Abstract:
:In this study, the degradation of Octastatin, a cyclic octapeptide analog of somatostatin, was examined as a function of pH, temperature, buffer, and ionic strength by reversed-phase gradient high-performance liquid chromatography. Degradation of Octastatin followed a first-order kinetics. Various buffer species such as acetate, ammonium acetate, citrate, glutamate, phosphate, and borate showed differing effects on the degradation of the octapeptide. Good stability was found in glutamate and acetate buffer of pH 4.0. Degradation of Octastatin was greater in citrate- or phosphate-containing buffers than in glutamate or acetate buffers. With phosphate buffer, higher buffer concentration caused greater degradation, while in acetate buffer, the effect of buffer concentration and ionic strength was negligible. In addition, the degradation of Octastatin was markedly inhibited by increasing the concentration of glutamate buffer. This study allows the prediction of good stability in acetate buffer (0.01 M, pH 4.0) with a t90% of 84.1 days at 20 degrees C.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Jang SW,Woo BH,Lee JT,Moon SC,Lee KC,DeLuca PPdoi
10.3109/10837459709022640subject
Has Abstractpub_date
1997-11-01 00:00:00pages
409-14issue
4eissn
1083-7450issn
1097-9867journal_volume
2pub_type
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journal_title:Pharmaceutical development and technology
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journal_title:Pharmaceutical development and technology
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