Dynamic rheology as a quantitative method for real-time tracking of excipient solvation in non-aqueous hydroxypropylcellulose topical gels.

abstract：:Nucleic acids therapeutic efficiency is generally limited by their low stability and intracellular bioavailability, and by the toxicity of the carriers used to deliver them to the target sites. Aminated poly(glycerol methacrylate) polymers are biodegradable and pH-sensitive polymers that have been used previously to d...

journal_title：Pharmaceutical development and technology

authors： Morsi NG,Ali SM,Elsonbaty SS,Afifi AA,Hamad MA,Gao H,Elsabahy M

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:The purpose of the present investigation was to prepare a plasma stable, pH-sensitive niosomal formulation to enhance Sirolimus efficacy and selectivity. MATERIALS AND METHODS:pH-sensitive niosomal formulations bearing PEG-Poly (monomethyl itaconate)-CholC6 (PEG-PMMI-CholC6) copolymers and cholesteryl hemisu...

journal_title：Pharmaceutical development and technology

authors： Ghanbarzadeh S,Khorrami A,Pourmoazzen Z,Arami S

更新日期：2015-05-01 00:00:00

abstract：:The unstirred aqueous boundary layer (ABL) thickness was determined for modified Franz diffusion cells using three test compounds--parathion, 4-hexylresorcinol, and 2,4-dinitrochlorobenzene (DNCB). Steady-state fluxes through one, two, and three dialysis membranes in series were achieved in donor-saturated, infinite-d...

journal_title：Pharmaceutical development and technology

authors： Miller MA,Kasting G

更新日期：2012-11-01 00:00:00

abstract：:Microgels were prepared by cinnamic acid-gelatin (type B) conjugate (CA-GelB) and cinnamic acid-Pluronic F127 conjugate (CA-Plur). (1)H NMR confirmed that CA was conjugated to gelatin and the gelatin to CA residue molar ratio was estimated to be 1:4.7 by a colorimetric method. CA-Plur of which the CA residue to Plur m...

journal_title：Pharmaceutical development and technology

authors： Zhang H,Kim JC

更新日期：2016-01-01 00:00:00

abstract：:The purpose of this study was to assess the usefulness of waxy corn (maize) starch as a cofiller and diluent in pellets produced by aqueous extrusion-spheronization. Waxy corn starch was combined with microcrystalline cellulose (MCC) in the range of 20-50% of the entire composition. Pellets containing ordinary corn st...

journal_title：Pharmaceutical development and technology

authors： Junnila R,Palviainen P,Heinämäki J,Myllärinen P,Forssell P,Yliruusi J

更新日期：2000-01-01 00:00:00

abstract：:Quality by design (QbD) is an essential part of the modern approach to pharmaceutical quality. This study was conducted in the framework of a QbD project involving ramipril tablets. Preliminary work included identification of the critical quality attributes (CQAs) and critical process parameters (CPPs) based on the qu...

journal_title：Pharmaceutical development and technology

authors： Aksu B,Paradkar A,de Matas M,Özer Ö,Güneri T,York P

更新日期：2013-02-01 00:00:00

abstract：:Orally dissolving tablets (ODTs) represent one of the recent advances in drug delivery. The foremost objective of this study was to optimize the utilization of lubricant sodium stearyl fumarate in the preparation of dextromethorphan hydrobromide ODTs with enhanced taste-masking properties. The simple blending of sodiu...

journal_title：Pharmaceutical development and technology

authors： Mahrous GM,Ibrahim MA,Mostafa HF,Elzayat EM

更新日期：2019-07-01 00:00:00

abstract：:Drug solubility testing in biorelevant media has become an indispensable tool in pharmaceutical development. Despite this importance, there is still an incomplete understanding of how poorly soluble compounds interact with these media. The aim of this study was to apply the concept of the apparent solubilization capac...

journal_title：Pharmaceutical development and technology

authors： Schwebel HJ,van Hoogevest P,Leigh ML,Kuentz M

更新日期：2011-06-01 00:00:00

abstract：:The objective of this study was to compare the dissolution behavior of tablets prepared from solid dispersions with and without drug-carrier interactions. Diazepam and nifedipine were used as model drugs. Two types of carriers were used; polyvinylpyrrolidone (PVP K12, K30 and K60) and saccharides (inulin 1.8 kDa, 4 kD...

journal_title：Pharmaceutical development and technology

authors： Srinarong P,Kouwen S,Visser MR,Hinrichs WL,Frijlink HW

更新日期：2010-09-01 00:00:00

abstract：:To improve the solubility and bioavailability of oridonin (ORI), glycerol monooleate lipid (GMO)- or phytantriol (PYT)-Poloxamer 407-propylene glycol-water systems were firstly used to develop cubosomes containing ORI for oral delivery. These cubosomes prepared through the fragmentation of bulk gels under homogenizati...

journal_title：Pharmaceutical development and technology

authors： Shi X,Peng T,Huang Y,Mei L,Gu Y,Huang J,Han K,Li G,Hu C,Pan X,Wu C

更新日期：2017-05-01 00:00:00

abstract：:Substituting spacer by another in noninvasive ventilation (NIV) involves many variables, e.g. total emitted dose (TED), mass median aerodynamic diameter (MMAD), type of spacer, total lung deposition and total systemic absorption, which must be adjusted to ensure patient optimum therapy. Data mining based on artificial...

journal_title：Pharmaceutical development and technology

authors： Hussein RRS,M A Ali A,Salem HF,Abdelrahman MM,Said ASA,Abdelrahim MEA

更新日期：2017-11-01 00:00:00

abstract：:A colchicine release system utilizing biodegradable poly(phosphazenes) was investigated in vitro for intra-articular administration. Polymer degradation and drug release studies were performed on colchicine-loaded poly(phosphazenes) containing either imidazolyl (I-PPHOS) or ethyl glycinato (EG-PPHOS) side chain substi...

journal_title：Pharmaceutical development and technology

authors： Ibim SM,el-Amin SF,Goad ME,Ambrosio AM,Allcock HR,Laurencin CT

更新日期：1998-02-01 00:00:00

abstract：:The aim of the present study is to prepare risperidone-loaded poly lactic-co-glycolic acid (PLGA) microspheres within microfluidic system and to achieve a formulation with uniform size and monotonic and reproducible release profile. In comparison to batch method, T-junction and serpentine chips were utilized and optim...

journal_title：Pharmaceutical development and technology

authors： Jafarifar E,Hajialyani M,Akbari M,Rahimi M,Shokoohinia Y,Fattahi A

更新日期：2017-09-01 00:00:00

abstract：:The purpose of this research was to design and develop a novel controlled-release bead formulation for oral administration with buffer crystals as a carrier for loading of fenoldopam mesylate, an intravenous antihypertensive agent, which provides an in vitro release rate of 30-50 mg/hr for 6-8 hr. Buffer crystals were...

journal_title：Pharmaceutical development and technology

authors： Venkatesh GM

更新日期：1998-11-01 00:00:00

abstract：:Transdermal drug administration has a number of advantages that cannot be leveraged for therapeutic benefits because of the robust barrier provided by the stratum corneum. One of the promising techniques for circumventing the stratum corneum is sonophoresis - the use of ultrasound for facilitating transdermal drug del...

journal_title：Pharmaceutical development and technology

authors： Ita K

更新日期：2017-06-01 00:00:00

abstract：:Effects of various factors, such as light intensity, polarizability of n-alcohol solvents, addition of colorants, and viscosity of solutions on the kinetics of the photoisomerization of therapeutically effective E-isomer of sorivudine to its less effective Z-isomer were studied. Solutions of known concentrations of E-...

journal_title：Pharmaceutical development and technology

authors： Desai D,Li D,Janjikhel R,Lang B,Jain N

更新日期：2001-01-01 00:00:00

abstract：:The objective of this study was to investigate the effect of the physiological parameters (pH, buffer capacity, and ionic strength) of the gastrointestinal (GI) fluid on the dissolution behavior of the class II weakly acidic (BCS class IIa) drug valsartan. A series of in vitro dissolution studies was carried out on Di...

journal_title：Pharmaceutical development and technology

authors： Hamed R

更新日期：2018-12-01 00:00:00

abstract：:The objective of this paper was to evaluate the mucoadhesive and sustained-release properties of the water-soluble gum obtained from Hakea gibbosa (hakea), for the formulation of buccal tablets. Flatfaced tablets containing hakea were formulated using chlorpheniramine maleate (CPM) as a model drug. Two types of tablet...

journal_title：Pharmaceutical development and technology

authors： Alur HH,Pather SI,Mitra AK,Johnston TP

更新日期：1999-08-01 00:00:00

abstract：:Magnesium stearate (MgSt) is a widely used pharmaceutical lubricant in tablet manufacturing. However, batch-to-batch variability in hydrate form and surface area can lead to inconsistency in tablet performance. In this work, several unique MgSt samples were studied: traditional monohydrate samples with high surface ar...

journal_title：Pharmaceutical development and technology

authors： Calahan JL,Paul S,Yanez EG,DeNeve D,Sun CC,Munson EJ

更新日期：2021-02-01 00:00:00

abstract：:The physicochemical properties and enzymatic stability of esters of phenylephrone, synthesized on the basis of the chemical delivery system (CDS) concept, were studied as a new class of mydriatic agents. Potentiometrically determined ionization constants (pKa) of the novel compounds were in the range 7.19-7.21. The th...

journal_title：Pharmaceutical development and technology

authors： Goskonda VR,Khan MA,Bodor NS,Reddy IK

更新日期：1999-05-01 00:00:00

abstract：:Pulmonary delivery of peptides remains an important, noninvasive route of administration that is attractive because it offers high bioavailability and patient compliance. Optimization of particle characteristics for deposition in the deep regions of the lung after inhalation and retention of peptide stability are key ...

journal_title：Pharmaceutical development and technology

authors： Poursina N,Vatanara A,Rouini MR,Gilani K,Rouholamini Najafabadi A

更新日期：2017-09-01 00:00:00

abstract：:The main objective of this study was to design positively charged Levofloxacin Hemihydrate (Levo-h)-loaded nanoparticles with improved entrapment efficiency and antibacterial activity. PLGA alone or in combinations with Eudragit® RLPO or RS30D with or without positively charged inducing agent; 1,2-dioleoyl-3-trimethyl...

journal_title：Pharmaceutical development and technology

authors： Hasan AA,Sabry SA,Abdallah MH,El-Damasy DA

更新日期：2016-09-01 00:00:00

abstract：:The oral administration route is considered to be the most widely used route because of its convenience of administration and manufacturing. Dosage forms, like orally disintegrating tablets (ODTs), mini tablets, and orally disintegrating mini tablets (ODMTs), are recognized as promising for use in pediatric patients. ...

journal_title：Pharmaceutical development and technology

authors： Comoglu T,Dilek Ozyilmaz E

更新日期：2019-09-01 00:00:00

abstract：:Tablet hardness, a measure of the breaking force of a tablet, is based on numerous factors. These include the shape of the tablet and the mode of the application of force. For instance, when a pentagonal-shaped tablet was tested with a traditional hardness tester with flat platens, there was a large variation in hardn...

journal_title：Pharmaceutical development and technology

authors： Malladi J,Sidik K,Wu S,McCann R,Dougherty J,Parab P,Carragher T

更新日期：2017-03-01 00:00:00

abstract：:Oily liquid drugs are not convenient for oral administration. We developed a powder containing clofibrate (CF), a model of an oily drug, using aminoalkyl methacrylate copolymer (EPO) or methacrylic acid copolymer (L100). CF or a mixture of CF and soybean oil was emulsified with EPO or L100 aqueous solution. Using a hi...

journal_title：Pharmaceutical development and technology

authors： Fujii M,Kawakami A,Saito A,Tuchiya H,Koizumi N,Watanabe Y

更新日期：2016-12-01 00:00:00

abstract：:The main objective of this research is to use the near-infrared diffuse reflectance method to evaluate and quantify the effects of hardness and porosity on the near-infrared spectras of tablets. To develop a model equation, validate the model and test the model predictive ability. Seven theophylline tablet formulation...

journal_title：Pharmaceutical development and technology

authors： Donoso M,Kildsig DO,Ghaly ES

更新日期：2003-01-01 00:00:00

abstract：:The object of this study was to enhance the solubility, dissolution rate, and oral bioavailability of rutin by complexation with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD). The interaction of rutin with cyclodextrins (CyDs) was evaluated by the solubility, and ultraviolet (UV) and circular dichroism (CD) spectrop...

journal_title：Pharmaceutical development and technology

authors： Miyake K,Arima H,Hirayama F,Yamamoto M,Horikawa T,Sumiyoshi H,Noda S,Uekama K

更新日期：2000-01-01 00:00:00

abstract：:Supercritical fluid extraction (SFE), with carbon dioxide as the solvent, was tested for its ability to remove common reactive impurities from several pharmaceutical excipient powders including starch, microcrystalline cellulose (MCC), hydroxypropylcellulose (HPC), polyethylene oxide (PEO), and polyvinylpyrrolidone (P...

journal_title：Pharmaceutical development and technology

authors： Ashraf-Khorassani M,Taylor LT,Waterman KC,Narayan P,Brannegan DR,Reid GL

更新日期：2005-01-01 00:00:00

abstract：:An anomalous peak was observed in the HPLC/UV analysis of a developmental drug product. High resolution LC/MS revealed that the mass of this degradant was 12 Da greater than the drug substance, corresponding to a net gain of a single carbon atom. The degradant was reproduced by incubating the drug substance with forma...

journal_title：Pharmaceutical development and technology

authors： Zhong Q,Stowers S,Segraves NL,Ngim KK,Zhang K,Bostick T,Deese A,Chetwyn NP

更新日期：2013-07-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cause of cancer-related death in both men and women. Often, surgical intervention remains the choice in treating CRC. Traditional dosage forms used for treating CRC deliver drug to wanted as well as unwanted sites of drug action resulting in several adverse side effects...

journal_title：Pharmaceutical development and technology

authors： Krishnaiah YS,Khan MA

更新日期：2012-09-01 00:00:00