Abstract：
:Mast cells (MCs) and airway nerves play an important role in allergic asthma. However, little is known about the MCs and their interaction with airway nerves during allergic airway inflammation. This study aims to investigate the distribution and proliferation of MC populations in different lung compartments, along with the association of mast cells with nerve endings, using a house dust mite (HDM) model for allergic airway inflammation. BALB/c mice were exposed to HDM extract intranasally (25 μg/50 μl) for 5 consecutive days a week over 7 weeks. Immunofluorescence and Edu stains were used to examine the colocalisation of MCs and nerves and the proliferation of MCs, respectively. HDM treatment caused an increased migration of MCs into bronchi, alveolar parenchyma and airway vessels. The proportions of tryptase-chymase expressing MC (MCTC) increased significantly in the bronchi and the alveolar parenchyma but not in the vascular tissues, by allergic airway inflammation. The association of MCs with nerves was found only in the bronchi and there were no changes in comparison of controls to HDM-treated animals. The present study shows a strong migration of tryptase expressing MC (MCT) and MCTC into the bronchi and the alveolar parenchyma, as well as of MCT in the vascular compartment under HDM treatment. This supports the hypothesis that these mast cell populations may contribute to allergic airway inflammation.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Schmit D,Le DD,Heck S,Bischoff M,Tschernig T,Herr C,Beisswenger C,Kobelt P,Lepper PM,Chung KF,Bals R,Dinh QTdoi
10.1007/s00441-017-2597-9subject
Has Abstractpub_date
2017-08-01 00:00:00pages
331-340issue
2eissn
0302-766Xissn
1432-0878pii
10.1007/s00441-017-2597-9journal_volume
369pub_type
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