Abstract:
:The general solubility equation (GSE) is the state-of-the-art method for estimating the aqueous solubilities of organic compounds. It is an extremely simple equation that expresses aqueous solubility as a function of only two inputs: the octanol-water partition coefficient calculated by readily available softwares like clogP and ACD/logP, and the commonly known melting point of the solute. Recently, Bahadori et al. proposed that their genetic algorithm support vector machine is a "better" predictor. This paper compares the use of the of Bahadori et al. model for the prediction of aqueous solubility to the existing GSE model.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Alantary D,Yalkowsky Sdoi
10.1080/10837450.2017.1321663subject
Has Abstractpub_date
2018-09-01 00:00:00pages
739-740issue
7eissn
1083-7450issn
1097-9867journal_volume
23pub_type
杂志文章abstract::Orally dissolving tablets (ODTs) represent one of the recent advances in drug delivery. The foremost objective of this study was to optimize the utilization of lubricant sodium stearyl fumarate in the preparation of dextromethorphan hydrobromide ODTs with enhanced taste-masking properties. The simple blending of sodiu...
journal_title:Pharmaceutical development and technology
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doi:10.1080/10837450.2019.1579228
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journal_title:Pharmaceutical development and technology
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doi:10.1080/10837450.2017.1287728
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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更新日期:2015-05-01 00:00:00
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journal_title:Pharmaceutical development and technology
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doi:10.3109/10837450.2010.522585
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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更新日期:2020-01-01 00:00:00
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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doi:10.1080/10837450.2017.1321662
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journal_title:Pharmaceutical development and technology
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更新日期:2021-01-04 00:00:00
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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更新日期:2015-01-01 00:00:00
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
pub_type: 杂志文章,评审
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journal_title:Pharmaceutical development and technology
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更新日期:2019-01-01 00:00:00
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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pub_type: 杂志文章
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