Abstract:
:Starches obtained from four different Dioscorea species namely White (D. rotundata), Bitter (D. dumetorum), Chinese (D. oppositifolia) and Water yam (D. alata), were modified by acid hydrolysis and the physicochemical, material and tablet formation properties of the starches were investigated with the aim of determining their usefulness as a direct compression excipient in pharmaceutical tablets. The results obtained indicate that the physicochemical, material and tablet properties of the acid modified Dioscorea starches varied considerably among the various species. Acid hydrolysis led to an increase in solubility but decrease in swelling of the starches. Acid modification also led to an increase in the compressibility of the starches when compared with the native forms of the starches. Acid modified Water and White formed intact stable tablets only at higher rho(rel,) (max), while acid modified Chinese and Bitter formed tablets at all relative densities which could already be predicted from the deformation behaviour as analyzed by 3-D modeling. The result indicates that acid modified starch tablets showed higher crushing force and acceptable disintegration time and could therefore be useful as directly compressible excipient.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Odeku OA,Picker-Freyer KMdoi
10.1080/10837450802572367subject
Has Abstractpub_date
2009-01-01 00:00:00pages
259-70issue
3eissn
1083-7450issn
1097-9867journal_volume
14pub_type
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