Septin9 is involved in T-cell development and CD8+ T-cell homeostasis.

Abstract:

:SEPTIN9 (SEPT9) is a filament-forming protein involved in numerous cellular processes. We have used a conditional knock out allele of Sept9 to specifically delete Sept9 in T-cells. As shown by fluorescence-activated cell sorting, loss of Sept9 at an early thymocyte stage in the thymus results in increased numbers of double-negative cells indicating that SEPT9 is involved in the transition from the double-negative stage during T-cell development. Accordingly, the relative numbers of mature T-cells in the periphery are decreased in mice with a T-cell-specific deletion of Sept9. Proliferation of Sept9-deleted CD8(+) T-cells from the spleen is decreased upon stimulation in culture. The altered T-cell homeostasis caused by the loss of Sept9 results in an increase of CD8(+) central memory T-cells.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Lassen LB,Füchtbauer A,Schmitz A,Sørensen AB,Pedersen FS,Füchtbauer EM

doi

10.1007/s00441-013-1618-6

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

695-705

issue

3

eissn

0302-766X

issn

1432-0878

journal_volume

352

pub_type

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