Intraepithelial inclusions resembling human biondi bodies in the choroid plexus of an aged chimpanzee.

Abstract:

:Complex intracellular inclusion bodies of the Biondi type were observed in the choroidal epithelium (choroid plexus of the lateral ventricle) of a 43-year-old male chimpanzee. The specific components of these inclusions are bundles of filaments 8-15 nm in diameter, which are associated with lipid droplets and a wide variety of unidentified inclusions of differing electron density. Biondi bodies are characteristic inclusions of the choroid plexus of aged humans but have been claimed to be absent from the choroidal epithelium of senescent animals including nonhuman primates. The present finding of Biondi body-like inclusions in an aged chimpanzee underscores the usefulness of nonhuman primates as models for studies of aging, seeking to gain a better understanding of gerontological aspects of the human brain.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Oksche A,Liesner R,Tigges J,Tigges M

doi

10.1007/BF00217876

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

467-9

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

235

pub_type

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