Abstract:
CONTEXT:Skin delivery of Meloxicam (MX) offers several advantages over the oral route which is associated with potential side effects. OBJECTIVES:The aim of this study was to develop transdermal MX in niosomes. MATERIALS AND METHODS:Vesicles prepared by thin film hydration method were characterized and the acute anti-inflammatory activity of 0.5% MX niosomal hydrogel was evaluated using carrageenan induced rat paw edema method. RESULTS:The results revealed that niosomes prepared from span 60 and cholesterol at 6:4 molar ratio using 20 mg of MX were of the highest entrapment efficiency (> 55%) and with particle size (187.3 nm). There was a marked increase in the percentage inhibition of edema in animals treated with MX vesicular gel compared to those treated with free MX and piroxicam gels. DISCUSSION:There was an inverse proportionality between vesicle size and cholesterol content. With increased cholesterol molar ratio the bilayer stability increased and permeability decreased leading to efficiently trapping the MX. In contrast, higher amounts of cholesterol may compete with the drug for packing space within the bilayer. The inhibitory effect of MX niosomal gel may be attributed to its superior skin permeation. CONCLUSIONS:The results suggest that niosomes may be promising vehicles for transdermal delivery of MX.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
El-Menshawe SF,Hussein AKdoi
10.3109/10837450.2011.598166subject
Has Abstractpub_date
2013-07-01 00:00:00pages
779-86issue
4eissn
1083-7450issn
1097-9867journal_volume
18pub_type
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