Electron-microscopic immunohistochemical study of the localization of immunoglobulin G in the choroid plexus of the rat.

Abstract:

:The localization of autologous antiperoxidase immunoglobulin G (IgG) was studied in the choroid plexus of Lewis rats immunized against horseradish peroxidase (HRP). This experiment was performed to study the permeability of the choroid plexus to intravascular IgG. It was shown that autologous IgG was present in the extravascular spaces. The transendothelial transfer appeared to occur mainly via the fenestrations and some interendothelial junctions. No transfer of IgG at the level of epithelial cells toward the cerebrospinal fluid was demonstrated. Interstitial spaces in contact with the connective-tissue cells of the choroid stroma were strongly labeled. The significance of these spaces remains hypothetical and raises the question of the fate of IgG from the interstitial space.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Fleury J,Bellon B,Bernaudin JF,Bouchaud C,Pinchon MC,Kuhn J,Poirier J

doi

10.1007/BF00215159

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

177-82

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

238

pub_type

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