Induction by progesterone of a sexual dimorphism of estrogen uptake by anterior pituitary cells in situ.

Abstract:

:The effects of progesterone pretreatment on in vivo 3H-estrogen uptake by five anterior pituitary cell types was analyzed by means of a quantitative autoradiographic-immunocytochemical technique. Male and female rats castrated for 14 days show nuclear concentration of label in all five cell types one h after injection of 3H-estradiol, whether progesterone treated or not. The order of labeling intensity is gonadotropes greater than or equal to lactotropes = somatotropes greater than thyrotropes = corticotropes. Progesterone treatment induces a dramatic sexual dimorphism in estrogen uptake; it significantly increases 3H-estrogen uptake in all female cell types. In males, progesterone decreases uptake in gonadotropes while not altering uptake in other cell types.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Keefer DA

doi

10.1007/BF00236250

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

75-86

issue

1

eissn

0302-766X

issn

1432-0878

journal_volume

215

pub_type

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