Abstract:
:SEPTIN9 (SEPT9) is a filament-forming protein involved in numerous cellular processes. We have used a conditional knock out allele of Sept9 to specifically delete Sept9 in T-cells. As shown by fluorescence-activated cell sorting, loss of Sept9 at an early thymocyte stage in the thymus results in increased numbers of double-negative cells indicating that SEPT9 is involved in the transition from the double-negative stage during T-cell development. Accordingly, the relative numbers of mature T-cells in the periphery are decreased in mice with a T-cell-specific deletion of Sept9. Proliferation of Sept9-deleted CD8(+) T-cells from the spleen is decreased upon stimulation in culture. The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8(+) central memory T-cells.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Lassen LB,Füchtbauer A,Schmitz A,Sørensen AB,Pedersen FS,Füchtbauer EMdoi
10.1007/s00441-013-1618-6subject
Has Abstractpub_date
2013-06-01 00:00:00pages
695-705issue
3eissn
0302-766Xissn
1432-0878journal_volume
352pub_type
杂志文章abstract::The responses of non-neuronal cells to the degeneration of neuroblasts were studied in the spinal ganglia of the chick embryo. Reactive changes of the non-neuronal cells were not apparent during the early stage of degeneration of the neuroblast, but during the later stages of degeneration evidence was found suggesting...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00210032
更新日期:1978-06-26 00:00:00
abstract::The neurotensin-cell is identified immunohistochemically and ultrastructurally by differential counting of endocrine cells in the gut of a primate (Tupaia belangeri). Utilizing light microscopy, the EC-cells are identified by the Masson-Fontana silver stain; with the same method the neurotensin cells are not stained. ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220968
更新日期:1977-11-23 00:00:00
abstract::The effects, on the maternal mammary gland, of diets containing similar lipid percentages but differing in composition of polyunsaturated fatty acids (PUFA) have been assessed in rats during pregnancy and lactation. For this purpose, tuna fish oil (an n-3-PUFA-enriched oil) and corn oil (an n-6-PUFA-enriched oil) were...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-012-1523-4
更新日期:2013-03-01 00:00:00
abstract::The spleen of the oriental fire-bellied toad, Bombina orientalis, consists of well-developed white pulp, separated from the lymphocytic marginal zone by the connective tissue boundary layer. Injection of peroxidase-conjugated rabbit anti-peroxidase revealed that these immune complexes were localized on the surface of ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00297553
更新日期:1993-01-01 00:00:00
abstract::The notion that teeth contain stem cells is based on the well-known repairing ability of dentin after injury. Dental stem cells have been isolated according to their anatomical locations, colony-forming ability, expression of stem cell markers, and regeneration of pulp/dentin structures in vivo. These dental-derived s...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-007-0467-6
更新日期:2008-01-01 00:00:00
abstract::Transplantation of ligament-tissue-derived stem cells has become a promising approach in the repair of injured ligament. Neovascularization plays an important role in ligament healing and remodeling. Recently, human umbilical-cord-blood-derived CD34+ cells have been reported to contribute to neoangiogenesis. Therefore...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-015-2250-4
更新日期:2015-12-01 00:00:00
abstract::Digital dermatitis (DD), a common ulcerative disease of the bovine foot causing lameness and reducing productivity and animal welfare, is associated with infection by spirochete Treponema bacteria. Topical tetracycline, the most common treatment, has inconsistent cure rates; therefore, new therapeutic options are need...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-019-03082-y
更新日期:2020-02-01 00:00:00
abstract::The papillary muscle of the cat heart's right ventricle has not been studied previously with quantitative ultrastructural techniques despite its wide use for functional studies. This tissue was perfusion-fixed, processed for electron microscopy, and morphometric techniques were used to assess the ultrastructural chara...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216200
更新日期:1983-01-01 00:00:00
abstract::In the ovoviviparous fly, Sarcophaga bullata, vitellogenesis in cyclic; a process reflected in ultrastructural changes in the fat body cells and oenocytes. At eclosion the larval fat body has not yet completely disappeared. During vitellogenesis the fat body cells are specialized for intensive protein synthesis showin...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216728
更新日期:1981-01-01 00:00:00
abstract::Tanycytes in the median eminence (ME) of the rat exhibit morphological features suggesting their possible participation in transport phenomena. After adrenalectomy, which modifies the hypothalamo-hypophyseal axis, they undergo morphological changes characterized by an accumulation of lipid droplets, an increased numbe...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00215708
更新日期:1982-01-01 00:00:00
abstract::Employing electron-microscopic methods that help retain polyanionic materials, we describe the extracellular coverings of a sea urchin (Lytechinus variegatus) throughout ontogeny. The surface of the embryo is covered by a two-layered cuticle (commonly called the hyaline layer), which in turn is covered by a granular l...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218028
更新日期:1985-01-01 00:00:00
abstract::In the present study, we have analyzed the direct effects of cytokines, which mediate the acute-phase response in liver, on connexin expression and gap-junctional intercellular communication in immortalized MHSV12 mouse hepatocytes. When these cells were stimulated for 24 h with interleukin 1 and interleukin 6, the am...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410051184
更新日期:1998-11-01 00:00:00
abstract::The stem cells with their distinct ability of self-renewal and differentiation are considered an innovation in wound healing. However, there is lack of studies comparing the differential effect of the type and administration route of stem cells in the wound healing context. Thus, the current study has been designed to...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-018-2879-x
更新日期:2018-11-01 00:00:00
abstract::Whole pigs lenses were fixed, critical-point dried and fractured, and the internal surfaces examined with a scanning electron microscope. At various locations from the equator to the center of the lens four types of fibers can be distinguished. The superficial fibers have small interdigitations. Cortical lens fibers, ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00217281
更新日期:1982-01-01 00:00:00
abstract::The smooth muscle of rabbit portal vein was studied by electron microscopy with particular emphasis on the mechanical linkage between the muscle cells and on the distribution of connective tissue. The media of this vein is composed of inner circular and outer longitudinal muscle layers which are orientated almost perp...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00237614
更新日期:1980-01-01 00:00:00
abstract::An ultrastructural study of the rostral pars distalis of the pituitary of Aphanius dispar specimens taken from freshwater or hypersaline marshes revealed significant structural differences which indicate higher activity of the prolactin cells in the hypotonic medium. Prolactin cells from freshwater specimens had large...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00221103
更新日期:1977-04-20 00:00:00
abstract::This study provides information on the rates of DNA synthesis, sites of DNA synthesis, and DNA content of the avian salt gland during the osmotic stressing (plasma membrane synthesis) and destressing (plasma membrane turnover) cycle, in an effort to better understand the relationship of cell turnover to the initial ev...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214782
更新日期:1982-01-01 00:00:00
abstract::A freeze-etch replica method combined with biochemical analyses was used to investigate the ultrastructural organization of the bovine Descemet's membrane. The freeze-etch replica observations revealed that the intact Descemet's membranes were composed of stacks of two-dimensionally arranged hexagonal lattices, in whi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00218356
更新日期:1982-01-01 00:00:00
abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP) and helospectin are two vasoactive intestinal polypeptide (VIP)-related neuropeptides that have recently been demonstrated in the mammalian gut; the aim of this study was to reveal their occurrence and localisation in the gastrointestinal tract, swimbladder, u...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00300227
更新日期:1994-09-01 00:00:00
abstract::The immunocytochemical localization of bovine oviduct-specific glycoproteins was investigated by light and electron microscopy. Using monoclonal antibodies (MAbs) specific for bovine oviductal glycoproteins, 3 regions (fimbriae, ampulla, and isthmus) of the epithelium in the bovine oviduct we studied during the follic...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00327983
更新日期:1993-10-01 00:00:00
abstract::Antibodies raised against the cystic fibrosis transmembrane regulator protein (CFTR) were used to localize CFTR in intestinal tissues of piglets and mice. Positive staining for CFTR was detected in goblet cells of both species. A second population of epithelial cells of unknown phenotype was also labeled by anti-CFTR ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050531
更新日期:1996-02-01 00:00:00
abstract::The fan-shaped body is the largest substructure of the central complex in Drosophila melanogaster. Two groups of large-field neurons that innervate the fan-shaped body, viz., F1 and F5 neurons, have recently been found to be involved in visual pattern memory for "contour orientation" and "elevation" in a rut-dependent...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-009-0781-2
更新日期:2009-06-01 00:00:00
abstract::In plants, intercellular structures named plasmodesmata (PD) form a continuous cytoplasmic network between neighboring cells. PD pores provide channels for intercellular symplasmic (cell-to-cell) transport throughout most tissues of the plant body. Cell-defining proteins, such as transcription factors, and regulatory ...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-012-1550-1
更新日期:2013-04-01 00:00:00
abstract::The glandular lobe of the corpus cardiacum (CC) of Locusta migratoria contains secretory cells and axon terminals. It is generally accepted that the glandular cells produce an adipokinetic hormone which stimulates the release of diglycerides from the fat body. The axon terminals are supposed to be involved in the regu...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00223069
更新日期:1977-10-26 00:00:00
abstract::In vitro incubation of autonomic nerves with vinblastine sulphate (1 times 10(-4) M) caused a disappearance of microtubules within 15 min; during the following 15 min paracrystalline arrays appeared within the axons. An increase in the abundance of microfilaments was also observed, but these did not appear to arise fr...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00220136
更新日期:1976-02-25 00:00:00
abstract::Homeobox genes encode transcription factors that regulate embryonic development programs including organogenesis, axis formation and limb development. Previously, we identified and cloned a mouse double homeobox gene, Duxbl, whose homeodomain exhibits the highest identity (67 %) to human DUX4, a candidate gene of faci...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-014-1974-x
更新日期:2014-11-01 00:00:00
abstract::Calbindin is a calcium-binding protein, commonly found in certain subpopulations of the enteric nervous system in mammals. Recently, calbindin-immunoreactive enteric neurons have also been demonstrated in shorthorn sculpin (Myoxocephalus scorpius). In the present study, calbindin immunoreactivity has been investigated...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-011-1135-4
更新日期:2011-04-01 00:00:00
abstract::The burrower bug Scaptocoris castanea is an important soybean and pasture pest in Brazil, with an underground habit feeding directly on the sap of the roots. Underground habit hinders control and knowledge of the biology and physiology of this pest. This study describes the anatomy, histology, ultrastructure and symbi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-020-03197-7
更新日期:2020-11-01 00:00:00
abstract::The distribution of immunoreactive thyrotropin-releasing hormone (TRH) in the forebrain and hypophysis of Rana catesbeiana was studied by means of specific radioimmunoassay and immunohistochemistry based on peroxidase-antiperoxidase (PAP) techniques. A relatively high concentration of immunoassayable TRH is present in...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00212220
更新日期:1983-01-01 00:00:00
abstract::Nucleoside di-phosphate kinase enzyme (NDPK) isoforms, encoded by the nm23 family of genes, may be involved in various cellular differentiation and proliferation processes. We have therefore analyzed the expression of nm23-M1, -M2, -M3, and -M4 during embryonic mouse development. In situ hybridization data has reveale...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-005-0036-9
更新日期:2005-12-01 00:00:00