Abstract:
:The unstirred aqueous boundary layer (ABL) thickness was determined for modified Franz diffusion cells using three test compounds--parathion, 4-hexylresorcinol, and 2,4-dinitrochlorobenzene (DNCB). Steady-state fluxes through one, two, and three dialysis membranes in series were achieved in donor-saturated, infinite-dose permeation experiments. These results were then used to calculate the total diffusive resistance for each case, as well as an extrapolated zero membrane value which was used in conjunction with an estimate of the aqueous diffusivities to calculate the ABL thickness. The resulting value (mean ± SE) was 0.070 ± 0.004 cm.
journal_name
Pharm Dev Technoljournal_title
Pharmaceutical development and technologyauthors
Miller MA,Kasting Gdoi
10.3109/10837450.2011.572895subject
Has Abstractpub_date
2012-11-01 00:00:00pages
705-11issue
6eissn
1083-7450issn
1097-9867journal_volume
17pub_type
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