Retrograde labeling of regenerated electromotor neurons with HRP in a teleost fish, Sternarchus albifrons: relation to cell death.

Abstract:

:Back-labeling of regenerated electromotor neurons in the teleost Sternarchus albifrons was performed to test the hypothesis that, in regenerated spinal cord, incorrectly located electromotor neurons are eliminated because their axons do not reach the correct target area (electric organ). In each cross section examined, all of the regenerated electromotor neurons ipsilateral to the implantation site were labeled with horseradish peroxidase, including those ectopic cells located at the edge of the cord, which are later eliminated by selective cell death. Retrograde labeling of these ectopic neurons demonstrates that their axons do extend into the correct target area (the regenerated electric organ). Thus total misdirection of the axons cannot be the cause of their subsequent cell death. We conclude that selective neuronal death in this system does not reflect the absence of axonal projection to the correct target area.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Anderson MJ,Fong HL,Waxman SG

doi

10.1007/BF00217166

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

237-40

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

241

pub_type

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