日期:1999-08-01 00:00:00
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journal_title:Pharmaceutical development and technology
pub_type: 杂志文章
doi:10.3109/10837450.2012.705294
更新日期:2013-02-01 00:00:00
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journal_title:Pharmaceutical development and technology
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更新日期:2010-09-01 00:00:00
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journal_title:Pharmaceutical development and technology
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更新日期:2020-12-27 00:00:00
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
pub_type: 杂志文章
doi:10.3109/10837459609031431
更新日期:1996-12-01 00:00:00
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journal_title:Pharmaceutical development and technology
pub_type: 杂志文章
doi:10.3109/10837450.2010.546413
更新日期:2012-07-01 00:00:00
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journal_title:Pharmaceutical development and technology
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doi:10.3109/10837450902882336
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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pub_type: 杂志文章,评审
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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更新日期:2003-08-01 00:00:00
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更新日期:2020-06-01 00:00:00
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
pub_type: 杂志文章
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journal_title:Pharmaceutical development and technology
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