Evidence for corticotropin releasing factor (CRF) synthesis in the preoptic nucleus of Xenopus laevis tadpoles: a preliminary report based on lesion experiments.

Abstract:

:For the study of the hypothalamo-hypophysial system of Xenopus laevis tadpoles, hypothalamic lesions were made by means of the electrocoagulation technique. Lesioning of the ventral region of the preoptic nucleus resulted in a decrease of the number of ACTH cells in the pars distalis of the pituitary gland and in a diminution of the PAS-positive reaction of these cells. In addition, regeneration of the neurosecretory cells of the ventral region of the preoptic nucleus observed 6 weeks after lesioning was accompanied by the reappearance of normal PAS-positive ACTH cells in the pars distalis. It is suggested that the neurosecretory cells of the ventral region of the preoptic nucleus of Xenopus laevis tadpoles are related to the ACTH synthesizing cells, probably by producing CRF.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Notenboom CD,Terlou M,Maten ML

doi

10.1007/BF00219304

keywords:

subject

Has Abstract

pub_date

1976-06-11 00:00:00

pages

23-31

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

169

pub_type

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