Odor coding in the mammalian olfactory epithelium.

Abstract:

:Noses are extremely sophisticated chemical detectors allowing animals to use scents to interpret and navigate their environments. Odor detection starts with the activation of odorant receptors (ORs), expressed in mature olfactory sensory neurons (OSNs) populating the olfactory mucosa. Different odorants, or different concentrations of the same odorant, activate unique ensembles of ORs. This mechanism of combinatorial receptor coding provided a possible explanation as to why different odorants are perceived as having distinct odors. Aided by new technologies, several recent studies have found that antagonist interactions also play an important role in the formation of the combinatorial receptor code. These findings mark the start of a new era in the study of odorant-receptor interactions and add a new level of complexity to odor coding in mammals.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Kurian SM,Naressi RG,Manoel D,Barwich AS,Malnic B,Saraiva LR

doi

10.1007/s00441-020-03327-1

subject

Has Abstract

pub_date

2021-01-06 00:00:00

eissn

0302-766X

issn

1432-0878

pii

10.1007/s00441-020-03327-1

pub_type

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