Cellular localization of cystic fibrosis transmembrane regulator protein in piglet and mouse intestine.

Abstract:

:Antibodies raised against the cystic fibrosis transmembrane regulator protein (CFTR) were used to localize CFTR in intestinal tissues of piglets and mice. Positive staining for CFTR was detected in goblet cells of both species. A second population of epithelial cells of unknown phenotype was also labeled by anti-CFTR antibodies. The labeling pattern was abolished by preincubation of anti-CFTR antibodies with the immunogen or when non-immune IgG was used in place of anti-CFTR antibodies. These results support other studies that suggest that alterations in goblet cell function may be involved in the intestinal abnormalities associated with cystic fibrosis.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Hayden UL,Carey HV

doi

10.1007/s004410050531

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

209-13

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

283

pub_type

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