Controlled release of DSBP from genipin-crosslinked gelatin thin films.

Abstract:

:Controlled release of a marker drug, 4,4'-bis(2-sulfostyryl) biphenyl (DSBP) from genipin crosslinked gelatin thin films, with application to drug delivery by transdermal patches is studied in this paper. A simple method for fabrication of nano-thin films, using basic lab equipment is introduced. This method consists of two steps: dipping of the substrate in a deposition solution, followed by centrifugation of the substrate. Also, swelling and drug release from thin films is modeled, using the Fick's second law of diffusion. The effect of genipin concentration on release of DSBP molecules from thin films is investigated, experimentally and numerically. The results show that controlled release of DSBP from the genipin-crosslinked gelatin thin films is achieved, using various concentrations of genipin in gelatin.

journal_name

Pharm Dev Technol

authors

Abbasi A,Eslamian M,Heyd D,Rousseau D

doi

10.1080/10837450802309679

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

549-57

issue

6

eissn

1083-7450

issn

1097-9867

pii

901742539

journal_volume

13

pub_type

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