Abstract：
:Mefenamic acid (MA), a poorly water-soluble drug, was used as a model substance to investigate granules and tablet characteristics to be optimized for the loading volume of MA (0-74.1% v/v) in the formulation including lactose monohydrate/maize starch (7/3) as excipients. The compactibility of granules increased with loading volume of MA. This was related to the brittle behavior of MA during compression and the increase of intragranular pore volume of granules. The minimum disintegration time (266 +/- 8.3 s) was found in the tablet that was composed of 55.1% v/v MA and 13.6% v/v maize starch. The determination of the critical concentration of disintegrant (% v/v) required for a minimum disintegration time may be useful for solid dosage form design.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Kimura G,Betz G,Leuenberger Hdoi
10.1080/10837450701702941subject
Has Abstractpub_date
2008-01-01 00:00:00pages
57-64issue
1eissn
1083-7450issn
1097-9867pii
790905223journal_volume
13pub_type
杂志文章abstract：:Flecainide base is pharmaceutically active substance used for production of flecainide acetate which is known in market as Tambacor, Almarytm, Apocard, Ecrinal or Flecaine. It is determined that flecainide base forms four polymorphic forms abbreviated as Ib, IIb, IIIb and IVb. Flecainide base form Ib is thermodynamica...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2013.763259
更新日期：2014-02-01 00:00:00
abstract：:The instability of protein and antigen(s) during encapsulation in biodegradable polymers by water-in-oil-in-water (w/o/w) encapsulation is well established. The aim of present study is to screen various additives to prevent the inactivation and loss of immunogenicity of HBsAg upon its exposure to the water/CH(2)Cl(2) ...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2010.546408
更新日期：2012-07-01 00:00:00
abstract：:The objective of this paper was to evaluate the mucoadhesive and sustained-release properties of the water-soluble gum obtained from Hakea gibbosa (hakea), for the formulation of buccal tablets. Flatfaced tablets containing hakea were formulated using chlorpheniramine maleate (CPM) as a model drug. Two types of tablet...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1081/pdt-100101370
更新日期：1999-08-01 00:00:00
abstract：:The present study was aimed to optimize capsulated unfolding type gastroretentive bilayer film constituting immediate release (IR) layer of amlodipine besylate and sustained release (SR) layer of atorvastatin calcium. A three-factor, three-level Box-Behnken-design was used to optimize bilayer film with dual-release ch...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450.2019.1705486
更新日期：2020-04-01 00:00:00
abstract：:The object of this study was to enhance the solubility, dissolution rate, and oral bioavailability of rutin by complexation with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD). The interaction of rutin with cyclodextrins (CyDs) was evaluated by the solubility, and ultraviolet (UV) and circular dichroism (CD) spectrop...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1081/pdt-100100556
更新日期：2000-01-01 00:00:00
abstract：:The aim of this study was to investigate the effects of solid carriers and processing routes on the properties of amorphous solid dispersions of itraconazole. Three solid carriers with a range of surface properties were studied, (1) a mesoporous silicate, magnesium aluminum silicate (Neusilin US2), (2) a nonporous sil...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2014.959181
更新日期：2015-01-01 00:00:00
abstract：:Ternary complexes of meloxicam (ML), a poorly water-soluble anti-inflammatory drug, with β-cyclodextrin (βCD) and polyethylene glycol (PEG) 6000 were prepared from an equimolar (ML-βCD) and 10% of PEG. Characterization of the ternary complex was carried out by differential scanning calorimetry and X-ray diffractometry...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2011.565347
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:Aerodynamically stable, nebulized aerosols are desirable to achieve optimum asthma therapy. Stabilizing droplet size using gel-forming polymers may assist in achieving this goal. Semisolid particles may be generated through aerosolization of a polymer solution. Gelatin was employed as a model polymer in a proce...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1081/pdt-120003483
更新日期：2002-05-01 00:00:00
abstract：:The objective of the study was to mask the unpleasant taste of captopril (CPT). Taste masking was achieved by complexation of CPT with a basic ion exchange resin, Dowex® 66, using the batch method. Dowex® 66 was used for the adsorption of CPT, and physical and chemical parameters of the CPT resinates complex were eval...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450.2019.1687520
更新日期：2020-03-01 00:00:00
abstract：:The objective of this study was to develop a floating, pulsatile, multiparticulate drug delivery system intended for chronopharmacotherapy of arthritis. The floating pulsatile drug delivery has the advantage that a drug can be released in the upper gastrointestinal tract after a definite time period of no drug release...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450903095334
更新日期：2010-03-01 00:00:00
abstract：:The purpose of this study was to investigate the effect of the composition of a binary powder mixture on the bonding index, the brittle fracture index, and the strain index, as defined by Hiestand. The studies involved tensile strength and dynamic indentation hardness determinations of square compacts, the solid fract...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837459709022630
更新日期：1997-11-01 00:00:00
abstract：:Orally dissolving tablets (ODTs) represent one of the recent advances in drug delivery. The foremost objective of this study was to optimize the utilization of lubricant sodium stearyl fumarate in the preparation of dextromethorphan hydrobromide ODTs with enhanced taste-masking properties. The simple blending of sodiu...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450.2019.1579228
更新日期：2019-07-01 00:00:00
abstract：:Mechanically generated radicals were shown to affect short-term stability of a model pharmaceutical formulation during high-shear processing. A formulation containing an oxidatively sensitive drug, either amorphous or crystalline, and a polymeric excipient was high-shear mixed and the resulting short-term degradation ...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450802328869
更新日期：2008-01-01 00:00:00
abstract：:The purpose of this study was a comparative evaluation of miniaturized vs. University of Minnesota's (i.e., U of Minn. = Hiestand's) procedures for determining the tensile strength, indentation hardness, and bonding index (BI), one out of three Indices of Tableting Performance (ITP). Tableting properties of six direct...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1081/pdt-120022153
更新日期：2003-08-01 00:00:00
abstract：:A new approach to developing a drug-polymer mixed coat for highly water-soluble diltiazem pellets was investigated at different coating levels. Drug layering and the coating procedures were performed using a bottom spray fluidized bed coater. Drug pellets were coated with Eudragit NE40 (NE40) alone and in combination ...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450500464008
更新日期：2006-02-01 00:00:00
abstract：:The aim of the present study is to prepare risperidone-loaded poly lactic-co-glycolic acid (PLGA) microspheres within microfluidic system and to achieve a formulation with uniform size and monotonic and reproducible release profile. In comparison to batch method, T-junction and serpentine chips were utilized and optim...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450.2016.1221426
更新日期：2017-09-01 00:00:00
abstract：:The biopharmaceutical assessment of new drug candidates based on their chemical structure is important in drug discovery and development. The scope of this study is to focus on lipophilic drugs and to clarify the role of their chemical predictors on oral bioavailability in humans. First their chemical properties were ...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450802626296
更新日期：2009-01-01 00:00:00
abstract：:The main purpose of this work was to study the albendazole-cyclodextrins complexation equilibrium and to propose a suitable excipient to improve the solubility behavior and dissolution rate of albendazole. The complexation of albendazole with four cyclodextrins, alpha-CD, beta-CD, gamma-CD, and hydroxypropylated (HP)-...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837459809009867
更新日期：1998-08-01 00:00:00
abstract：:Background: Clindamycin's bitter taste and odor is known to affect treatment adherence in children. Recently, a formulation of clindamycin HCl complexed with ion exchange resin IRP 69 was shown to mask the bitter taste. Because of the potential benefit of this formulation for children, a pilot study using a porcine mo...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章,随机对照试验
doi：10.1080/10837450.2019.1624771
更新日期：2019-10-01 00:00:00
abstract：:The present work investigated the magnitude of microsphere-induced acute myotoxicity and determined whether this myotoxicity is related to microsphere size and/or reconstitution solvent. Using a high molecular weight poly(dl-lactide-co-glycolide) copolymer, the myotoxicity of two different size microsphere formulation...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837459609022596
更新日期：1996-10-01 00:00:00
abstract：:A novel analytical procedure has been developed for quantitative determination of levodopa and carbidopa in aqueous binary solutions acidified by HCl and without any other sample pretreatment. The method is based partially on least squares treatment of data obtained by attenuated total reflectance Fourier transform in...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450701481249
更新日期：2007-01-01 00:00:00
abstract：:The aim of this study was to prepare electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats and to incorporate plai oil (Zingiber Cassumunar Roxb.). The plai oil with 10, 20 and 30% wt to polymer were incorporated in the PVP/HPβCD solution and electrospun to obtain nanofibers. The...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2013.788659
更新日期：2014-06-01 00:00:00
abstract：:The present study was carried out in order to mask the bitter taste of the Etoricoxib by complexation with cation-exchange resin, Indion 204. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 mi...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450903322787
更新日期：2010-09-01 00:00:00
abstract：:The purpose of this study was to develop a benchtop apparatus to simulate the scale-up of the moist-heat sterilization process of sodium carboxymethylcellulose (CMC) gel and identify critical process parameters that affect the sterilized gel viscosity. A 600-ml benchtop Parr reactor was modified and used to achieve go...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1081/pdt-100101394
更新日期：1999-01-01 00:00:00
abstract：:Objective: A polymer-based nanoparticle was constructed to target sorafenib delivery to colorectal carcinoma cells and decrease the side effects of the drug.Methods: Sorafenib-loaded nanoparticles (S-NPs) based on PEG-PLGA were prepared using a double emulsion solvent evaporation method. The properties of S-NPs were e...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450.2020.1718704
更新日期：2020-06-01 00:00:00
abstract：CONTEXT:Skin delivery of Meloxicam (MX) offers several advantages over the oral route which is associated with potential side effects. OBJECTIVES:The aim of this study was to develop transdermal MX in niosomes. MATERIALS AND METHODS:Vesicles prepared by thin film hydration method were characterized and the acute anti...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450.2011.598166
更新日期：2013-07-01 00:00:00
abstract：:The dry coating process was evaluated in terms of storage stability investigating drug release and agglomeration tendency of the different coated oral dosage forms; hydroxypropyl methylcellulose acetate succinate (HPMCAS) was used with triethylcitrate (TEC) as plasticizer and acetylated monoglyceride (Myvacet) as wett...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.3109/10837450902882336
更新日期：2009-01-01 00:00:00
abstract：:The purpose of this work was to investigate the effect that changes in design and process variables had on the movement of particles around a fluidized bed coating apparatus. To measure the mean and variance of the particle cycle time distribution (CTD), the number of passages taken by a magnetic tracer particle throu...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1081/pdt-100100546
更新日期：2000-01-01 00:00:00
abstract：:Clinical trials of cholesterol ester transfer protein (CETP) peptide vaccine were stopped after disappointing results in humans due to the inadequacy of adjuvant aluminum hydroxide in stimulating the immune response against the self-antigen of CETP. To increase the efficacy of the CETP vaccine, we developed a novel li...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450.2019.1706181
更新日期：2020-04-01 00:00:00
abstract：:The objective of the present study was to coprocess 2 active pharmaceutical ingredients (APIs), nevirapine (NVP) and stavudine (STV), by spray drying technique to overcome the respective problems of poor solubility and poor content uniformity. The coprocessed product (NVP-STV CP) and untreated APIs were characterized ...
journal_title：Pharmaceutical development and technology
pub_type： 杂志文章
doi：10.1080/10837450802089164
更新日期：2008-01-01 00:00:00
