Development of the granule population in heterophil granulocytes from rat bone marrow.

Abstract:

:The development of the heterophil granulocyte in the bone marrow of the rat is described, and an electron-microscopical analysis of the changes in the cytoplasm as well as in the granule population in several stages of maturation is reported. Three types of granule originate in consecutive stages of heterophil maturation. Granules with an internal fine structure (nucleated granules) are the first to be formed, i.e., in early promyelocytes; azurophil granules are formed in late promyelocytes; and specific granules appear in myelocytes. Quantitative analysis showed that the granule population in mature cells, i.e., about 160 granules per electron micrograph, is composed of roughly 14% nucleated granules, 10% azurophil granules, and 76% specific granules. Three cell stages were observed in mitosis: the early promyelocyte, the late promyelocyte, and the myelocyte. Granule counts in non-dividing cells confirmed the occurrence of mitosis in the late promyelocyte and myelocyte.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Brederoo P,van der Meulen J

doi

10.1007/BF00211466

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

433-49

issue

3

eissn

0302-766X

issn

1432-0878

journal_volume

228

pub_type

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