Abstract:
:Osteoblasts are specialized mesenchyme-derived cells accountable for bone synthesis, remodelling and healing. Differentiation of osteoblasts from mesenchymal stem cells (MSC) towards osteocytes is a multi-step process strictly controlled by various genes, transcription factors and signalling proteins. The aim of this review is to provide an update on the nature of bone-forming osteoblastic cells, highlighting recent data on MSC-osteoblast-osteocyte transformation from a molecular perspective and to discuss osteoblast malfunctions in various bone diseases. We present here the consecutive stages occurring in the differentiation of osteoblasts from MSC, the transcription factors involved and the role of miRNAs in the process. Recent data concerning the pathogenic mechanisms underlying the loss of bone mass and architecture caused by malfunctions in the synthetic activity and metabolism of osteoblasts in osteoporosis, osteogenesis imperfecta, osteoarthritis and rheumatoid arthritis are discussed. The newly acquired knowledge of the ontogeny of osteoblasts will assist in unravelling the abnormalities taking place during their differentiation and will facilitate the prevention and/or treatment of bone diseases by therapy directed against altered molecules and mechanisms.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Titorencu I,Pruna V,Jinga VV,Simionescu Mdoi
10.1007/s00441-013-1750-3subject
Has Abstractpub_date
2014-01-01 00:00:00pages
23-33issue
1eissn
0302-766Xissn
1432-0878journal_volume
355pub_type
杂志文章,评审abstract::A technique has been developed to obtain viable, isolated and enriched populations of gastrin cells (G-cells) from the rat stomach. Restricted tissue samples from a small area of the pyloric antrum known to be particularly rich in G-cells, were sequentially digested with pronase followed by mechanical agitation, to re...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00236409
更新日期:1979-08-01 00:00:00
abstract::The spermatogonial stem cell line in prepubertal and adult bovine testis was studied by electron microscopy and protein gene product 9.5 immunohistochemistry. Three successive spermatogonia precursor cell configurations were observed. Small basal stem cells were found to possess a spherical shape and nuclei with two t...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00583394
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abstract::The application of autologous dermal fibroblasts has been shown to improve burn wound healing. However, a major hurdle is the availability of sufficient healthy skin as a cell source. We investigated fetal dermal cells as an alternative source for cell-based therapy for skin regeneration. Human (hFF), porcine fetal (p...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-015-2293-6
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abstract::Glaucoma, a disease of the optic nerve and retina, causes blindness in millions of people worldwide. Currently available therapies for this disease only attempt to reduce intraocular pressure, the major risk factor, without addressing the associated optic neuropathy and retinopathy. Development of glaucoma neuroprotec...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-013-1584-z
更新日期:2013-08-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-017-2726-5
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abstract::In the ovoviviparous fly, Sarcophaga bullata, vitellogenesis in cyclic; a process reflected in ultrastructural changes in the fat body cells and oenocytes. At eclosion the larval fat body has not yet completely disappeared. During vitellogenesis the fat body cells are specialized for intensive protein synthesis showin...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216728
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abstract::Renovascular hypertension (RVH) is a progressive disease, leading to chronic kidney disease when untreated and no specific treatment is available. Therefore, development of new therapeutic modalities is imperative. RVH is triggered by renal artery stenosis and subsequent renin-angiotensin-aldosterone system activation...
journal_title:Cell and tissue research
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218095
更新日期:1986-01-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0308-z
更新日期:2007-03-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218169
更新日期:1978-07-05 00:00:00
abstract::The distribution and interconnections of brainstem catecholamine cell groups thought to be important in cardiovascular control were studied using histochemical and ultrastructural techniques in the rabbit. Lesions and microinjections of horseradish peroxidase (HRP) were made in the nucleus tractus solitarii in the dor...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00209963
更新日期:1981-01-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章,评审
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更新日期:1998-06-01 00:00:00
abstract::Mice and rats emit and perceive calls in the ultrasonic range, i.e., above the human hearing threshold of about 20 kHz: so-called ultrasonic vocalizations (USV). Juvenile and adult rats emit 22-kHz USV in aversive situations, such as predator exposure and fighting or during drug withdrawal, whereas 50-kHz USV occur in...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00234394
更新日期:1980-01-01 00:00:00
abstract::Chronic tinnitus (ringing of the ears) is a medically untreatable condition that reduces quality of life for millions of individuals worldwide. Most cases are associated with hearing loss that may be detected by the audiogram or by more sensitive measures. Converging evidence from animal models and studies of human ti...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-014-1992-8
更新日期:2015-07-01 00:00:00
abstract::An ultrastructural study of the rostral pars distalis of the pituitary of Aphanius dispar specimens taken from freshwater or hypersaline marshes revealed significant structural differences which indicate higher activity of the prolactin cells in the hypotonic medium. Prolactin cells from freshwater specimens had large...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221103
更新日期:1977-04-20 00:00:00
abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP) and helospectin are two vasoactive intestinal polypeptide (VIP)-related neuropeptides that have recently been demonstrated in the mammalian gut; the aim of this study was to reveal their occurrence and localisation in the gastrointestinal tract, swimbladder, u...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00300227
更新日期:1994-09-01 00:00:00
abstract::For the study of the hypothalamo-hypophysial system of Xenopus laevis tadpoles, hypothalamic lesions were made by means of the electrocoagulation technique. Lesioning of the ventral region of the preoptic nucleus resulted in a decrease of the number of ACTH cells in the pars distalis of the pituitary gland and in a di...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00219304
更新日期:1976-06-11 00:00:00
abstract::The fine structure of the pore cells in pre- and post-hatched Deroceras reticulatum is described. The cells have been divided into three main types on morphological grounds, one type being particulary rich in glycogen. Certain pore cells contain haemocyanin granules in grooves below cytoplasmic tongues, and in charact...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00234637
更新日期:1979-12-01 00:00:00
abstract::Although the function and effects of many growth factors and extracellular matrix (ECM) molecules have been described for several periodontal tissues in vivo and in vitro, the molecular interactions involved in the communication between cells of the periodontal ligament and the alveolar bone are poorly understood. To ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-004-1026-z
更新日期:2005-03-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00217865
更新日期:1984-01-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-014-1799-7
更新日期:2014-05-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221652
更新日期:1989-07-01 00:00:00
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journal_title:Cell and tissue research
pub_type: 杂志文章
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abstract::The location of the perikarya of LH-RH neurons in the rat hypothalamus and their pathways to the median eminence were studied by immunohistochemistry and radioimmunoassay after placing stereotaxic electrolytic lesions in several parts of the hypothalamus. The principal location of the cell somata was found to be in th...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00234184
更新日期:1979-05-25 00:00:00
abstract::Two dozen hybrid clones were produced by fusion of diploid embryonic stem (ES) cells positive for green fluorescent protein (GFP) with tetraploid fibroblasts derived from DD/c and C57BL-I(I)1RK mice. Cytogenetic analysis demonstrated that most cells from these hybrid clones contained near-hexaploid chromosome sets. Ad...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-010-0987-3
更新日期:2010-06-01 00:00:00
abstract::Considerable evidence indicates that the state of ocular connective tissues and their response in glaucomatous disease affect the degree of glaucoma damage. Both experimental and clinical data suggest that improved diagnostic and prognostic information can be derived from the assessment of the mechanical responsivenes...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
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更新日期:2013-08-01 00:00:00
abstract::Spermatozoa from the cauda epididymidis of gossypol-treated rats exhibit distinctive departures from the morphology of spermatozoa from control rats: wrinkled and disorganized cell membrane in the head and tail regions, cell membrane missing from segments of the tail midpiece and principal piece regions, malformed hea...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00210003
更新日期:1981-01-01 00:00:00
abstract::The midgut cells of Tomocerus minor (Insecta, Collembola) were examined with the electron microscope and cytochemically. The midgut epithelium consists of a series of cells characterised by numerous mineral concretions scattered throughout the cytoplasm. Mitochondria are abundant; microvilli are well developed at the ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00236347
更新日期:1979-01-30 00:00:00
abstract::The true surface of rabbit spinal ganglion neurons has been made directly accessible to scanning electron-microscope observation after removal of both the connective tissue and satellite cells that normally cover it. The neuronal surface is characterized by a profusion of slender projections whose shapes have been det...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00297502
更新日期:1990-04-01 00:00:00