Doxorubicin-loaded microgels composed of cinnamic acid-gelatin conjugate and cinnamic acid-Pluronic F127 conjugate.

abstract：:The purpose of this study was to investigate the effect of the composition of a binary powder mixture on the bonding index, the brittle fracture index, and the strain index, as defined by Hiestand. The studies involved tensile strength and dynamic indentation hardness determinations of square compacts, the solid fract...

journal_title：Pharmaceutical development and technology

authors： Majuru S,Wurster DE

更新日期：1997-11-01 00:00:00

abstract：:The interaction of 5-nitro-2-furfurilylidene benzhydrazide (5NFB), potential anti-trypanosomal compound, with micellar solutions was studied. The results indicated that 50 mug of 5NFB completely kills 20 million T. cruzi epimastigote cells within 3 days, whereas the same amount of benznidazole kills 30% of the cells a...

journal_title：Pharmaceutical development and technology

authors： Rangel-Yagui CO,Hsu HW,Barbosa LR,Caetano W,Pessoa A Jr,Tavares LC,Itri R

更新日期：2007-01-01 00:00:00

abstract：:Starches obtained from four different Dioscorea species namely White (D. rotundata), Bitter (D. dumetorum), Chinese (D. oppositifolia) and Water yam (D. alata), were modified by acid hydrolysis and the physicochemical, material and tablet formation properties of the starches were investigated with the aim of determini...

journal_title：Pharmaceutical development and technology

authors： Odeku OA,Picker-Freyer KM

更新日期：2009-01-01 00:00:00

abstract：:The dry coating process was evaluated in terms of storage stability investigating drug release and agglomeration tendency of the different coated oral dosage forms; hydroxypropyl methylcellulose acetate succinate (HPMCAS) was used with triethylcitrate (TEC) as plasticizer and acetylated monoglyceride (Myvacet) as wett...

journal_title：Pharmaceutical development and technology

authors： Kablitz CD,Urbanetz NA

更新日期：2009-01-01 00:00:00

abstract：:The biopharmaceutical assessment of new drug candidates based on their chemical structure is important in drug discovery and development. The scope of this study is to focus on lipophilic drugs and to clarify the role of their chemical predictors on oral bioavailability in humans. First their chemical properties were ...

journal_title：Pharmaceutical development and technology

authors： Kuentz MT,Arnold Y

更新日期：2009-01-01 00:00:00

abstract：:The objectives of this research were to evaluate the stability of lercanidipine in solution state and solid state and explore the compatibility of drug with oils, surfactants and cosurfactants as excipients. The effect of pH on the degradation in solution state was studied through pH-rate profile of lercanidipine in c...

journal_title：Pharmaceutical development and technology

authors： Parmar N,Amin S,Singla N,Kohli K

更新日期：2012-11-01 00:00:00

abstract：CONTEXT:Freeze-drying in presence of excipients is a common practice to stabilize biomacromolecular formulations. The composition of this formulation is known to affect the quality of the final product. OBJECTIVE:The aim of this study was to evaluate freeze-drying in well-plates as a high throughput platform for formu...

journal_title：Pharmaceutical development and technology

authors： Trnka H,Rantanen J,Grohganz H

更新日期：2015-01-01 00:00:00

abstract：:The investigation was aimed at developing thermodynamically stable topical delivery system of nanostructured lipid carrier of econazole nitrate (EN) for the treatment of deep seated fungal infection by improving its permeability. Fifteen formulations (F1-F15) of nanostructured lipid carriers (NLCs) were prepared by so...

journal_title：Pharmaceutical development and technology

authors： Keshri L,Pathak K

更新日期：2013-05-01 00:00:00

abstract：:The objective of the present work is to investigate the presence or absence of a critical concentration of maize starch according to the percolation theory for a truly ternary system with respect to a minimum disintegration time. The results of this study show that the application of percolation theory is not limited ...

journal_title：Pharmaceutical development and technology

authors： Kimura G,Puchkov M,Betz G,Leuenberger H

更新日期：2007-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of solid carriers and processing routes on the properties of amorphous solid dispersions of itraconazole. Three solid carriers with a range of surface properties were studied, (1) a mesoporous silicate, magnesium aluminum silicate (Neusilin US2), (2) a nonporous sil...

journal_title：Pharmaceutical development and technology

authors： Grobelny P,Kazakevich I,Zhang D,Bogner R

更新日期：2015-01-01 00:00:00

abstract：:Novel fast-disintegrating multi-unit tablets (FDMUTs) were prepared to modify the release of lornoxicam (a potent non-steroidal anti-inflammatory drug with a short half-life) as well as to combine the advantages of multi-unit systems with the cost-effectiveness of compressed tablets. The proposed FDMUTs consisted of s...

journal_title：Pharmaceutical development and technology

authors： Aburahma MH,Hamza Yel-S

更新日期：2011-08-01 00:00:00

abstract：:The purpose of this study was a comparative evaluation of miniaturized vs. University of Minnesota's (i.e., U of Minn. = Hiestand's) procedures for determining the tensile strength, indentation hardness, and bonding index (BI), one out of three Indices of Tableting Performance (ITP). Tableting properties of six direct...

journal_title：Pharmaceutical development and technology

authors： Lamey K,Schwartz J,Muller F

更新日期：2003-08-01 00:00:00

abstract：:The present study was aimed to develop a matrix-type transdermal formulation of pentazocine using mixed polymeric grades of Eudragit RL/RS. The possible interaction between drug and polymer used were characterized by FTIR, DSC and X-RD. X-RD study indicates a change of state of drug from crystalline to amorphous in th...

journal_title：Pharmaceutical development and technology

authors： Chandak AR,Prasad Verma PR

更新日期：2010-06-01 00:00:00

abstract：:This work aimed to incorporate Dexibuprofen (DXI), the pharmacologically active and more potent form of ibuprofen, into polymeric micelles based tablets with enhanced oral bioavailability. Thin film hydration technique was employed to prepare DXI polymeric micelles using Pluronic® F127 and/or P123 solutions in differe...

journal_title：Pharmaceutical development and technology

authors： Abdelbary G,Makhlouf A

更新日期：2014-09-01 00:00:00

abstract：:In recent years, drug delivery systems such as liposomes and microparticles have been used in clinic for the treatment of different diseases and from a regulatory point of view, a parenterally applied drug and drug delivery systems must be sterile and pyrogen free. Radiation sterilization is a method recognized by pha...

journal_title：Pharmaceutical development and technology

authors： Sakar F,Özer AY,Erdogan S,Ekizoglu M,Kart D,Özalp M,Colak S,Zencir Y

更新日期：2017-09-01 00:00:00

abstract：:Mefenamic acid (MA), a poorly water-soluble drug, was used as a model substance to investigate granules and tablet characteristics to be optimized for the loading volume of MA (0-74.1% v/v) in the formulation including lactose monohydrate/maize starch (7/3) as excipients. The compactibility of granules increased with ...

journal_title：Pharmaceutical development and technology

authors： Kimura G,Betz G,Leuenberger H

更新日期：2008-01-01 00:00:00

abstract：:A carbopol 934P-based drug delivery system (AmDDS) was developed to achieve the dual-controlled delivery of Nonoxynol-9 (N-9), a spermicidal agent, and EDTA, a potentiator of spermicidal activity. This gel-type system made intimate contact with vaginal mucosa and maintained an effective drug concentration within the v...

journal_title：Pharmaceutical development and technology

authors： Lee CH,Chien YW

更新日期：1996-07-01 00:00:00

abstract：:Oily liquid drugs are not convenient for oral administration. We developed a powder containing clofibrate (CF), a model of an oily drug, using aminoalkyl methacrylate copolymer (EPO) or methacrylic acid copolymer (L100). CF or a mixture of CF and soybean oil was emulsified with EPO or L100 aqueous solution. Using a hi...

journal_title：Pharmaceutical development and technology

authors： Fujii M,Kawakami A,Saito A,Tuchiya H,Koizumi N,Watanabe Y

更新日期：2016-12-01 00:00:00

abstract：:There is as yet no commercialized preparation for oral administration of flecainide acetate (FA) to children. In such cases, manipulation of commercial tablets is the usual practice in pharmacy services of hospitals and compounding pharmacies, to provide a suitable dosage form for this vulnerable pediatric population ...

journal_title：Pharmaceutical development and technology

authors： Santoveña A,Charola I,Suárez-González J,Teigell-Pérez N,García-van Nood S,Soriano M,Fariña JB

更新日期：2018-12-01 00:00:00

abstract：:Substituting spacer by another in noninvasive ventilation (NIV) involves many variables, e.g. total emitted dose (TED), mass median aerodynamic diameter (MMAD), type of spacer, total lung deposition and total systemic absorption, which must be adjusted to ensure patient optimum therapy. Data mining based on artificial...

journal_title：Pharmaceutical development and technology

authors： Hussein RRS,M A Ali A,Salem HF,Abdelrahman MM,Said ASA,Abdelrahim MEA

更新日期：2017-11-01 00:00:00

abstract：:In the current study, the influence of chitosan on the dissolution rate and bioavailability of acyclovir has been illustrated through the preparation of co-crystals by simple solvent change method. Chitosan was precipitated on acyclovir crystals using sodium citrate as the salting out agent. The pure drug and the prep...

journal_title：Pharmaceutical development and technology

authors： Allam AN,Naggar VF,El Gamal SS

更新日期：2013-07-01 00:00:00

abstract：:Films of gellan gum:pectin blends were prepared by solvent casting method. Gellan gum:pectin mass ratios were varied (4:1; 1:1; 1:4) at different concentrations (3% or 4%) and glycerol was used as plasticizer (1 or 2%). The films were thin (18-30 µm), translucent, flexible, and homogeneous. The surface pH was suitable...

journal_title：Pharmaceutical development and technology

authors： Prezotti FG,Siedle I,Boni FI,Chorilli M,Müller I,Cury BSF

更新日期：2020-02-01 00:00:00

abstract：:Quality by design (QbD) is an essential part of the modern approach to pharmaceutical quality. This study was conducted in the framework of a QbD project involving ramipril tablets. Preliminary work included identification of the critical quality attributes (CQAs) and critical process parameters (CPPs) based on the qu...

journal_title：Pharmaceutical development and technology

authors： Aksu B,Paradkar A,de Matas M,Özer Ö,Güneri T,York P

更新日期：2013-02-01 00:00:00

abstract：:The present study reports the solid-state properties of Fluvastatin sodium salt crystallized from different solvents for comparison with crystalline forms of the commercially available raw material and United States Pharmacopeia (USP) reference standard. Fluvastatin (FLV) samples were characterized by several techniqu...

journal_title：Pharmaceutical development and technology

authors： Borgmann SH,Bernardi LS,Rauber GS,Oliveira PR,Campos CE,Monti G,Cuffini SL,Cardoso SG

更新日期：2013-03-01 00:00:00

abstract：:Vardenafil hydrochloride (VAR) is an erectile dysfunction treating drug. VAR has a short elimination half-life (4-5 h) and suffers low oral bioavailability (15%). This work aimed to explore the dual potential of VAR-dendrimer complexes as drug release modulators and oral bioavailability enhancers. VAR-dendrimer comple...

journal_title：Pharmaceutical development and technology

authors： Tawfik MA,Tadros MI,Mohamed MI

更新日期：2019-03-01 00:00:00

abstract：:Understanding variability in excipient physico-chemical properties is becoming an important aspect of Quality-by-Design drug product development. However, present experimental methods have only been able to study a few physico-chemical properties for a few excipient lots due to time, cost, and sample gathering conside...

journal_title：Pharmaceutical development and technology

authors： Kushner J 4th

更新日期：2013-03-01 00:00:00

abstract：:Novel buccal adhesive system (NBAS) containing Nimodipine (N) was prepared and evaluated by different parameters such as weight uniformity, thickness, hardness, surface pH, swelling index, mucoadhesive strength (MS), in vitro drug release and ex vivo drug permeation. Different formulations containing 5-20% Carbopol 93...

journal_title：Pharmaceutical development and technology

authors： Hassan N,Ali M,Ali J

更新日期：2010-03-01 00:00:00

abstract：:The present study details the development of a small-scale spray-drying approach for the routine screening of amorphous solid dispersions (ASDs). This strategy aims to overcome the limitations of standard screening methodologies like solvent casting and quench cooling to predict drug-polymer miscibility of spray-dried...

journal_title：Pharmaceutical development and technology

authors： Ousset A,Bassand C,Chavez PF,Meeus J,Robin F,Schubert MA,Somville P,Dodou K

更新日期：2019-06-01 00:00:00

abstract：:A novel analytical procedure has been developed for quantitative determination of levodopa and carbidopa in aqueous binary solutions acidified by HCl and without any other sample pretreatment. The method is based partially on least squares treatment of data obtained by attenuated total reflectance Fourier transform in...

journal_title：Pharmaceutical development and technology

authors： Khanmohammadi M,Mobedi E,Garmarudi AB,Mobedi H,Kargosha K

更新日期：2007-01-01 00:00:00

abstract：:The aim of the present investigation was to develop and study topical gel delivery of curcumin for its anti-inflammatory effects. Carbopol 934P (CRB) and hydroxypropylcellulose (HPC) were used for the preparation of gels. The penetration enhancing effect of menthol (0-12.5% w/w) on the percutaneous flux of curcumin th...

journal_title：Pharmaceutical development and technology

authors： Patel NA,Patel NJ,Patel RP

更新日期：2009-01-01 00:00:00